Evaluation of Herbal–Drug Interaction Data in Tertiary Resources

Use of complementary and alternative medicines (CAM) for preventive and therapeutic purposes has increased tremendously in the last two decades internationally. The manufacturers of these products are not required to submit proof of safety or efficacy to the Food and Drug Administration. As a result, the adverse effects and drug interactions associated with them are largely unknown. In this chapter, the author presents interactions of herbal medicines with other medicines (herbal or non-herbal). A large number of herbal drugs, including from single drug to a variety of mixtures have been used to treat kidney disorders. Herb-herb or herb drug interaction has been reported intensively during last decade, therefore it becomes important to keep an eye on the use of combination herbal therapy in order to avoid serious results because of interactions with each other. Due to the growing awareness about the interactions and side effects of herbal drugs/supplements over the past few years, regulatory bodies are working on these issues and pharmacopoeias are being developed for reference.

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Herbal drug interaction: Mechanistic details through the pharmacokinetic portfolio

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527319666201008151710 ◽

2020 ◽

Vol 19 ◽

Author(s):

Salman Ahmed ◽

Haroon Khan ◽

Hamed Mirzaei ◽

Muhammad Mohtasheemul Hasan ◽

Mohamed Eddouks ◽

...

Keyword(s):

Drug Interaction ◽

Herbal Product ◽

Herbal Drug ◽

Active Constituent ◽

Herbal Products ◽

Product Regulation ◽

The Subject ◽

Potential Interactions ◽

Number Of Individuals ◽

Pharmacokinetic Drug

Background: A huge number of individuals today use herbs as drug alongside medicine and non-physician recommended medications, thought about natural and safe, huge numbers of these herbs can potentially interact with other drugs, causing hazardous adverse effects and /or diminished advantages of prescription. Objective: It ought to be comprehended that herbal drugs contain multiple active compounds in different percentages which can change the enzymatic frameworks, transporters and additionally the physiologic processes. Methods: Different search engines such as Googlescholar, Scopus, ScienceDirect, were used for the search of the data on the subject; pharmacokinetic drug interactions with the herbal products. Results: This worldwide increment in herbal drug popularity has risen with respect to HDIs. These interactions PD or PK are particularly significant for medications. Assessment of herbal drug interaction is difficult because of inconsistency in herbal drug composition, and frequently meager information of active constituent pharmacokinetic. These restrictions are bewildered further by the differing points of view concerning herbal product regulation. Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices in regard to patient safety. The expanding comprehension of HDPKI will make more attention to the potential interactions.

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Herbal Drug Interactions

10.4018/978-1-6684-3546-5.ch008 ◽

2022 ◽

pp. 120-141

Author(s):

Mymoona Akhter

Keyword(s):

Drug Interaction ◽

Side Effects ◽

Adverse Effects ◽

Drug Interactions ◽

Herbal Medicines ◽

Herbal Drugs ◽

Herbal Drug ◽

Herbal Therapy ◽

Alternative Medicines ◽

Regulatory Bodies

Use of complementary and alternative medicines (CAM) for preventive and therapeutic purposes has increased tremendously in the last two decades internationally. The manufacturers of these products are not required to submit proof of safety or efficacy to the Food and Drug Administration. As a result, the adverse effects and drug interactions associated with them are largely unknown. In this chapter, the author presents interactions of herbal medicines with other medicines (herbal or non-herbal). A large number of herbal drugs, including from single drug to a variety of mixtures have been used to treat kidney disorders. Herb-herb or herb drug interaction has been reported intensively during last decade, therefore it becomes important to keep an eye on the use of combination herbal therapy in order to avoid serious results because of interactions with each other. Due to the growing awareness about the interactions and side effects of herbal drugs/supplements over the past few years, regulatory bodies are working on these issues and pharmacopoeias are being developed for reference.

Download Full-text