Herbal drug interaction: Mechanistic details through the pharmacokinetic portfolio

2020 ◽  
Vol 19 ◽  
Author(s):  
Salman Ahmed ◽  
Haroon Khan ◽  
Hamed Mirzaei ◽  
Muhammad Mohtasheemul Hasan ◽  
Mohamed Eddouks ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Herbal Product ◽  
Herbal Drug ◽  
Active Constituent ◽  
Herbal Products ◽  
Product Regulation ◽  
The Subject ◽  
Potential Interactions ◽  
Number Of Individuals ◽  
Pharmacokinetic Drug

Background: A huge number of individuals today use herbs as drug alongside medicine and non-physician recommended medications, thought about natural and safe, huge numbers of these herbs can potentially interact with other drugs, causing hazardous adverse effects and /or diminished advantages of prescription. Objective: It ought to be comprehended that herbal drugs contain multiple active compounds in different percentages which can change the enzymatic frameworks, transporters and additionally the physiologic processes. Methods: Different search engines such as Googlescholar, Scopus, ScienceDirect, were used for the search of the data on the subject; pharmacokinetic drug interactions with the herbal products. Results: This worldwide increment in herbal drug popularity has risen with respect to HDIs. These interactions PD or PK are particularly significant for medications. Assessment of herbal drug interaction is difficult because of inconsistency in herbal drug composition, and frequently meager information of active constituent pharmacokinetic. These restrictions are bewildered further by the differing points of view concerning herbal product regulation. Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices in regard to patient safety. The expanding comprehension of HDPKI will make more attention to the potential interactions.

Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China

2020 ◽  
Vol 21 ◽  
Author(s):  
Xuan Yu ◽  
Zixuan Chu ◽  
Jian Li ◽  
Rongrong He ◽  
Yaya Wang ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Interactions ◽  
Penicillin G ◽  
Literature Mining ◽  
Human Pharmacokinetics ◽  
P450 Enzyme ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug ◽  
Sepsis Care

Background: Many antibiotics have a high potential for having an interaction with drugs, as perpetrator and/or victim, in critically ill patients, and particularly in sepsis patients. Methods: The aim of this review is to summarize the pharmacokinetic drug-drug interaction (DDI) of 45 antibiotics commonly used in sepsis care in China. Literature mining was conducted to obtain human pharmacokinetics/dispositions of the antibiotics, their interactions with drug metabolizing enzymes or transporters, and their associated clinical drug interactions. Potential DDI is indicated by a DDI index > 0.1 for inhibition or a treated-cell/untreated-cell ratio of enzyme activity being > 2 for induction. Results: The literature-mined information on human pharmacokinetics of the identified antibiotics and their potential drug interactions is summarized. Conclusion: Antibiotic-perpetrated drug interactions, involving P450 enzyme inhibition, have been reported for four lipophilic antibacterials (ciprofloxacin, erythromycin, trimethoprim, and trimethoprim-sulfamethoxazole) and three lipophilic antifungals (fluconazole, itraconazole, and voriconazole). In addition, seven hydrophilic antibacterials (ceftriaxone, cefamandole, piperacillin, penicillin G, amikacin, metronidazole, and linezolid) inhibit drug transporters in vitro. Despite no reported clinical PK drug interactions with the transporters, caution is advised in the use of these antibacterials. Eight hydrophilic antibacterials (all β-lactams; meropenem, cefotaxime, cefazolin, piperacillin, ticarcillin, penicillin G, ampicillin, and flucloxacillin), are potential victims of drug interactions due to transporter inhibition. Rifampin is reported to perpetrate drug interactions by inducing CYP3A or inhibiting OATP1B; it is also reported to be a victim of drug interactions, due to the dual inhibition of CYP3A4 and OATP1B by indinavir. In addition, three antifungals (caspofungin, itraconazole, and voriconazole) are reported to be victims of drug interactions because of P450 enzyme induction. Reports for other antibiotics acting as victims in drug interactions are scarce.

scholarly journals Clinical Pharmacokinetic Drug Interaction Potential of MenoAct851 in Adult, Female Healthy Volunteers

2021 ◽  
Vol 94 ◽  
pp. 100619
Author(s):  
Vijayakumar Thangavel Mahalingam ◽  
Ilango Kaliappan ◽  
Satish Kumar Rajappan Chandra ◽  
Melvin George ◽  
Mohan Kumar Ramasamy ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Clinical Pharmacokinetic ◽  
Adult Female ◽  
Interaction Potential ◽  
Pharmacokinetic Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals Herb–Drug Interactions: Worlds Intersect with the Patient at the Center

Medicines ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 44
Author(s):  
Mary Beth Babos ◽  
Michelle Heinan ◽  
Linda Redmond ◽  
Fareeha Moiz ◽  
Joao Victor Souza-Peres ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Case Report ◽  
Drug Interactions ◽  
Clinical Studies ◽  
Drug Information ◽  
Case Reports ◽  
Full Information ◽  
Information Need ◽  
Herbal Products ◽  
Reduce Risk

This review examines three bodies of literature related to herb–drug interactions: case reports, clinical studies, evaluations found in six drug interaction checking resources. The aim of the study is to examine the congruity of resources and to assess the degree to which case reports signal for further study. A qualitative review of case reports seeks to determine needs and perspectives of case report authors. Methods: Systematic search of Medline identified clinical studies and case reports of interacting herb–drug combinations. Interacting herb–drug pairs were searched in six drug interaction resources. Case reports were analyzed qualitatively for completeness and to identify underlying themes. Results: Ninety-nine case-report documents detailed 107 cases. Sixty-five clinical studies evaluated 93 mechanisms of interaction relevant to herbs reported in case studies, involving 30 different herbal products; 52.7% of these investigations offered evidence supporting reported reactions. Cohen’s kappa found no agreement between any interaction checker and case report corpus. Case reports often lacked full information. Need for further information, attitudes about herbs and herb use, and strategies to reduce risk from interaction were three primary themes in the case report corpus. Conclusions: Reliable herb–drug information is needed, including open and respectful discussion with patients.

Evaluation of Herbal–Drug Interaction Data in Tertiary Resources

2004 ◽  
Vol 39 (2) ◽  
pp. 149-160 ◽  
Author(s):  
Jenny R. Meyer ◽  
Joyce A. Generali ◽  
Julie L. Karpinski
Keyword(s):  
Drug Interaction ◽  
Interaction Data ◽  
Herbal Drug

Pharmacokinetic drug–drug interaction assessment of peptibody trebananib in combination with chemotherapies

2015 ◽  
Vol 76 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Benjamin Wu ◽  
Rebeca Melara ◽  
Erik Rasmussen ◽  
Lei Zhou ◽  
Teresa Wong ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals Análisis microscópico y observaciones histoquímicas de la raíz medicinal de Iostephane heterophylla (Cav.) Benth. Ex Hemsl. (Asteraceae)

2017 ◽  
pp. 65
Author(s):  
Estela Sandoval ◽  
Robert A. Bye ◽  
Griselda Ríos ◽  
María Isabel Aguilar
Keyword(s):  
Medicinal Plants ◽  
Comparative Study ◽  
Herbal Product ◽  
Raw Material ◽  
Herbal Drug ◽  
Root Structure ◽  
Fast Green ◽  
Histological Techniques ◽  
Original Contribution ◽  
Phytochemical Studies

The roots of Iostephane heterophylla are popular in Mexican traditional medicine and as such are a good candidate to develop herbal drug preparations to be used as phytomedicine. International criteria for validation and standardization of a herbal product as phytomedicine include, among others, the integration of microscopic and histochemical characteristics of the raw material, as in this case the herbal drug, to guarantee its authenticity. As an original contribution to the knowledge of the root structure of this species, fresh roots fixed in FAA, were processed with conventional histological techniques (paraffin embedment and subsequent transversal and longitudinal sections that were stained with safranin-fast green) and stained with histochemical markers for identification of cellular contents. The root description includes dermic, fundamental and vascular tissues as well as cellular contents (proteins, polysaccharides, polyphenols, condensed and hydrolyzed tannins, starches and lipids, some of which have been isolated in previous phytochemical studies). These characteristics are compared to those of other species of Asteraceae as an initial comparative study to contribute to identify medicinal plants based upon their underground parts.

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