Patient's Death Due to Another Case of Glycemic Control Problems with a Fluoroquinolone; Acute MI after OTC Pseudoephedrine Use; Asterixis Related to Gabapentin Results in Patient Falls; Antiseptic Bath Emollient Causes Acute Irritant Reaction to Genitalia; Peripheral Neuropathy with New Antifungal; Debilitating Muscle Cramps after Teriparatide Therapy Psychiatric Effects of Ephedra Use

2005 ◽  
Vol 40 (4) ◽  
pp. 304-308
Author(s):  
Joel Shuster
Keyword(s):  
Peripheral Neuropathy ◽  
Glycemic Control ◽  
Adverse Drug Reactions ◽  
Control Problems ◽  
Drug Reactions ◽  
Muscle Cramps ◽  
Patient Falls ◽  
Acute Mi

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), to discuss methods of prevention, and to promote reporting of ADRs to the FDA's medWatch program (800-FDA-1088). If you have reported an interesting preventable ADR to medWatch, please consider sharing the account with our readers.

Pulmonary Hypertension with Thalidomide Therapy; Hyperammonemia and Valproate; CNS Toxicity from Improper Use of Cyclopentolate Ophthalmic Drops; Glycemic Control Issues with Gatifloxacin; Infusion Phlebitis with Cyclosporine; Acute Hypersensitivity Reaction to HIV Fusion Inhibitor; Imatinib-Induced Hepatotoxicity

2005 ◽  
Vol 40 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Joel Shuster
Keyword(s):  
Pulmonary Hypertension ◽  
Glycemic Control ◽  
Hypersensitivity Reaction ◽  
Adverse Drug Reactions ◽  
Fusion Inhibitor ◽  
Drug Reactions ◽  
Improper Use ◽  
Infusion Phlebitis ◽  
Cns Toxicity

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), to discuss methods of prevention, and to promote reporting of ADRs to the FDA's medWatch program (800-FDA-1088). If you have reported an interesting preventable ADR to medWatch, please consider sharing the account with our readers.

scholarly journals Assessment of adverse drug reactions to antituberculosis regimen in a tertiary care hospital

2019 ◽  
Vol 8 (10) ◽  
pp. 2202
Author(s):  
Sanitha Kuriachan ◽  
Prakash Krishnan ◽  
Bharti Chogtu ◽  
Manu Mathew George
Keyword(s):  
Peripheral Neuropathy ◽  
Adverse Drug Reactions ◽  
Causality Assessment ◽  
Patient Adherence ◽  
Tertiary Care ◽  
Care Hospital ◽  
Drug Reactions ◽  
Skin Reactions ◽  
Antitubercular Treatment ◽  
Improve Patient

Background: Adverse drug reactions are common with multidrug therapy in tuberculosis, if detected early can improve patient compliance and prevent emergence of resistance.Methods: A prospective observational study as a part of Pharmacovigilance Program under Central Drugs Standard Control Organisation was conducted in Kasturba hospital, Manipal to collect adverse drug reactions (ADR). Data of patients reported with antitubercular treatment (ATT) related ADRs from September 2012 to August 2013 was evaluated for patient demography, type of tuberculosis, ATT regimen, organ/ system affected and time of onset of ADR. ADRs were then subjected to causality assessment as per WHO scale.Results: A total of 65 ADRs were reported in 60 patients during the study period, of which 46.7% were in males and 53.3% in females. 85% of ADRs were reported in patients with pulmonary tuberculosis. 77% of ADRs were observed with daily regimen. Common ADRs were hepatitis (40%), gastritis (15%), skin reactions (15%), peripheral neuropathy (14%), gout (6%) and nephritis (3%). Median duration for the onset of ADR was 31 days each for hepatitis, gout, nephritis and 20, 11, 9 days for gastritis, peripheral neuropathy and skin reactions respectively. As per causality assessment, 80% of ADRs were assigned “possible”, 11% “probable” and 9% “certain”. As per severity scale 27.7% of ADR were severe, 36.9% were moderate.Conclusions: Early detection and management of ADRs is vital for the success of ATT and patient adherence.

scholarly journals Retrospective clinical analysis of adverse drug reactions associated with antiretroviral therapy in Tlokwe district, South Africa

2018 ◽  
Vol 60 (1) ◽  
pp. 47
Author(s):  
Rentia Van Graan ◽  
Michelle Viljoen ◽  
Malie Rheeders ◽  
Fadeela Motara
Keyword(s):  
South Africa ◽  
Peripheral Neuropathy ◽  
Antiretroviral Therapy ◽  
Adverse Drug Reactions ◽  
Final Analysis ◽  
Fat Distribution ◽  
Clinical Analysis ◽  
Drug Reactions ◽  
Healthcare Facilities ◽  
Number Of Patients

Background: South Africa has the highest number of patients on antiretroviral therapy (ART) globally. Various obstacles were identified that influence effective reporting of adverse drug reactions (ADRs) in resource-limited countries. This investigation aimed to identify, classify and analyse the prevalence of ART-related ADRs. Methods: This observational, quantitative and retrospective descriptive investigation utilised ADR forms completed by healthcare professionals in various healthcare facilities in the Tlokwe district, South Africa (January 2010 to December 2014). Descriptive and inferential analyses were carried out. Results: A total of 770 ART-related ADRs were included in the final analysis. The mean age was 40.1 (± 10.1%) years, with significantly higher ADRs reported in females (70.8%). In this study, 99% of the ADRs were reported by doctors. Abnormal fat distribution (58%), peripheral neuropathy (21.6%) and renal dysfunction (6.6%) were most frequently reported. Females presented with abnormal fat distribution and peripheral neuropathy at a significantly younger age (38.1 ± 4.6 vs. 43.4 ± 5.7 years, p < 0.0001 and 39.7 ± 1.1 vs. 45.1 ± 9.2 years, p < 0.001) respectively compared with males. Gender difference was practically significant (Cramer’s V = 0.3) for all three of the major reported ADRs. Conclusions: Gender was highly dependent among the major reported ADR categories, and women presented with abnormal fat distribution and peripheral neuropathy at a significantly earlier age than males. This retrospective analysis can serve as a platform for future ADR studies within this district. Sustainable and continuous efforts should be made to train and create more awareness among healthcare workers in this district. (Full text of the research articles are available online at www.medpharm.tandfonline.com/ojfp) S Afr Fam Pract 2018; DOI: 10.1080/20786190.2017.1364013

scholarly journals Antiretroviral-induced adverse drug reactions in HIV-infected patients in Mali: a resource-limited setting experience

2019 ◽  
Vol 8 (5) ◽  
pp. 831 ◽  
Author(s):  
Aboubacar Alassane Oumar ◽  
Mamadou Dakouo ◽  
Anicet Tchibozo ◽  
Mamoudou Maiga ◽  
Guida Landouré ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peripheral Neuropathy ◽  
Adverse Drug Reactions ◽  
Female Gender ◽  
Adult Patients ◽  
Sub Saharan Africa ◽  
Hiv Care ◽  
Drug Reactions ◽  
Active Monitoring ◽  
Skin Reactions

Background: There are few reports in the literature from sub-Saharan Africa (SSA) regarding antiretroviral-induced adverse drug reactions (ADRs). Antiretroviral therapy (ART) is now widely available in SSA, and ADRs during HIV infection are also frequent. In this study, we reported the frequency and risk factors of ART-induced ADRs in a Malian population.Methods: This prospective cohort study was performed in the HIV Care and Counseling Centre (CESAC) of Mali from 2011 to 2012. Adult patients infected with HIV and who had recently started ART were included and followed-up clinically Were included in this study, adult patients living with HIV and had recently started ART who were followed up for at least 6 months to determine the incidence of ADRs using Naranjo’s classification scale.Results: During this study, 357 (42.3%) patients presented ADRs (40.1% of our patients (n=338) experienced at least one ADR, and 2.2% (n=19) experienced at least two ADRs). The prevalence of ADRs by organ system was: 45.9% neurological (n=164); 29.4% metabolic (blood chemistry) (n=105); 15.4% hematological (n=55). High probable rate of ADR was observed as indicated by the Naranjo score in 83.7% of the cases. Zidovudine (AZT) and stavudine (d4T) use was identified as a risk factor for either anaemia or peripheral neuropathy whereas nevirapine (NVP) and female gender were risk factors for skin reactions. Patients with advance disease had the highest rate of ADRs compared to the others.Conclusions: Based on the Naranjo probability scale, our data show that ADRs such as peripheral neuropathy and anemia are very frequent. These ADR was linked to AZT and D4T. Our findings highlight the need for active monitoring, continuous pharmacovigilance of ART and change of some ART drug in this population.

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