Community participation as a predictor of depressive symptoms among individuals with serious mental illnesses

2021 ◽  
pp. 002076402110521
Author(s):  
Shinichi Nagata ◽  
Bryan McCormick ◽  
Eugene Brusilovskiy ◽  
Mark S Salzer

Background: People with serious mental illnesses have elevated levels of depressive symptoms. Limited engagement in meaningful activities, such as work, social interactions, volunteering, and participation in faith, are one plausible explanation for this. Increased community participation over time may be associated with decreased depressive symptoms. Aim: Examine whether an increase in participation over time predicts a decrease in depression after controlling for depression at the baseline. Methods: Participants were 183 adults with schizophrenia spectrum, bipolar disorder, or major depressive disorder who completed the Hopkins Symptom Index – Depression subscale and the Temple University Community Participation Measure. Participants completed these measures at baseline and either a 12- or 24-month follow-up timepoint. Multiple regression analyses were conducted with the depression score as a dependent variable and changes in community participation as a predictor variable. Demographics, baseline depression score, and time interval between baseline and last observation were entered as control variables. Results: Endorsing more activities as important, participating in more important areas that are important, and participating ‘enough’ in more important areas over time were each significant predictors of decreases in depression. Conclusion: These findings enhance the connection between community participation and depression and suggest that a focus on participation may be important in terms of boosting both community functioning and treatment goals.

Author(s):  
Shinichi Nagata ◽  
Bryan McCormick ◽  
Eugene Brusilovskiy ◽  
Gretchen Snethen ◽  
Greg Townley ◽  
...  

2017 ◽  
Vol 41 (S1) ◽  
pp. S307-S307
Author(s):  
E. Van Assche ◽  
E. Vangeel ◽  
K. Freson ◽  
K. Van Leeuwen ◽  
K. Verschueren ◽  
...  

IntroductionAdolescents’ well being is affected by their parenting situation and can influence their well being over time. We present an exploratory study with an Illumina 450 k array, comparing methylation in adolescents, based on perceived parenting at T0, and how methylation can interact with parenting in explaining depressive symptoms two years later (T2).ObjectivesIdentify differentially methylated regions (DMRs) associated with perceived parenting at T0 and investigate their association with depressive symptoms two years later.AimsAn exploratory analysis evaluating the association between methylation and depressive symptoms longitudinally.MethodsFrom two extreme parenting clusters: perceived supportive, and punishing neglecting, we randomly selected 44 adolescents (MAge = 14 at T0; 48%boys). The CES-D scale (Center for Epidemiologic Studies Depression Scale) assessed depressive symptoms. DMRs were identified based on the parenting clusters (DMRcate and comb-p) using llumina Infinium HumanMethylation 450 BeadChip data. Associations between the most significant CpG for each DMR and the depression score at T2, were calculated using linear regression analysis.ResultsWe identified 17 DMRs, but only cg13306335 in PEX10 was associated with depressive symptoms at T2 (P = 0.0014, Bonferroni (17 tests): P < 0.0029). Additionally, an interaction between parenting at T0 and PEX10 methylation (T0) in explaining depressive symptoms (T2) can be suggested (P = 0.014).ConclusionsWe show that methylation at PEX10's most significant CpG is correlated with depressive symptoms at T2, these exploratory results also suggest a possible interaction between parenting and PEX10 methylation at T0 in association with depressive symptoms at T2. Validation in a larger sample is needed to support the role of methylation and its interactions in depression over time.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2021 ◽  
Vol 20 ◽  
pp. 100381
Author(s):  
Gretchen Snethen ◽  
Eugene Brusilovskiy ◽  
Bryan P. McCormick ◽  
Shiv V. Hiremath ◽  
Mark S. Salzer

2006 ◽  
Vol 29 (3) ◽  
pp. 189-196 ◽  
Author(s):  
Nadine Larivière ◽  
Isabelle Gélinas ◽  
Barbara Mazer ◽  
Beverlea Tallant ◽  
Isabelle Paquette

Author(s):  
Uma Chandrika Millner ◽  
Tracy Woods ◽  
Kathleen Furlong‐Norman ◽  
E. Sally Rogers ◽  
Dennis Rice ◽  
...  

2019 ◽  
Vol 70 (8) ◽  
pp. 689-695 ◽  
Author(s):  
Greg Townley ◽  
Rachel Terry ◽  
Eugene Brusilovskiy ◽  
Gretchen Snethen ◽  
Mark S. Salzer

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