Human Papillomavirus Infection and Its Association with HIV

2011 ◽  
Vol 23 (1) ◽  
pp. 84-89 ◽  
Author(s):  
S. Syrjänen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Antiretroviral Therapy ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Squamous Cell ◽  
Highly Active Antiretroviral Therapy ◽  
Case Control Studies ◽  
Highly Active ◽  
Increased Risk

Human papillomavirus (HPV) can infect oral mucosa, causing asymptomatic infection or warty lesions. Several case-control studies have confirmed HPV as an independent risk factor for squamous cell carcinoma. HPV-related cancers seem to have better prognoses and different risk factors than do HPV-negative ones. HIV-infected patients are known to be at increased risk for persistent genital and anal high-risk HPV infections and intraepithelial neoplasm. Since the era of highly active antiretroviral therapy, the prevalence and persistence of warty lesions in oral mucosa have increased. Oral squamous cell carcinoma was recently added in the case definitions for common HIV-related oral mucosa lesions. The increased risk of HPV infection in HIV patients has been associated with impaired immune response to HPV, highly active antiretroviral therapy, aging of the HIV-infected patients, and direct interaction between the 2 viruses. HPV32 seems to be much more prevalent in asymptomatic HPV infections and warts among those infected with HIV than among those in the general population. Regarding HIV genes, there is evidence of an interaction between HPV and tat, rev, and vpr. HIV might play a role in HPV-associated pathogenesis by exhorting oncogenic stimuli via tat and rev or visa versa.

Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit

2011 ◽  
Vol 126 (3) ◽  
pp. 276-278 ◽  
Author(s):  
F M A Butt ◽  
M L Chindia ◽  
F Rana
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Highly Active Antiretroviral Therapy ◽  
Histopathological Classification ◽  
Highly Active ◽  
Increased Risk ◽  
Immunodeficiency Virus

AbstractBackground:Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives.Aim:To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus.Study design:Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus.Results:Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18–43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification).Conclusion:Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.

scholarly journals Association of HIV Status With Outcomes of Anal Squamous Cell Carcinoma in the Era of Highly Active Antiretroviral Therapy

JAMA Oncology ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 120 ◽  
Author(s):  
Alex K. Bryant ◽  
Minh-Phuong Huynh-Le ◽  
Daniel R. Simpson ◽  
Samir Gupta ◽  
Andrew B. Sharabi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Antiretroviral Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Highly Active Antiretroviral Therapy ◽  
Hiv Status ◽  
Anal Squamous Cell Carcinoma ◽  
Highly Active

scholarly journals Squamous Cell Carcinoma of the Lower Lip Complicating a Recurrent Labial Herpes During HIV Infection: a Case Report

2020 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Hiv Infection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Highly Active Antiretroviral Therapy ◽  
Surgical Excision ◽  
Hiv Positive ◽  
Epithelial Tumor ◽  
Lower Lip ◽  
Highly Active

Introduction: Squamous cell carcinoma (SCC) is the main cancer of lips; it is increasingly diagnosed in HIV-positive patients. In most cases, there are factors that promote his occurrence. We report a case of an HIV-positive woman with SCC of the lower lip complicating recurrent labial herpes. Medical observation: It was a case of a 40-year-old female received in consultation for a painful and ulcerous lesion of her lip lasting 5 months. She was a HIV-positive patient diagnose since 2007 and on Highly Active Antiretroviral Therapy since that time. She was taking alcohol, was exposed to sunlight regularly, and had presented many episodes of labial herpes in the past. On clinical examination she had a painful ulcero-crustal medallion measuring 2.5 centimeters in diameter, with a papular edge of pearlescent appearance of the lower lip. Given this clinical picture, the diagnosis of chronic decaying herpes labialis with in differential an epithelial tumor (in particular a squamous cell carcinoma of the lower lip) was mentioned. After surgical excision, an anatomopathological analysis of the part confirmed the diagnosis of squamous cell carcinoma. At the time of diagnosis, the patient had a respective CD4 and CD8 level of 939 and 964 cells / mm3 . The evolution was marked 6 weeks later by the scarring with complete epithelialization of the site of the lesion. Conclusion: SCC of the lips is a frequent cancer occurring during HIV infection; there are many risk factors which promote his occurrence. Earlier the treatment is instituted, better is the prognosis.

Prevalence and Association of Human Papillomavirus with Esophageal Squamous Cell Carcinoma in Iran: A Systematic Re-view and Meta-Analysis

2020 ◽  
Author(s):  
Bashir MOHAMMADPOUR ◽  
Samaneh ROUHI ◽  
Mazaher KHODABANDEHLOO ◽  
Masoud MORADI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Total Prevalence

Background: Human papillomavirus (HPV) can infect the epithelium of the esophagus, but so far there is no reliable and comprehensive evidence about the prevalence and association of HPV with esophageal cancer in Iran, as high incidence region. This study aimed to evaluate the prevalence and association of HPV with esophageal squamous cell carcinoma (ESCC) in Iran. Methods: Relevant English and Persian articles published up to Aug 2017 and indexed in databases were reviewed. Frequency of HPV genotypes in ESCC cases and controls was surveyed according to regions of Iran. Data were meta-analyzed with random effects models using Comprehensive Meta-Analysis software. Results: Overall, 14 studies were eligible including 1444 samples (1062 ESCC cases and 382 controls). HPV was positive in 269 (25.32%) of 1062 ESCC cases and in 65 (17.01%) of 382 controls. Total prevalence of HPV in both groups was estimated 0.256 (95%CI, 0.208%-0.310%). The prevalence of HPV-16 and HPV-18 was estimated 0.121 (95%CI: 0.087-0.183) and 0.046 (95%CI; 0.023-0.088), respectively. The difference in HPV prevalence in different regions of Iran was statistically significant (Q=18.20, df =4, P=0.001). In 6 case-control studies, the pooled odds ratio was estimated 1.99 (95%CI; 0.916-4.315). Conclusion: High-risk HPVs were observed in ESCC cases and controls from different regions of Iran. The odds ratio indicates that the HPV infection in ESCC cases was approximately 2 fold more than the controls. More case-control studies in other populations with larger sample size are necessary.

scholarly journals Non-AIDS Defining Malignancies Become an Emerging Problem in HIV-Infected Patients

2016 ◽  
Author(s):  
Khin Soe ◽  
Zaw Moe Thein
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Antiretroviral Therapy ◽  
Oral Squamous Cell Carcinoma ◽  
Hiv Infection ◽  
Cell Carcinoma ◽  
Highly Active Antiretroviral Therapy ◽  
Oral Pathology ◽  
Highly Active ◽  
Screening Procedures

The introduction of HAART (Highly Active Antiretroviral Therapy) caused significant decrease in the incidence of AIDS-defining illnesses among individuals undergoing antiretroviral therapy. In the resent years, the research observed a worrying increase in the incidence of non-AIDS-defining illnesses and increases mortality related to these cases. In this retrospective study, we observed surgical pathology cases with HIV infection those sent to Oral Pathology Unit, University of Dental Medicine, Yangon, from January 2013 to November 2015. Twelve cases were analyzed in relation with their request forms and biopsy results. In general, there were noticeably larger numbers of non-AIDS-defining malignancies (for instance, oral squamous cell carcinoma). According to this study, non-AIDS-defining malignancy is found to be an emerging problem in HIV-infected patients. Further epidemiological and clinico-pathological studies as well as screening procedures should be warranted to solve this problem.

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