scholarly journals Precision Health: Bringing Oral Health into the Context of Overall Health

2019 ◽  
Vol 30 (2) ◽  
pp. 31-33 ◽  
Author(s):  
L. Tabak ◽  
E. Green ◽  
S. Devaney ◽  
M. Somerman

Unprecedented advances in genomics, data science, and biotechnology have ushered in a new era of health care in which interventions are increasingly tailored to individual patients. Precision-based approaches extend to oral health, which is essential to overall health. Harnessing the full potential of precision oral health will depend on research to more fully understand the factors that underlie health and contribute to disease—including the human genome, microbiome, epigenome, proteome, and others.

2020 ◽  
Vol 78 (Supplement_3) ◽  
pp. 53-57
Author(s):  
Seiya Imoto ◽  
Takanori Hasegawa ◽  
Rui Yamaguchi

Abstract Precision health care plays a crucial role in an elderly society by providing personalized health care plans for improving an individual’s health conditions and preventing disease. To realize precision health care, data science is key; it allows for analyses of health-related big data. In this article, an actual analysis of time-series health check-up data is presented and as is a discussion of how personalized simulation models of health conditions are constructed and used to modify individual behavior. Future directions for precision health care based on the integration of genetic variations and the microbiome are also discussed.


2019 ◽  
Vol 98 (9) ◽  
pp. 949-955 ◽  
Author(s):  
K. Divaris

Understanding the “code of life” and mapping the human genome have been monumental and era-defining scientific landmarks—analogous to setting foot on the moon. The last century has been characterized by exponential advances in our understanding of the biological and specifically molecular basis of health and disease. The early part of the 20th century was marked by fundamental theoretical and scientific advances in understanding heredity, the identification of the DNA molecule and genes, and the elucidation of the central dogma of biology. The second half was characterized by experimental and increasingly molecular investigations, including clinical and population applications. The completion of the Human Genome Project in 2003 and the continuous technological advances have democratized access to this information and the ability to generate health and disease association data; however, the realization of genomic and precision medicine, to practically improve people’s health, has lagged. The oral health domain has made great strides and substantially benefited from the last century of advances in genetics and genomics. Observations regarding a hereditary component of dental caries were reported as early as the 1920s. Subsequent breakthroughs were made in the discovery of genetic causes of rare diseases, such as ectodermal dysplasias, orofacial clefts, and other craniofacial and dental anomalies. More recently, genome-wide investigations have been conducted and reported for several diseases and traits, including periodontal disease, dental caries, tooth agenesis, cancers of the head and neck, orofacial pain, temporomandibular disorders, and craniofacial morphometrics. Gene therapies and gene editing with CRISPR/Cas represent the latest frontier surpassed in the era of genomic medicine. Amid rapid genomics progress, several challenges and opportunities lie ahead. Importantly, systematic efforts supported by implementation science are needed to realize the full potential of genomics, including the improvement of public and practitioner genomics literacy, the promotion of individual and population oral health, and the reduction of disparities.


1988 ◽  
Vol 52 (11) ◽  
pp. 637-642 ◽  
Author(s):  
TA Dolan ◽  
CR Corey ◽  
HE Freeman

1993 ◽  
Vol 32 (04) ◽  
pp. 265-268 ◽  
Author(s):  
D. J. Essin

AbstractLoosely structured documents can capture more relevant information about medical events than is possible using today’s popular databases. In order to realize the full potential of this increased information content, techniques will be required that go beyond the static mapping of stored data into a single, rigid data model. Through intelligent processing, loosely structured documents can become a rich source of detailed data about actual events that can support the wide variety of applications needed to run a health-care organization, document medical care or conduct research. Abstraction and indirection are the means by which dynamic data models and intelligent processing are introduced into database systems. A system designed around loosely structured documents can evolve gracefully while preserving the integrity of the stored data. The ability to identify and locate the information contained within documents offers new opportunities to exchange data that can replace more rigid standards of data interchange.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1473-1476
Author(s):  
Ashwika Datey ◽  
Soumya Singhai ◽  
Gargi Nimbulkar ◽  
Kumar Gaurav Chhabra ◽  
Amit Reche

The COVID 19 outbreak has been declared a pandemic by the world health organisation. The healthcare sector was overburdened and overstretched with the number of patient increasing and requiring health services. The worst-hit population always are the people with special needs, whether it is children, pregnant females or the geriatric population. The need for the emergency kind of health services was so inflated that the other special population which required them equally as those patients with the COVID 19 suffered a lot. Dentistry was not an exception, and even that is also one of the important components of the health care delivery system and people requiring oral health care needs were also more. Those undergoing dental treatments would not have completed the treatment, and this would have resulted in various complications. In this situation, some dental emergency guidelines have been released by Centres for Disease Control (CDC) for the urgent dental care those requiring special care dentistry during the COVID 19 pandemic. Children with special care needs were considered more vulnerable to oral diseases; hence priority should have been given to them for dental treatments moreover in the future also more aggressive preventive measures should be taken in order to maintain oral hygiene and prevent many oral diseases. Guardians/caregivers should be made aware and motivated to maintain the oral health of children with special health care needs. This review mainly focuses on the prevention and management of oral diseases in children's with special care needs.


2019 ◽  
Vol 9 (1) ◽  
pp. 01-04
Author(s):  
Saritha Maloth ◽  
◽  
Archana Archana Mukunda ◽  
Shrinivas TR ◽  
◽  
...  

2020 ◽  
Vol 4 (5) ◽  
pp. 18-22
Author(s):  
Subhathira Rajasekaran ◽  
Sham S Bhat ◽  
Vidya Bhat ◽  
Sundeep Hegde K ◽  
Neha Thilak ◽  
...  

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