Oral Submucous Fibrosis as a Precancerous Condition

1966 ◽  
Vol 45 (3) ◽  
pp. 546-553 ◽  
Author(s):  
Jens J. Pindborg
Keyword(s):  
Oral Submucous Fibrosis ◽  
Precancerous Condition ◽  
Submucous Fibrosis

scholarly journals Prevalence of OSMF cases in various age groups correlating with habits and treatment outcomes in Saveetha Dental College: A prevalence study

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1799-1804
Author(s):  
Aklesha Behera ◽  
Abilasha R ◽  
Pratibha Ramani ◽  
Gheena S ◽  
Hannah R
Keyword(s):  
Indian Subcontinent ◽  
Oral Submucous Fibrosis ◽  
Age Groups ◽  
Mouth Opening ◽  
Study Groups ◽  
Patient Records ◽  
Tobacco Products ◽  
Precancerous Condition ◽  
Male Preponderance ◽  
Submucous Fibrosis

Oral submucous fibrosis is a chronic, progressive, scarring precancerous condition of the oral cavity seen predominantly in the Indian subcontinent and southeast Asia. OSMF is caused by consumption of areca nuts and tobacco products. Patients suffer from trismus and other related problems. Interincisal mouth opening ranges between 24 to 55 mm in this study, hence making the study groups between I to III. The aim of the study is to find a correlation between age, habits and treatment outcome in OSMF patients. Data was procured from patient records of 86000 patients who visited from between June 2019 and March 2020 and analysis was done. Age is between 21 to 64 years. Male preponderance is seen 92.4% pan chewing is common (35.9%) Interincisal opening is between 24 to 55 mm, making the OSMF grade I and II. OSMF affects people aged 21 to 64 years and the interincisal mouth opening is between 24 to 55 mm, making the grades I and II.

scholarly journals The Use of Diode Laser in Treatment of Oral Submucous Fibrosis

2016 ◽  
Vol 1 (2) ◽  
pp. 79-81
Author(s):  
Amit LNU ◽  
Ashish Soni ◽  
Prateek Agarwal
Keyword(s):  
Surgical Treatment ◽  
Diode Laser ◽  
Local Anesthesia ◽  
Indian Subcontinent ◽  
Diode Lasers ◽  
Oral Submucous Fibrosis ◽  
Treatment Modalities ◽  
Success Rates ◽  
Precancerous Condition ◽  
Submucous Fibrosis

ABSTRACT Oral submucous fibrosis (OSMF) is an established precancerous condition with increased prevalence in the Indian subcontinent. The treatment of OSMF is a challenging task for a clinician. Different authors have suggested variety of treatment modalities and have claimed success rates; still there is no universally acceptable protocol for the management of OSMF. In our case, transaction of bands was done by contact diode lasers (12 watt) under local anesthesia and it offered good results. Diode lasers offered excellent results and had many advantages over conventional surgical treatment. How to cite this article Soni A, Sharma S, Chitlangia P, Amit, Agarwal P. The Use of Diode Laser in Treatment of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(2):79-81.

scholarly journals Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Meghanand T. Nayak ◽  
Anjali Singh ◽  
Rajiv S. Desai ◽  
S. S. Vanaki
Keyword(s):  
Oral Submucous Fibrosis ◽  
Immunohistochemical Analysis ◽  
Staining Intensity ◽  
Immunohistochemical Expression ◽  
Vimentin Expression ◽  
Future Studies ◽  
Precancerous Condition ◽  
Abnormal Accumulation ◽  
Submucous Fibrosis ◽  
Tumour Differentiation

Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation.Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF.Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa.Results. The overall staining intensity of vimentin significantly increased statistically (P<0.01) in OSF cases over normal control. A significant increase in the staining intensity of vimentin was also noted in the fibroblasts of severe cases of OSF (P=0.03).Conclusion. Considering the marked vimentin expression in the present study, future studies should include cytoskeleton IF and other filaments in the fibroblasts of OSF.

scholarly journals Recent Advancements in Oral Submucous Fibrosis Management: an Overview

2014 ◽  
Vol 4 (2) ◽  
pp. 88-90 ◽  
Author(s):  
M Gupta ◽  
A Pachauri ◽  
SK Singh ◽  
R Ahuja ◽  
P Singh ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Dental Research ◽  
Precancerous Condition ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
The Subject ◽  
Research And Education

The management of Oral submucous fibrosis has been the subject of controversy ever since Schwartz first described the condition in 1952. It is potentially malignant disorder and crippling condition of oral mucosa. An attempt is made update the knowledge about the management of this precancerous condition with advancements which helps to reduce the mortality of oral cancer. DOI: http://dx.doi.org/10.3329/bjdre.v4i2.20256 Bangladesh Journal of Dental Research and Education Vol.4(2) 2014: 88-90

Oral submucous fibrosis as a precancerous condition

1984 ◽  
Vol 92 (3) ◽  
pp. 224-229 ◽  
Author(s):  
J. J. PINDBORG ◽  
P. R. MURTI ◽  
R. B. BHONSLE ◽  
P. C. GUPTA ◽  
D. K. DAFTARY ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Precancerous Condition ◽  
Submucous Fibrosis

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

Localized peripheral autonomous neuropathy and dysfunctional myoepithelial cells: A novel hypothesis for xerostomia in oral submucous fibrosis

2020 ◽  
Vol 144 ◽  
pp. 109998
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Amol Gadbail ◽  
Shailesh Gondivkar ◽  
Shankargouda Patil
Keyword(s):  
Oral Submucous Fibrosis ◽  
Myoepithelial Cells ◽  
Submucous Fibrosis
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