Mitotic Activity in the Oral Epithelium of the Albino Rat

1976 ◽  
Vol 55 (5) ◽  
pp. 859-863 ◽  
Author(s):  
P. Cleaton-Jones
Keyword(s):  
Mitotic Activity ◽  
Soft Palate ◽  
Wistar Rats ◽  
Hard Palate ◽  
Oral Epithelium ◽  
Albino Rat

In groups of Wistar rats 3 and 12 months of age, colchicine and radioautography were used to assess mitotic activity in oral epitheliums. Apparent mitotic activity in the epitheliums of the cheek, hard palate, and central, intermediate, and lateral zones of the soft palate depended on the method used and the age of the rat.

The influence of the epithelium on palate shelf reorientation

Development ◽  
1985 ◽  
Vol 88 (1) ◽  
pp. 265-279
Author(s):  
Robert F. Bulleit ◽  
Ernest F. Zimmerman
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Basement Membrane ◽  
Soft Palate ◽  
Hard Palate ◽  
Significant Inhibition ◽  
Oral Epithelium ◽  
Secondary Palate ◽  
Intrinsic Forces

The intrinsic forces necessary for directing the reorientation of the secondary palate appear to reside in the anterior two thirds of the palate or presumptive hard palate. The hard palate could reorient regardless of whether it was intact or separated from the posterior third or presumptive soft palate. The soft palate could only reorient if the palate shelves are left intact. These intrinsic forces, within the hard palate, may be mediated by the mesenchymal cells, their extracellular matrix, or the epithelium surrounding the shelves. This latter possibly was tested by removing the epithelium, from either the presumptive oral or nasal surface followed by measurement of reorientation in vitro. Only after removal of the oral epithelium was a significant inhibition in reorientation observed. The treatment used to remove the epithelium, EDTA and scraping, was shown to remove 41 % of the oral epithelium leaving the majority of the basement membrane intact. The observed inhibition of reorientation did not appear to be a consequence of wound healing. Creation of wounds twice the area that was observed after treatment with EDTA and scraping inhibited reorientation minimally. These results suggest that the epithelium and particularly the anterior oral epithelium plays a major role in the reorientation of the murine secondary palate.

Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate

2019 ◽  
Vol 57 (4) ◽  
pp. 420-429
Author(s):  
Susanna Botticelli ◽  
Annelise Küseler ◽  
Kirsten Mølsted ◽  
Helene Soegaard Andersen ◽  
Maria Boers ◽  
...  
Keyword(s):  
Soft Palate ◽  
Hard Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Controlled Trial ◽  
Velopharyngeal Insufficiency ◽  
Primary Surgery ◽  
Multicenter Randomized Controlled Trial ◽  
Palate Repair ◽  
Velopharyngeal Function

Aim: To examine the association of cleft severity at infancy and velopharyngeal competence in preschool children with unilateral cleft lip and palate operated with early or delayed hard palate repair. Design: Subgroup analysis within a multicenter randomized controlled trial of primary surgery (Scandcleft). Setting: Tertiary health care. One surgical center. Patients and Methods: One hundred twenty-five infants received cheilo-rhinoplasty and soft palate repair at age 3 to 4 months and were randomized to hard palate closure at age 12 or 36 months. Cleft size and cleft morphology were measured 3 dimensionally on digital models, obtained by laser surface scanning of preoperative plaster models (mean age: 1.8 months). Main outcome measurements: Velopharyngeal competence (VPC) and hypernasality assessed from a naming test (VPC-Sum) and connected speech (VPC-Rate). In both scales, higher scores indicated a more severe velopharyngeal insufficiency. Results: No difference between surgical groups was shown. A low positive correlation was found between posterior cleft width and VPC-Rate (Spearman = .23; P = .025). The role of the covariate “cleft size at tuberosity level” was confirmed in an ordinal logistic regression model (odds ratio [OR] = 1.17; 95% confidence interval [CI]:1.01-1.35). A low negative correlation was shown between anteroposterior palatal length and VPC-Sum (Spearman = −.27; P = .004) and confirmed by the pooled scores VPC-Pooled (OR = 0.82; 95% CI: 0.69-0.98) and VPC-Dichotomic (OR = 0.82; 95% CI: 0.68-0.99). Conclusions: Posterior cleft dimensions can be a modest indicator for the prognosis of velopharyngeal function at age 5 years, when the soft palate is closed first, independently on the timing of hard palate repair. Antero-posterior palatal length seems to protect from velopharyngeal insufficiency and hypernasality. However, the association found was significant but low.

The State of the Art in Cleft Palate Surgery

2000 ◽  
Vol 37 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Don Larossa
Keyword(s):  
Cleft Palate ◽  
Soft Palate ◽  
Hard Palate ◽  
Surgical Repair ◽  
State Of The Art ◽  
Historical Context ◽  
Current Understanding ◽  
Multiple Methods ◽  
Advantages And Disadvantages ◽  
Palate Repair

Overview This update focuses on current practices and controversies in surgical repair of the hard and soft palate posterior to the alveolus. Our current understanding of the advantages and disadvantages of presurgical active and passive manipulation of the hard palate shelves including the use of periosteoplasty is reviewed. The evolution of the multiple methods of repair of the hard and soft palate is given in a historical context along with a discussion of the concerns about timing of palate repair.

Complete Agenesis of the Soft Palate

2001 ◽  
Vol 38 (4) ◽  
pp. 410-412
Author(s):  
Jeffrey A. Ascherman ◽  
Valerie A. Jones ◽  
Robert A. Manduley ◽  
Kwame Yeboa
Keyword(s):  
Soft Palate ◽  
Hard Palate ◽  
Physical Characteristics ◽  
Rare Finding

Objective: This report documents the physical characteristics and treatment of a patient with the extremely rare finding of complete agenesis of the soft palate. The posterior hard palate cleft and soft palate agenesis were treated with a palatal pushback procedure.

Histologic Study of Intravelar Structures in Normal Human Adult Specimens

2005 ◽  
Vol 42 (5) ◽  
pp. 481-489 ◽  
Author(s):  
David P. Kuehn ◽  
Jerald B. Moon
Keyword(s):  
Soft Palate ◽  
Hard Palate ◽  
Tissue Composition ◽  
Posterior Border ◽  
Histologic Study ◽  
Levator Veli Palatini ◽  
Composition And Structure ◽  
Uniform Function ◽  
Substantial Investment ◽  
Normal Human

Objective To describe more clearly the tissue composition and structure of the human soft palate with particular emphasis on the central portion between the faucial pillars. Specimens Nine female and three male normal adult human soft palate cadaver specimens. Results The anterior soft palate consists of fairly uniform layers. The anterior one fourth contains a substantial investment of mucous-secreting glandular tissue, as well as an abundance of adipose tissue. The tensor veli palatini tendon is prominent in the most anterior region just posterior to the hard palate and close to the nasal surface. The middle one third of the soft palate is largely invested with muscle tissue consisting of (1) levator veli palatini fibers coursing transversely across the midline without a septal interruption, (2) musculus uvulae fibers encapsulated in a sheath and coursing longitudinally, perpendicular to and cradled by the levator sling, and (3) palatopharyngeus fibers located laterally and not approaching the midline. Musculus uvulae is variable across and within specimens in terms of its paired versus unpaired nature. Conclusions The anatomy of the soft palate from the posterior border of the hard palate to the levator veli palatini sling is consistent among specimens, suggesting that structures in this region have a uniform function across subjects. The paired versus unpaired nature of musculus uvulae is variable both within and between specimens. The posterior one third of the soft palate is variable across specimens with regard to the relative amount and distribution of different tissue types.

Anterior approach to recurrent chordomas of the clivus

1972 ◽  
Vol 36 (5) ◽  
pp. 670-672 ◽  
Author(s):  
A. N. Guthkelch ◽  
R. G. Williams
Keyword(s):  
Soft Palate ◽  
Anterior Approach ◽  
Hard Palate ◽  
Content Type ◽  
Recurrent Tumors ◽  
Mucosal Incision ◽  
Fine Print

✓ A modified transpalatal transclival approach was used for removal of two recurrent tumors of the clivus. New features of the exposure include placing the mucosal incision immediately behind the line of the upper teeth, removal of the posterior third of the hard palate, increased mobilization of the soft palate, and removing the posterior ends of the inferior turbinals.

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