Role of Parotid Amylase in Starch Digestion in the Gastro-intestinal Tracts of Diabetic Rats

1989 ◽  
Vol 68 (9) ◽  
pp. 1366-1369 ◽  
Author(s):  
M. Kurahashi ◽  
K. Inomata
Keyword(s):  
Intestinal Tract ◽  
Amylase Activity ◽  
Diabetic Rats ◽  
Starch Digestion ◽  
Parotid Glands ◽  
Parotid Duct ◽  
Duct Ligation ◽  
Intestinal Contents ◽  
Gastro Intestinal Tract

In order for the role of parotid amylase in starch digestion in the gastro-intestinal tracts of diabetic rats to be clarified, this study investigated the effect of parotid-duct ligation on both amylase secretion from the parotid glands and pancreas into the gastro-intestinal tract and on starch digestion in the gastro-intestinal contents during feeding. In both diabetic rats and control rats, parotid-duct ligation reduced amylase activity in both the parotid glands during fasting and in the gastric contents after feeding. The amylase activity in the intestinal contents after feeding was reduced by parotid-duct ligation in the diabetic rats. Starch digestion in the gastro-intestinal tract after feeding was reduced by parotid-duct ligation in the diabetic rats. The results suggest that most of the amylase activity in the gastric contents and a large part of the amylase activity in the intestinal contents are derived from the parotid glands, and that parotid amylase plays an important role in starch digestion in the gastro-intestinal tracts of diabetic rats.

Amylase secretion by parotid glands and pancreas of diabetic rats during feeding

1988 ◽  
Vol 254 (6) ◽  
pp. G878-G882 ◽  
Author(s):  
M. Kurahashi ◽  
K. Inomata
Keyword(s):  
Gastrointestinal Tract ◽  
Gastric Content ◽  
Amylase Activity ◽  
Diabetic Rats ◽  
Amylase Secretion ◽  
Pancreatic Amylase ◽  
Parotid Glands ◽  
Appreciable Change ◽  
Intestinal Contents ◽  
Small Intestinal

Parotid and pancreatic amylase secretion into the gastrointestinal tract during feeding was investigated in diabetic rats. In control rats, both parotid and pancreatic amylase activity decreased after feeding, while the amylase activity present in the gastric and small intestinal contents increased. In diabetic rats, parotid amylase activity, although reduced from control levels, decreased after feeding, and amylase activity of the parotid type appeared in the gastric content. Amylase activities in the diabetic pancreas and small intestinal contents at fasting were markedly reduced and did not show appreciable change with feeding. The total amylase activity in the small intestinal contents after feeding was markedly reduced in the diabetic rats, whereas the ratio of parotid to pancreatic amylase was markedly increased. These results suggest that the amylase secreted from the parotid glands into the gastrointestinal tract during feeding acts not only in the mouth and stomach but also in the small intestine of diabetic rats.

scholarly journals Observations on the fermentation of carbohydrates along the gastro-intestinal tract of a fistulated cow.

1973 ◽  
Vol 21 (3) ◽  
pp. 217-226
Author(s):  
B.D.E. Gaillard ◽  
A.T. van 't Klooster
Keyword(s):  
Small Intestine ◽  
Intestinal Tract ◽  
Soluble Fraction ◽  
Soluble Sugars ◽  
Water Soluble ◽  
Uronic Acids ◽  
Glucose Polymer ◽  
Intestinal Contents ◽  
Cellulose Fermentation ◽  
Gastro Intestinal Tract

One cow was provided with cannulae in the proximal duodenum and terminal ileum. Three experimental rations were offered: 1, hay 7 kg/day and concentrate 6; 2, hay 3 kg/day, paper pulp 3 and concentrate 3.7; 3, fresh grass 11 kg DM/day. Rations 2 and 2 were given twice daily and 3 was offered more frequently. Experimental periods were 5 days in experiment 1 and 7 days in 2 and 3. Samples were taken from each cannula every 2 h for 5 days. Faeces were collected in each period. Flow rate of the intestinal contents was measured with polyethylene glycol and chromium sesquioxide as markers. Carbohydrates in the feed, digesta and faeces were fractionated according to solubility into ethanol-soluble sugars, alpha -glucose polymers, fructosan, water-soluble polysaccharides other than alpha -glucose polymers and fructosan, neutral-detergent-soluble polysaccharides and neutral-detergent residue. Sugars, sialic and uronic acids were measured in the hydrolysates and the sugars were separated chromatographically.Most of the ethanol-soluble sugars and all the fructosan was digested in the rumen, reticulum, omasum and abomasum, considered collectively as the stomach. Digestion of alpha -glucose polymer occurred mainly in the stomach and only 5 to 10% was digested in the small intestine and caecum with colon. The hay and concentrate ration contained more starch than the others and a higher proportion of this was digested in the small intestine and caecum with colon (20.3 and 6.8% of the digestible starch). The water-soluble fraction was digested mostly in the stomach; on rations 1 and 3 more component carbohydrates disappeared from the small intestine than the caecum with colon. Bacterial polysaccharides were thought to be digested in the small intestine and some bacterial growth was indicated, particularly on ration 2 which contained large amounts of cellulose. Fermentation and addition of bacterial polysaccharides and mucus confused the picture of digestion of the neutral-detergent-soluble fraction, but on all 3 rations it was higher in the small intestine than in the caecum with colon. The neutral-detergent residue was mainly fermented in the stomach and the caecum with colon. (Abstract retrieved from CAB Abstracts by CABI’s permission)

scholarly journals INTERACTION OF THE SYMBIOTIC MICROBIOTA OF THE GASTRO-INTESTINAL TRACT WITH THE NERVOUS SYSTEM OF THE HOST ORGANISM

2019 ◽  
Vol 1 (2) ◽  
pp. 90-100
Author(s):  
A V Oleskin
Keyword(s):  
Nervous System ◽  
Intestinal Tract ◽  
Distal Part ◽  
Human Organism ◽  
Gi Tract ◽  
Physical And Mental Health ◽  
Gi Symptoms ◽  
Gastro Intestinal Tract ◽  
Symbiotic Microbiota

Symbiotic microorganisms inhabit a wide variety of niches in the human organism. Of paramount importance is the microbiota of the gastro-intestinal (GI) tract, especially of its distal part (the colon). Bidirectional signal exchange proceeds within the microbiota-host system, and diverse microbial metabolites modify the functions of the nervous system via metabolic, genetic, and neuroendocrine pathways. Increasing attention is currently given to the role of the GI microbiota in terms of the host's physical and mental health; therefore, it has been suggested to replace the widely used term gut-brain axis with the new term microbiota-gut-brain axis. The GI microbiota directly interacts with the enteric nervous system (ENS) that represents a partly autonomous subdivision of the nervous system. An important role is also played by the GI tract-innervating vagus nerve. In addition, the influence of the microbiota on the nervous system can be mediated by the immune system. The microbiota impact on the nervous system of the host results in significant alterations in the host's behavior, mood, and even taste. In the literature, there is evidence that neurological and psychological diseases are linked to microecological disorders (dysbioses) in the GI tract. In particular, dysbioses with manifest GI symptoms are often accompanied by serious brain problems.

scholarly journals The role of endoscopic ultrasound(EUS) in differential diagnosis of subepithelial oesophago-gastric lesions

2005 ◽  
Vol 52 (1) ◽  
pp. 101-108 ◽  
Author(s):  
M. Krstic ◽  
Predrag Pesko ◽  
A.R. Pavlovic ◽  
D. Tomic ◽  
M. Micev ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Intestinal Tract ◽  
Muscularis Propria ◽  
Outer Margin ◽  
Stromal Tumor ◽  
Upper Endoscopy ◽  
Gastric Lesions ◽  
Muscularis Mucosae ◽  
Gastro Intestinal Tract

Background: Endoscopic ultrasonography(EUS) allows high-resolution demonstration of the entire gut wall. The aim of the study was to clarify the usefulness of the EUS in differential diagnosis of upper gastro-intestinal subepithelail lesions(SEL). Methods: From September 1998- March 2005, EUS was performed in 1600 patients. Among them, in 206pts (13%), this examination was carried out due to previous upper endoscopy, which revealed the suspicion to SEL or extraluminal compression. We studied the location, the size, echo pattern and originating layer of SEL. The results were compared with CT, angiography and operation with histology when possible. All EUS examinations were performed using Olympus GIF-130 videoecho-endoscope with 7,5/12MHz switch able radial probe. Results: EUS accuracy in separating intramural masses from extraluminal compression was 96 %( 44/46). Among 160 pts with true SEL, in 95(59, 3%), EUS revealed the existence of a stromal tumor arising from muscularis propria (92) or muscularis mucosae (3). The size of the tumor varied from 5-75mm; depth: 8- 40mm. 33 patients were operated on. In 14/16(87%), the EUS diagnosis of benign stromal tumor was confirmed on operation. In 18/19(95%), EUS correctly disclosed the malignant tumor. EUS accuracy in predicting malignancy was 91,5%(32/35). Findings suggestive for malignancy were: size 40mm; inhomogenicity with microcysts and irregular outer margin. In 12 pts, EUS revealed lypoma. Aberrant pancreas was correctly diagnosed in all 22pts. In 16 persons, EUS disclosed submucosal cysts: 6 of them were operated on and EUS diagnosis was confirmed in all. In 10 patients EUS visualized varices. The finding was confirmed on angiography. Conclusion: The EUS appears to be very effective in differential diagnosis of SEL in upper gastro-intestinal tract. Tumor size greater than 40mm, inhomomogenous echo pattern and irregular outer margin are very suggestive for malignancy.

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