Estimation of the Probability That Guillain-Barre Syndrome was Caused by the Swine Flu Vaccine: US Experience (1976–77)

1984 ◽  
Vol 24 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Richard L. Greenstreet
Keyword(s):  
United States ◽  
Puerto Rico ◽  
New Jersey ◽  
Statistical Method ◽  
The United States ◽  
Guillain Barre Syndrome ◽  
Swine Flu ◽  
Guillain Barré Syndrome ◽  
Flu Vaccine ◽  
Guillain Barré

A statistical method was presented for determining the probability that cases of Guillain-Barre syndrome (GBS) among residents of the United States and Puerto Rico who participated in the 1976–77 swine flu vaccine programme were due to the vaccine. It was determined that the vaccine (A/New Jersey) was the most likely cause of GBS if the onset was within five weeks after vaccination. From the sixth to the tenth week after vaccination, the association was unlikely. After the tenth week, the association between the vaccine and GBS was negative.

Guillain-Barré Syndrome Following (A/New Jersey/76) Influenza (Swine Flu) Vaccine: Epidemic or Artifact?

Neurology ◽  
1986 ◽  
pp. 249-254
Author(s):  
L. T. Kurland ◽  
W. C. Wiederholt ◽  
E. Beghi ◽  
J. W. Kirkpatrick ◽  
H. G. Potter ◽  
...  
Keyword(s):  
New Jersey ◽  
Guillain Barre Syndrome ◽  
Swine Flu ◽  
Guillain Barré Syndrome ◽  
Flu Vaccine ◽  
Guillain Barré

scholarly journals Estimation of the Incidence of Guillain-Barré Syndrome During Pregnancy in the United States

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Tanya R Myers ◽  
Natalie L McCarthy ◽  
Lakshmi Panagiotakopoulos ◽  
Saad B Omer
Keyword(s):  
United States ◽  
Adverse Event ◽  
Confidence Interval ◽  
The United States ◽  
Guillain Barre Syndrome ◽  
Rare Occurrence ◽  
Guillain Barré Syndrome ◽  
Safety Assessments ◽  
Few Data ◽  
Guillain Barré

Abstract Guillain-Barré syndrome (GBS) is an adverse event of interest after vaccination, yet few data are available for background rates during pregnancy. We confirmed 2 cases of incident GBS and estimated an incidence of 2.8 confirmed GBS cases per million person-years (95% confidence interval, 0.5–9.3), indicating rare occurrence. Our findings will help inform safety assessments of Zika vaccines in pregnant populations.

Arthritis, Guillain-Barré Syndrome, and Other Sequelae of Campylobacter jejuni Enteritis†

1995 ◽  
Vol 58 (10) ◽  
pp. 1153-1170 ◽  
Author(s):  
JAMES L. SMITH
Keyword(s):  
United States ◽  
Campylobacter Jejuni ◽  
Circulatory System ◽  
Developed Countries ◽  
The United States ◽  
Guillain Barre Syndrome ◽  
Food Sources ◽  
Fisher Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The most frequently identified cause of gastroenteritis in developed countries is Campylobacter jejuni. In the United States, dairy products are the food sources commonly associated with outbreaks; however, most cases of C. jejuni gastroenteritis are sporadic, with poultry as the major source. Diarrhea, malaise, fever, and abdominal pain are the usual symptoms of C. jejuni enteritis. Lasting only a few days, the illness is generally self-limiting; however, some cases may be more severe. Although several virulence factors have been identified in C. jejuni, their role in disease is currently unclear. C. jejuni has been linked to the acquisition of certain forms of sterile arthritides such as reactive arthritis and Reiter's syndrome and to acute generalized paralytic diseases such as Guillain-Barré syndrome, Miller-Fisher syndrome, and Chinese paralytic syndrome. In addition, C. jejuni may induce diseases affecting the nervous system, circulatory system, and various organs, particularly in immunocompromised individuals. Illnesses associated with C. jejuni have been estimated to cost the citizens of the United States several billion dollars annually.

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