The Effect of Stanozolol on the Fibrinolytic Enzyme System in Normal Subjects

1981 ◽  
Vol 26 (1_suppl) ◽  
pp. S59-S63 ◽  
Author(s):  
F. E. Preston
Keyword(s):  
Side Effects ◽  
Blood Coagulation ◽  
Enzyme System ◽  
Normal Subjects ◽  
Fibrinolytic Enzyme ◽  
Fibrinolytic System ◽  
Significant Stimulation ◽  
Volunteer Study ◽  
Coagulation And Fibrinolysis ◽  
Stimulation Of

In a volunteer study stanozolol was given in a dosage of 5mg twice per day for six weeks. A variety of parameters in blood coagulation and fibrinolysis were measured. Significant stimulation of the fibrinolytic system was found in seven days and this was associated with a significant fall in the levels of fibrinogen and alpha 2-macroglobulin. No major side effects were observed.

scholarly journals Effect of gaboon viper (Bitis gabonica) venom on blood coagulation, platelets, and the fibrinolytic enzyme system

1969 ◽  
Vol 22 (3) ◽  
pp. 312-316 ◽  
Author(s):  
C. D. Forbes ◽  
A. G. G. Turpie ◽  
J. C. Ferguson ◽  
G. P. McNicol ◽  
A. S. Douglas
Keyword(s):  
Blood Coagulation ◽  
Enzyme System ◽  
Fibrinolytic Enzyme

scholarly journals Blood coagulation and plasma fibrinolytic enzyme system pathophysiology in stroke.

Stroke ◽  
1976 ◽  
Vol 7 (4) ◽  
pp. 337-348 ◽  
Author(s):  
A P Fletcher ◽  
N Alkjaersig ◽  
A Davies ◽  
M Lewis ◽  
J Brooks ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Enzyme System ◽  
Fibrinolytic Enzyme

Comparison of In Vivo Effects on Components of the Canine Fibrinolytic Enzyme System of AMCHA Fed at Varying Dose Levels

1968 ◽  
Vol 20 (03/04) ◽  
pp. 574-582
Author(s):  
Evelyn Celander ◽  
D. R Celander
Keyword(s):  
Carboxylic Acid ◽  
Drug Administration ◽  
Enzyme System ◽  
Fibrinolytic Enzyme ◽  
Fibrinolytic System ◽  
Veronal Buffer ◽  
Canine Plasma ◽  
In Vivo Effects ◽  
Dose Levels

SummaryDogs were fed varying levels of trans-AMCHA (trans-4-aminomethyl-cyclohexane-1-carboxylic acid), a known inhibitor of the fibrinolytic enzyme system. Evidence that dialysis against citrate-veronal buffer in the cold for 24 hrs effectively removes AMCHA from plasma is presented. Determinations of antiactivator, antifibrinolysin, and proactivator were carried out on both dialyzed and undialyzed samples. At 55 mg/kg, a moderate immediate decrease in urokinase excretion occurred which was maintained throughout the time of drug administration. At higher levels, increases in antiactivator and decreases in proactivator and euglobulin lytic activity occurred, the extent of which could be roughly correlated with the amount of drug administered. No changes in either fibrinogen or antifibrinolysin were seen. An assay for the antiurokinase activity in canine plasma is described. The results are discussed in terms of the possible function of the fibrinolytic system as revealed by administration of inhibitors.

The Influence of Fats on Blood Coagulation and Fibrinolysis

1968 ◽  
Vol 19 (01/02) ◽  
pp. 267-278 ◽  
Author(s):  
O. J. A Th. Meuwissen ◽  
H Ch. Hart ◽  
M. S. E van Hemel-Rupert
Keyword(s):  
Blood Coagulation ◽  
Fibrinolytic Activity ◽  
Platelet Rich Plasma ◽  
Normal Subjects ◽  
High Fat ◽  
Saturated Fats ◽  
Recalcification Time ◽  
Fat Meal ◽  
Coagulation And Fibrinolysis

SummaryA review of experiments described in the literature discloses a lack of agreement about the influence of nutritional fats on blood coagulation and fibrinolysis. The numerous pertinent studies yielded contradictory results even if identical techniques were used.In our investigation, 17 normal subjects were given a breakfast containing 57 g saturated fats and one containing 54 g unsaturated fats. Before and 3 hrs after ingestion of the high-fat meal, blood was collected for determination of blood coagulation and fibrinolysis. There was no demonstrable difference between the two blood samples in terms of recalcification time of platelet-rich plasma in siliconized glass, euglobulin activity, fibrinolytic activity measured by lysis of plasminogen-poor and plasminogen-rich standard clots labelled with I131-fibrinogen, “activated fibrinolysis” (measuring the antiplasmin concentration) and the susceptibility to fibrinolysis of fibrin clots prepared in a standardized manner from fasting and hyperlipaemic plasma samples.In 6 normal subjects the experiments were expanded to encompass breakfasts with 118 saturated and 117 g unsaturated fats. After these high-fat meals, too, there was no demonstrable difference in recalcification time and in the various parameters of fibrinolysis.In order to establish whether atherosclerotic patients would show a different reaction to high-fat meals, the experiments were carried out also in 17 patients suffering from severe generalized atherosclerosis. These patients were given a low-fat breakfast, one with 57 g saturated fats and one with 54 g unsaturated fats. In this group, too, there were no demonstrable differences between the preprandial and postprandial data on blood coagulation and various parameters of fibrinolysis.

Activation of the Fibrinolytic Enzyme System in Laboratory Animals and in Man

1971 ◽  
Vol 25 (03) ◽  
pp. 499-506 ◽  
Author(s):  
A. J Baillie ◽  
A. K Sim
Keyword(s):  
Species Differences ◽  
Enzyme System ◽  
Fibrinolytic Enzyme ◽  
Fibrinolytic System ◽  
Laboratory Animals ◽  
Human Enzyme

SummaryThe activation characteristics of the fibrinolytic system of several species have been evaluated in vitro and compared with the human enzyme system. The cat, dog and baboon would appear to be the most suitable species for further study of fibrinolytic activation. The present findings have been found to parallel the species differences in platelet behaviour which have been reported separately from this laboratory.

The Blood Coagulation and Fibrinolytic Enzyme Systems in Healthy Adult Africans and Europeans — A Comparative Study

1973 ◽  
Vol 18 (3) ◽  
pp. 93-97 ◽  
Author(s):  
R. D. Barr ◽  
N. Ouna ◽  
A. G. Kendall
Keyword(s):  
Comparative Study ◽  
Vascular Disease ◽  
Blood Coagulation ◽  
Fibrinolytic Activity ◽  
Healthy Adult ◽  
Fibrinolytic Enzyme ◽  
Hypercoagulable State ◽  
Enzyme Systems ◽  
Coagulation And Fibrinolysis

In a comparative study of blood coagulation and fibrinolysis in healthy adult East Africans and Europeans, the Europeans were found to have some evidence of a relatively hypercoagulable state, and the European male had significantly reduced fibrinolytic activity and potential when compared to the African male. A parallel is drawn with the known prevalence of atheroma and thrombo-embolic disease in these populations and the suggestion made that the greater fibrinolytic activity of the African, perhaps resulting from a radically different diet, may account in large part for his relative freedom from atheromatous vascular disease.

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck
Keyword(s):  
Blood Coagulation ◽  
Antithrombin Iii ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Excessive Bleeding ◽  
Oestrone Sulphate ◽  
Menopausal Women ◽  
History Of ◽  
Coagulation And Fibrinolysis

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

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