Total Body Potassium in Patients Receiving Chlorthalidone and Metoprolol for Hypertension

1983 ◽  
Vol 28 (2) ◽  
pp. 172-175 ◽  
Author(s):  
J. M. B. Gray ◽  
D. H. Lawson ◽  
K. Boddy ◽  
W. East
Keyword(s):  
Blood Cell ◽  
Plasma Potassium ◽  
Fixed Dose ◽  
Average Period ◽  
Total Body Potassium ◽  
Total Blood ◽  
Hypertensive Patients ◽  
Dose Combination ◽  
Β Blocker ◽  
Total Body

Measurements of potassium status were reviewed in 23 hypertensive patients receiving metoprolol either alone or in combination with chlorthalidone or chlorthalidone plus potassium over an average period of nine months. There was no statistically significant change in plasma potassium, total blood cell or total body groups developed hypokalaemia (serum potassium <3.0mmol/l) in the absence of significant falls in total blood cell or total body potassium. Thus the use of chlorthalidone plus potassium did not provide adequate prophylaxis against hypokalaemia even in metoprolol recipients. The study confirms that monitoring parameters of potassium handling is still necessary in β-blocker recipients who also receive diuretics alone or in a fixed-dose combination with potassium.

Relation of Arterial Pressure with Body Sodium, Body Potassium and Plasma Potassium in Essential Hypertension

1982 ◽  
Vol 63 (3) ◽  
pp. 257-270 ◽  
Author(s):  
C. Beretta-Piccoli ◽  
D. L. Davies ◽  
K. Boddy ◽  
J. J. Brown ◽  
A. M. M. Cumming ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Pressure ◽  
Potassium Concentration ◽  
Plasma Potassium ◽  
Normal Subjects ◽  
Total Body Potassium ◽  
Hypertensive Patients ◽  
Body Sodium ◽  
Low Renin Hypertension ◽  
Total Body

1. Exchangeable sodium (NaE), plasma electrolytes and arterial pressure were measured in 121 normal subjects and 91 patients with untreated essential hypertension (diastolic >100 mmHg), 21 of whom had low-renin hypertension. Plasma concentrations of renin, angiotensin II and aldosterone were measured in all hypertensive patients, total body sodium, total body potassium and exchangeable potassium (KE) in some patients. 2. Mean NaE was not different in normal and hypertensive subjects provided the two groups were matched for leanness index. In the subgroup of young hypertensive patients aged 35 years or less mean NaE was below normal. NaE was not related to arterial pressure in normal subjects but in hypertensive patients there were positive and significant correlations of arterial pressure with NaE and with total body sodium. 3. NaE and total body sodium increased with age in hypertensive but not in normal subjects. Partial regression analysis suggested that the correlation of NaE with arterial pressure was not explained by an influence of age. 4. Mean NaE was not increased and mean KE was not decreased in patients with low-renin hypertension. 5. Plasma potassium concentration, KE and total body potassium correlated inversely and significantly with blood pressure in hypertensive patients. These correlations were more marked in young than in old patients. 6. Multiple regression analysis showed that the combination of NaE and plasma potassium concentration ‘explained’ more of the variation of systolic blood pressure in hypertensive patients than it did in normal subjects. Plasma potassium concentration ‘explained’ more of the variation in young hypertensives and NaE ‘explained’ more in older patients. 7. Our findings suggest that changes of plasma and body potassium are important in the earlier stages of essential hypertension and that changes of body sodium become important later.

Relation of Arterial Pressure with Exchangeable and Total Body Sodium and with Plasma Exchangeable and Total Body Potassium in Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 81s-84s ◽  
Author(s):  
C. Beretta-Piccoli ◽  
D. L. Davies ◽  
K. Boddy ◽  
J. J. Brown ◽  
A. M. M. Cumming ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Potassium Concentration ◽  
Young Patients ◽  
Plasma Potassium ◽  
Normal Subjects ◽  
Exchangeable Sodium ◽  
Total Body Potassium ◽  
Hypertensive Patients ◽  
Body Sodium ◽  
Total Body

1. Arterial pressure, plasma electrolytes and exchangeable sodium were measured in 91 patients with essential hypertension and in 121 normal control subjects. Total body sodium, exchangeable potassium and total body potassium were also measured in some of the hypertensive patients. 2. Mean plasma sodium concentration was slightly but significantly lower in the hypertensive patients as a group, but mean values for other electrolyte measurements were close to normal or predicted normal. 3. Exchangeable sodium was not related to arterial pressure in normal subjects but in hypertensive patients exchangeable sodium correlated significantly with systolic and diastolic pressures. These correlations were significant with two methods of expressing exchangeable sodium, in the whole group of patients, in men and in older patients. Exchangeable sodium was not significantly related to arterial pressure in young patients. 4. Total body sodium also correlated significantly with systolic and diastolic pressures in hypertensive patients. 5. Exchangeable sodium was significantly related to age in hypertensive patients but not in normal subjects. Mean exchangeable sodium was significantly lower than normal in young patients. 6. Plasma potassium concentration was not related to arterial pressure in normal subjects but in essential hypertensive patients plasma potassium concentration, exchangeable potassium and total body potassium correlated negatively with systolic and diastolic pressures. These correlations were also significant in young, but not in old patients.

scholarly journals An observational comparative study of different doses of azilsartan and with chlorthalidone combination in moderate hypertension

2019 ◽  
Vol 8 (2) ◽  
pp. 259
Author(s):  
Tamoghna Maiti ◽  
Sonai Mandal ◽  
Ratul Banerjee ◽  
Sourav Chakrabarty ◽  
Amrita Panda
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Antihypertensive Agents ◽  
Fixed Dose ◽  
High Dose ◽  
Hypertensive Patients ◽  
Medical College ◽  
Fda Approval ◽  
High Prevalence ◽  
Dose Combination

Background: High blood pressure (BP) is one of the significant non-communicable diseases that are of high prevalence in our country. Hypertension (HTN) is responsible cause of 57% of stroke and 24% of coronary heart disease deaths in India. Eight classes of medications are currently used in the treatment of hypertension. Azilsartan medoxomil is a newly added FDA approved drug to the ARB class of antihypertensive agents. azilsartan and chlorthalidone combination is also got the FDA approval. There is limited study in between these two groups regarding efficacy especially in rural Bengal.Methods: A prospective observational study was done in medicine OPD of Bankura Sammilani Medical College for twelve weeks with two groups that are azilsartan (80mg) and fixed dose combination of azilsartan (40mg) plus chlorthalidone (12.5mg) in the age group of 18 to 55years of moderate hypertensive patients. Change of heart rate was assessed as safety parameter.Results: It was found that both the group of drugs are very much effective in lowering blood pressure constantly in respect of both systolic and diastolic BP but azilsartan monotherapy in high dose reduce systolic blood pressure slightly high. Significant change of heart rate was not seen with both the groups.Conclusions: Both the group was effective as well as safe in hypertensive patients.

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