Syringomyelia after spinal anaesthesia: A case report

2021 ◽  
pp. 004947552110377
Author(s):  
Govind Madhaw ◽  
Divya M Radhakrishnan ◽  
Niraj Kumar
Keyword(s):  
Spinal Cord ◽  
Spinal Anaesthesia ◽  
Neurological Complications ◽  
Interesting Case ◽  
Dorsal Spinal Cord ◽  
Cord Injury ◽  
Lower Complication ◽  
Lower Complication Rate ◽  
Lumbar Spinal ◽  
Dorsal Spinal

Lumbar spinal or epidural anaesthesia has a lower complication rate compared to general anaesthesia. An occasional patient may develop spinal cord injury during the procedure and develop neurological complications. We report an interesting case of paraparesis due to dorsal spinal cord involvement and syrinx formation following spinal anaesthesia for abdominal surgery.

scholarly journals Dorsal spinal cord injury as a cause of recurrent asystole requiring permanent cardiac pacing

EP Europace ◽  
2011 ◽  
Vol 14 (1) ◽  
pp. 146-147 ◽  
Author(s):  
M. Peyrol ◽  
P. Sbragia ◽  
J. A. Trigano ◽  
F. Paganelli
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cardiac Pacing ◽  
Dorsal Spinal Cord ◽  
Cord Injury ◽  
Dorsal Spinal

scholarly journals Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

Pain ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 649-655 ◽  
Author(s):  
Amin Boroujerdi ◽  
Jun Zeng ◽  
Kelli Sharp ◽  
Donghyun Kim ◽  
Oswald Steward ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Calcium Channel ◽  
Dorsal Spinal Cord ◽  
Cord Injury ◽  
Dorsal Spinal

Acute Cervical Myelopathy from Hereditary Multiple Exostoses: Case Report

Neurosurgery ◽  
1989 ◽  
Vol 25 (3) ◽  
pp. 472-475 ◽  
Author(s):  
Dennis Y. Wen ◽  
Thomas A. Bergman ◽  
Stephen J. Haines
Keyword(s):  
Spinal Cord ◽  
Cervical Myelopathy ◽  
Neurological Complications ◽  
Cord Compression ◽  
Resonance Imaging ◽  
Dorsal Spinal Cord ◽  
Decompressive Laminectomy ◽  
Hereditary Multiple Exostoses ◽  
Multiple Exostoses ◽  
Dorsal Spinal

Abstract A case of hereditary multiple exostoses with acute cervical myelopathy, tetraplegia, and apnea is reported. Neurological complications as a result of osteochondromas in hereditary multiple exostoses are rare. The majority of osteochondromas in the cervical spine arise from the neural arch. Magnetic resonance imaging and computed tomography are invaluable in localizing the origin of the lesion and its relationship to the spinal cord. Decompressive laminectomy usually results in excellent functional recovery. Where significant dorsal spinal cord compression exists without neurological deficit, prophylactic decompression can be recommended.

scholarly journals Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

2019 ◽  
Author(s):  
Brendan Puls ◽  
Yan Ding ◽  
Fengyu Zhang ◽  
Mengjie Pan ◽  
Zhuofan Lei ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Cell Fate ◽  
High Efficiency ◽  
Reactive Astrocytes ◽  
Dorsal Spinal Cord ◽  
Spinal Cord Neurons ◽  
Cord Injury ◽  
Dorsal Spinal

AbstractSpinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology to regenerate neurons from endogenous glial cells by forced expression of neurogenic transcription factors. We have previously demonstrated successful astrocyte-to-neuron conversion in mouse brains with injury or Alzheimer’s disease by overexpressing a single neural transcription factor NeuroD1 via retroviruses. Here we demonstrate regeneration of dorsal spinal cord neurons from reactive astrocytes after SCI via adeno-associated virus (AAV), a more clinically relevant gene delivery system. We find that NeuroD1 converts reactive astrocytes into neurons in the dorsal horn of stab-injured spinal cord with high efficiency (∼95%). Interestingly, NeuroD1-converted neurons in the dorsal horn mostly acquire glutamatergic neuronal subtype, expressing spinal cord-specific markers such as Tlx3 but not brain-specific markers such as Tbr1, suggesting that the astrocytic lineage and local microenvironment affect the cell fate of conversion. Electrophysiological recordings show that the NeuroD1-converted neurons can functionally mature and integrate into local spinal cord circuitry by displaying repetitive action potentials and spontaneous synaptic responses. We further show that NeuroD1-mediated neuronal conversion can occur in the contusive SCI model, allowing future studies of evaluating this reprogramming technology for functional recovery after SCI. In conclusion, this study may suggest a paradigm shift for spinal cord repair using in vivo astrocyte-to-neuron conversion technology to generate functional neurons in the grey matter.

scholarly journals Below Level Central Pain Induced by Discrete Dorsal Spinal Cord Injury

2010 ◽  
Vol 27 (9) ◽  
pp. 1697-1707 ◽  
Author(s):  
Julie Wieseler ◽  
Amanda L. Ellis ◽  
Andrew McFadden ◽  
Kimberley Brown ◽  
Charlotte Starnes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Central Pain ◽  
Dorsal Spinal Cord ◽  
Cord Injury ◽  
Dorsal Spinal

Deactivation and reactivation of somatosensory cortex after dorsal spinal cord injury

Nature ◽  
1997 ◽  
Vol 386 (6624) ◽  
pp. 495-498 ◽  
Author(s):  
Neeraj Jain ◽  
Kenneth C. Catania ◽  
Jon H. Kaas
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Somatosensory Cortex ◽  
Dorsal Spinal Cord ◽  
Cord Injury ◽  
Dorsal Spinal

Idiopathic dorsal spinal cord herniation perforating the lamina: a case report and review of the literature

2021 ◽  
Author(s):  
Haruki Funao ◽  
Satoshi Nakamura ◽  
Kenshi Daimon ◽  
Norihiro Isogai ◽  
Yutaka Sasao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Review Of The Literature ◽  
Dorsal Spinal Cord ◽  
Spinal Cord Herniation ◽  
Dorsal Spinal

scholarly journals Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Marco Bonizzato ◽  
Nicholas D. James ◽  
Galyna Pidpruzhnykova ◽  
Natalia Pavlova ◽  
Polina Shkorbatova ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Stress Responses ◽  
Learning Algorithm ◽  
Lumbar Spinal Cord ◽  
Cord Injury ◽  
Potential Synergy ◽  
Lumbar Spinal ◽  
Deep Brain

AbstractA spinal cord injury usually spares some components of the locomotor circuitry. Deep brain stimulation (DBS) of the midbrain locomotor region and epidural electrical stimulation of the lumbar spinal cord (EES) are being used to tap into this spared circuitry to enable locomotion in humans with spinal cord injury. While appealing, the potential synergy between DBS and EES remains unknown. Here, we report the synergistic facilitation of locomotion when DBS is combined with EES in a rat model of severe contusion spinal cord injury leading to leg paralysis. However, this synergy requires high amplitudes of DBS, which triggers forced locomotion associated with stress responses. To suppress these undesired responses, we link DBS to the intention to walk, decoded from cortical activity using a robust, rapidly calibrated unsupervised learning algorithm. This contingency amplifies the supraspinal descending command while empowering the rats into volitional walking. However, the resulting improvements may not outweigh the complex technological framework necessary to establish viable therapeutic conditions.

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