Survival of Malnourished Head and Neck Cancer Patients Can Be Predicted by Human Leukocyte Antigen-DR Expression and Interleukin-6/Tumor Necrosis Factor-α Response of the Monocyte

2000 ◽  
Vol 24 (6) ◽  
pp. 329-336 ◽  
Author(s):  
Marian A. E. van Bokhorst-de van der Schueren ◽  
B. Mary E. von Blomberg-van der Flier ◽  
Dirk J. Kuik ◽  
Petra E. T. Scholten ◽  
Michiel P. C. Siroen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Patients ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Factor Α ◽  
Necrosis Factor

Influence of G308A polymorphism of tumor necrosis factor-α gene on inflammatory markers in postsurgical head and neck cancer patients with early enteral nutrition

Nutrition ◽  
2007 ◽  
Vol 23 (7-8) ◽  
pp. 529-532 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Manue Gonzalez Sagrado ◽  
Luis Angel Vallejo ◽  
Luis María Gil Carcedo ◽  
Olatz Izaola ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Necrosis Factor ◽  
Enteral Nutrition ◽  
Cancer Patients ◽  
Inflammatory Markers ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Early Enteral Nutrition ◽  
Factor Α ◽  
Necrosis Factor

The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients

2011 ◽  
Vol 26 (3) ◽  
pp. 275-282 ◽  
Author(s):  
Sang Mi Kwak ◽  
Youn Seon Choi ◽  
Ho Min Yoon ◽  
Dae Gyun Kim ◽  
Seung Hun Song ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Cancer Patients ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Terminally Ill ◽  
Terminally Ill Cancer Patients ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Monocytes from HTLV-1–infected patients are unable to fully mature into dendritic cells

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 489-499 ◽  
Author(s):  
Clarissa Rodrigues Nascimento ◽  
Marco Antonio Lima ◽  
Maria José de Andrada Serpa ◽  
Otávio Espindola ◽  
Ana Claudia Celestino Leite ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Necrosis Factor ◽  
Human Leukocyte Antigen ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Spastic Paraparesis ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Factor Α ◽  
Necrosis Factor

AbstractHuman T-cell lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia and HTLV-1–associated myelopathy/tropical spastic paraparesis. HTLV-1–associated myelopathy/tropical spastic paraparesis is a chronic inflammatory disease characterized by loss of motor movement in response to spinal marrow cell destruction by T lymphocytes. To perform their cellular function, T cells need to be activated by antigen-presenting cells, such as dendritic cells (DCs). The aim of this work was to analyze DC differentiation and activation from monocytes of HTLV-1–infected individuals. We demonstrated that monocytes from HTLV-1–infected patients who had been stimulated to differentiate had an impaired loss of CD14 expression, expressed low levels of CD1a, and maintained secretion of tumor necrosis factor-α compared with monocytes from noninfected donors. We further evaluated DC activation by tumor necrosis factor-α. We observed that in response to activation, DCs that were derived from noninfected donors had an increase in the percentage of CD83+, CD86+, and human leukocyte antigen-DR+ cells, whereas in DCs derived from HTLV-1–infected patients, the percentage of CD83+, CD86+, and human leukocyte antigen-DR+ cells remained similar to that of nonactivated cells. Moreover, these cells had an impaired capacity to stimulate allogeneic T lymphocytes. We demonstrated that DC maturation was altered in HTLV-1–infected patients, which could contribute to the development of HTLV-1–associated diseases.

scholarly journals FRI0374 PLASMA LEVELS OF 14-3-3 PROTEIN, S100A8/S100A9-PROTEIN, INTERLEUKIN-6, INTERLEUKIN-18, INTERLEUKIN-4, INTERLEUKIN-17, INTERLEUKIN-1Β AND TUMOR NECROSIS FACTOR-Α IN CHRONIC NON-BACTERIAL OSTEOMYEILITIS AND NON-SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 784.3-784
Author(s):  
M. Kostik ◽  
M. Makhova ◽  
D. Kozlova ◽  
D. Vasilyev ◽  
L. Sorokina ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Immune Mediated ◽  
Factor Α ◽  
Necrosis Factor

Background:Chronic non-bacterial osteomyelitis (CNO) is an immune-mediated disease associated with cytokine dysbalance.Objectives:The aim of our study was to evaluate the cytokines levels in CNO and compare to juvenile idiopathic arthritis (JIA) – disease with immune-mediated mechanism.Methods:The diagnosis of CNO made with criteria, proposed by Jansson (2007, 2009), after the exclusion of other causes of bone disease [1]. We included 42 patients with NBO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA). We evaluated plasma levels of 14-3-3 protein, S100A8/S100A9-protein, interleukine-6 (IL-6), interleukine-18 (IL-18), interleukine-4 (IL-4), interleukine-17 (IL-17), interleukine-1β (IL-1 β) and tumor necrosis factor-α (TNFα) in 2 groups by the ELISA. Statistical analysis was carried out with Statistica 10.0 software. We utilized descriptive statistics (Me; IQR), Mann-Whitney tests.Results:We have found differences in the proinflammatory biomarkers between CNO, JIA. Patients with NBO had lower levels of studied cytokines, exclude14-3-3-protein, S100A8/S100A9 and interleukin-6 compare to JIA patients (table 1).Table 1.Comparison the cytokine levels between CNO, JIA NParameterNBO (n=42)JIA (n=28)pHemoglobin, g/l112 (104; 124)120 (114.5; 126.0)0.02WBC x 109/l7.9 (7.0; 10.5)8.0 (6.7; 10.0)0.86PLT x 109/l347 (259; 408)336.5 (274.0; 390.5)0.98ESR. mm/h25.0 (9.0; 46.0)8.5 (2.5; 13.0)0.013CRP, mg/l6.1 (0.6; 2.4)1.8 (0.4; 11.9)0.02714-3-3, ng/ml21.4 (18.5; 27.1)19.9 (18.0; 27.8)0.77S100A8/S100A9, ng/ml5.9 (5.2; 6.5)5.9 (5.0; 6.2)0.76IL-6, ng/ml126,2 (112.8; 137.5)132.4 (117.4; 142.9)0.16IL-18, ng/ml270.1 (200.1; 316.1)388.3 (373.9; 405.1)0.0000001IL-4, ng/ml15.3 (11.5; 18.2)18.7 (16.2; 20.2)0.003IL-17, ng/ml83.1 (71.1; 97.3)99.2 (87.3; 115.8)0.003IL-1b, ng/ml47.4 (42.0; 51.3)70.8 (65.3; 73.6)0.0000001TNFa, ng/ml19.4 (17.8; 21.3)23.1 (20.2; 25.9)0.0006Conclusion:Patients with CNO had less proinflammatory activity then JIA patients, besides IL-6 and S100A8/S100A9. Further investigations required for finding new more precise biomarkers and finding possible molecular targets for treatment.This work supported by the Russian Foundation for Basic Research (grant № 18-515-57001)References:[1]Jansson AF, et al. Clinical score for nonbacterial osteitis in children and adults. Arthritis Rheum. 2009;60(4):1152-9.Disclosure of Interests:None declared

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