Developmental psychopathology: Pathways to the future

2006 ◽  
Vol 30 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Ann S. Masten
Keyword(s):  
Developmental Psychopathology ◽  
Special Section ◽  
Theory And Practice ◽  
Environment Interaction ◽  
Developmental Systems ◽  
Future Directions ◽  
New Era ◽  
Integrative Framework ◽  
Gene Environment Interaction ◽  
Gene Environment

This article highlights the defining principles, progress and future directions in developmental psychopathology in relation to this special section. Six fundamental principles of developmental psychopathology are identified and the pervasive impact of this integrative framework on research, theory, and practice in behavioral health fields over the past three decades is described. This special section reflects the increasing influence of developmental systems theory, the growing focus on change, intensifying interest in translational research, and the increasingly complex and differentiated nature of research on pathways toward and away from psychopathology. A new era in developmental psychopathology is dawning, with exciting frontiers in brain development and plasticity, gene-environment interaction, resilience and recovery, multilevel dynamics, interdisciplinary research and training, and methodologies for assessing and analyzing change over time within and across individual systems and their contexts.

Gene–environment interactions in humans across multiple units of analyses

2019 ◽  
pp. 18-31
Author(s):  
Suzanne Vrshek-Schallhorn ◽  
Bradley M Avery ◽  
Vaibhav Sapuram
Keyword(s):  
Psychological Functioning ◽  
Theoretical Models ◽  
Mental Illnesses ◽  
Environment Interaction ◽  
Future Directions ◽  
Gene Environment Interaction ◽  
Risk Environments ◽  
P Gene ◽  
Gene Environment ◽  
Multiple Units

Gene–environment interaction (G×E) research in humans seeks to answer how specific genetic variation contributes to marked individual differences in responding to life experiences, primarily in regard to psychological functioning. In this chapter, we highlight theoretical models underlying G×E research, aspects of its history and controversies, the current state of G×E knowledge, and emerging and future directions for G×E research. Throughout this discussion, we show how this work has emerged across multiple units or levels of analyses, ranging from those closer to the biological functioning of the genes involved, such as neural activity in functional imaging, to more distal outcomes such as diagnoses of psychopathology. Important future directions for G×E research are transitioning from single variant to multiple variant approaches, and more carefully conceptualizing and measuring risk environments while also boosting sample sizes. Ultimately, by attending to these issues, G×E research can not only contribute to early detection of individuals with risky genetic and environmental profiles, but can also aid in revealing etiological pathways, thereby elucidating novel treatment approaches to mental illnesses.

scholarly journals Gene–environment correlation in developmental psychopathology

2013 ◽  
Vol 25 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ariel Knafo ◽  
Sara R. Jaffee
Keyword(s):  
Child Psychopathology ◽  
Developmental Psychopathology ◽  
Normal Development ◽  
Special Section ◽  
Future Directions ◽  
The Past ◽  
Gene Environment ◽  
Joint Products ◽  
Methodological Approaches ◽  
Important Form

AbstractModern research acknowledges that psychopathology and individual differences in normal development are the joint products of both biological and social influences. Although there have been numerous publications on Gene × Environment interactions in the past decade, gene–environment correlation is another important form of gene–environment interplay that has received less attention. This Special Section demonstrates, using a range of methodological approaches, the importance of gene–environment correlation in developmental psychopathology. Several types of gene–environment correlation are described, including passive, evocative, and active. Other studies highlight the potential for gene–environment correlation to obscure associations between risk exposures and child psychopathology. Future directions for gene–environment correlation research are discussed.

Gene-Environment Interaction in the Determination of Levels of Haemostatic Variables Involved in Thrombosis and Fibrinolysis

1997 ◽  
Vol 78 (01) ◽  
pp. 457-461 ◽  
Author(s):  
S E Humphries ◽  
A Panahloo ◽  
H E Montgomery ◽  
F Green ◽  
J Yudkin
Keyword(s):  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment
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