scholarly journals Toxicologic Pathology Forum*: Opinion on Considerations for the Use of Whole Slide Images in GLP Pathology Peer Review

2019 ◽  
Vol 47 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Alys Bradley ◽  
Matt Jacobsen
Keyword(s):  
Peer Review ◽  
Glass Slide ◽  
Whole Slide Imaging ◽  
Laboratory Practice ◽  
Advantages And Disadvantages ◽  
Primary Means ◽  
Good Laboratory ◽  
High Level ◽  
Regulatory Acceptance ◽  
Whole Slide Images

Whole slide imaging (WSI) technology has advanced to a point where it has replaced the glass slide as the primary means of pathology evaluation within many areas of medical pathology. The deployment of WSI in the field of toxicologic pathology has been delayed by a lack of clarity around the degree of validation required for its use on Good Laboratory Practice (GLP) studies. The current opinion piece attempts to provide a high-level overview of WSI technology to include basic methodology, advantages and disadvantages over a conventional microscope, validation status of WSI scanners, and perceived concerns over regulatory acceptance for the use of WSI for (GLP) peer review in the field of toxicologic pathology. Observations are based on the extensive use by AstraZeneca of WSI for the peer review of non-GLP studies conducted at Charles River facilities and represent the experiences of the authors. [Box: see text]

scholarly journals Toxicologic Pathology Forum*: Opinion on Integrating Innovative Digital Pathology Tools in the Regulatory Framework

2019 ◽  
Vol 47 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Béatrice E. Gauthier ◽  
Frédéric Gervais ◽  
Gregory Hamm ◽  
Donal O’Shea ◽  
Alain Piton ◽  
...  
Keyword(s):  
Digital Pathology ◽  
Whole Slide Imaging ◽  
Software Validation ◽  
French Society ◽  
Laboratory Practice ◽  
Qualitative And Quantitative ◽  
Annual Congress ◽  
Good Laboratory ◽  
Practice Framework ◽  
Opinion Article

Digital pathology is defined as the ability to examine digitized microscopic slides and to generate qualitative and quantitative data. The field of digital pathology is rapidly evolving and has the potential to revolutionize toxicologic pathology. Techniques such as automated 2-D image analysis, whole slide imaging, and telepathology are already considered “mature” technologies and have been used for decades in exploratory studies; however, many organizations are reluctant to use digital pathology in regulatory toxicology studies. Innovative technologies using digitized slides including high-content imaging modalities and artificial intelligence are still under development but are increasingly used in toxicologic pathology. While software validation requirements are already described, clear guidance for application of these rules to the digital pathology field are few and the acceptance of these technologies by regulatory authorities remains necessary for successful adoption of digital pathology into the mainstream of toxicologic pathology. This topic was discussed during a roundtable at the 2018 Annual Congress of the French Society of Toxicologic Pathology. This opinion article summarizes the discussion regarding the current questions and challenges on the integration of innovative digital pathology tools within a good laboratory practice framework and is meant to stimulate further discussion among the toxicologic pathology community. [Box: see text]

The Application, Challenges, and Advancement Toward Regulatory Acceptance of Digital Toxicologic Pathology: Results of the 7th ESTP International Expert Workshop (September 20-21, 2019)

2020 ◽  
pp. 019262332097584
Author(s):  
Vanessa L. Schumacher ◽  
Famke Aeffner ◽  
Erio Barale-Thomas ◽  
Catherine Botteron ◽  
Jonathan Carter ◽  
...  
Keyword(s):  
European Society ◽  
International Workshop ◽  
Digital Pathology ◽  
Remote Access ◽  
Whole Slide Imaging ◽  
International Expert ◽  
Digital Slide ◽  
Regulatory Acceptance ◽  
Expert Workshop ◽  
Whole Slide Images

With advancements in whole slide imaging technology and improved understanding of the features of pathologist workstations required for digital slide evaluation, many institutions are investigating broad digital pathology adoption. The benefits of digital pathology evaluation include remote access to study or diagnostic case materials and integration of analysis and reporting tools. Diagnosis based on whole slide images is established in human medical pathology, and the use of digital pathology in toxicologic pathology is increasing. However, there has not been broad adoption in toxicologic pathology, particularly in the context of regulatory studies, due to lack of precedence. To address this topic, as well as practical aspects, the European Society of Toxicologic Pathology coordinated an expert international workshop to assess current applications and challenges and outline a set of minimal requirements needed to gain future regulatory acceptance for the use of digital toxicologic pathology workflows in research and development, so that toxicologic pathologists can benefit from digital slide technology.

scholarly journals Whole-Slide Imaging Digital Pathology as a Platform for Teleconsultation: A Pilot Study Using Paired Subspecialist Correlations

2009 ◽  
Vol 133 (12) ◽  
pp. 1949-1953 ◽  
Author(s):  
David C. Wilbur ◽  
Kalil Madi ◽  
Robert B. Colvin ◽  
Lyn M. Duncan ◽  
William C. Faquin ◽  
...  
Keyword(s):  
Digital Pathology ◽  
Glass Slide ◽  
Whole Slide Imaging ◽  
Improve Performance ◽  
Standard Glass ◽  
Digital Format ◽  
Glass Slides ◽  
Technical Issues ◽  
Fine Resolution ◽  
Whole Slide Images

Abstract Context.—Whole-slide imaging technology offers promise for rapid, Internet-based telepathology consultations between institutions. Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized. Objective.—To determine whether interpretation of whole-slide images differed from glass-slide interpretation in difficult surgical pathology cases. Design.—Diagnostically challenging pathology slides from a variety of anatomic sites from an outside laboratory were scanned into whole digital format. Digital and glass slides were independently diagnosed by 2 subspecialty pathologists. Reference, digital, and glass-slide interpretations were compared. Operator comments on technical issues were gathered. Results.—Fifty-three case pairs were analyzed. There was agreement among digital, glass, and reference diagnoses in 45 cases (85%) and between digital and glass diagnoses in 48 (91%) cases. There were 5 digital cases (9%) discordant with both reference and glass diagnoses. Further review of each of these cases indicated an incorrect digital whole-slide interpretation. Neoplastic cases showed better correlation (93%) than did cases of nonneoplastic disease (88%). Comments on discordant cases related to digital whole technology focused on issues such as fine resolution and navigating ability at high magnification. Conclusions.—Overall concordance between digital whole-slide and standard glass-slide interpretations was good at 91%. Adjustments in technology, case selection, and technology familiarization should improve performance, making digital whole-slide review feasible for broader telepathology subspecialty consultation applications.

scholarly journals A survey: which features are required for dynamic visual simultaneous localization and mapping?

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Zewen Xu ◽  
Zheng Rong ◽  
Yihong Wu
Keyword(s):  
Simultaneous Localization And Mapping ◽  
Dynamic Environments ◽  
Visual Features ◽  
Advantages And Disadvantages ◽  
Intelligent Robots ◽  
Localization And Mapping ◽  
High Level ◽  
Static World ◽  
Robotic Applications ◽  
Significant Attention

AbstractIn recent years, simultaneous localization and mapping in dynamic environments (dynamic SLAM) has attracted significant attention from both academia and industry. Some pioneering work on this technique has expanded the potential of robotic applications. Compared to standard SLAM under the static world assumption, dynamic SLAM divides features into static and dynamic categories and leverages each type of feature properly. Therefore, dynamic SLAM can provide more robust localization for intelligent robots that operate in complex dynamic environments. Additionally, to meet the demands of some high-level tasks, dynamic SLAM can be integrated with multiple object tracking. This article presents a survey on dynamic SLAM from the perspective of feature choices. A discussion of the advantages and disadvantages of different visual features is provided in this article.

scholarly journals SARS-CoV-2 serologic tests: do not forget the good laboratory practice

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Elena Aloisio ◽  
Felicia Stefania Falvella ◽  
Assunta Carnevale ◽  
Mauro Panteghini
Keyword(s):  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Serologic Tests ◽  
Good Laboratory

Good laboratory practice-compliant bio-efficacy testing of repellent products against Aedes aegypti

2021 ◽  
Author(s):  
R. Rosilawati ◽  
A. Ruziyatul Aznieda ◽  
A. Roziah ◽  
N. Ab Hamid ◽  
C. H. Teh ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Good Laboratory Practice ◽  
Laboratory Practice ◽  
Good Laboratory
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