scholarly journals Case Report: Canine Strain– and Study Condition–Dependent Formation of Renaut Bodies in Sciatic Nerves of Beagle Dogs

2019 ◽  
Vol 48 (1) ◽  
pp. 244-252 ◽  
Author(s):  
Klaus Weber ◽  
Felix Weber ◽  
Monica Longo ◽  
Yoshimasa Okazaki ◽  
Nils Warfving ◽  
...  
Keyword(s):  
Case Report ◽  
Beagle Dogs ◽  
Test Article ◽  
Moderate Number ◽  
Infusion Study ◽  
Renaut Bodies ◽  
Catheter Implantation ◽  
Sciatic Nerves ◽  
Intrathecal Infusion ◽  
Lateral Recumbency

Two beagle dog strains were used in a 14-day intrathecal infusion study for a small molecule test article. A moderate number of Renaut bodies (RBs) were observed in the sciatic nerves of control and test article–treated adult animals as early as 1 day after test article infusion (ie, 5 days after catheter implantation in the lumbar cistern). In most cases, the sciatic nerve was affected unilaterally, apparently in association with extended lateral recumbency on one side. The lighter beagle strain (Marshall), and especially the females (which weighed less than age-matched Marshall males), developed more RBs. In contrast, neither females nor males of the larger strain (Harlan) developed any nerve lesions. These data support the hypothesis that RBs develop following mechanical stress to sciatic nerves, suggest that this change may develop fairly quickly following an insult, and demonstrate that different dog strains exhibit strain-specific nerve changes.

Use Of External Intrathecal Infusion Pumps In The Management Of Septic Complications: A Case Report

2015 ◽  
Vol 15 (4) ◽  
pp. 293-296
Author(s):  
Riccardo Marvulli ◽  
Pierpaolo Chiumarulo ◽  
Mattia Nisi ◽  
Laura Barulli ◽  
Gianfranco Megna ◽  
...  
Keyword(s):  
Case Report ◽  
Infusion Pumps ◽  
Septic Complications ◽  
Intrathecal Infusion

Practice of yoga may cause damage of both sciatic nerves: a case report

2012 ◽  
Vol 34 (3) ◽  
pp. 393-396 ◽  
Author(s):  
Patrizia Dacci ◽  
Stefano Amadio ◽  
Simonetta Gerevini ◽  
Lucia Moiola ◽  
Ubaldo Del Carro ◽  
...  
Keyword(s):  
Case Report ◽  
Sciatic Nerves

Unusual Incidence and Location of Renaut Bodies in Beagle Dogs in a Nonclinical Study

2020 ◽  
Vol 48 (3) ◽  
pp. 524-528
Author(s):  
Sophie Nelissen ◽  
Joost Lensen ◽  
Erio Barale-Thomas
Keyword(s):  
Sciatic Nerve ◽  
Adrenal Gland ◽  
Toxicity Study ◽  
Autonomic Nerves ◽  
Beagle Dogs ◽  
Unusual Location ◽  
Renaut Bodies ◽  
Nonclinical Study

We identified the presence of Renaut bodies in an unusual location in Beagle dogs on a 3-month nonclinical toxicity study. These peculiar structures are commonly reported as a background finding in the sciatic nerve of dogs. In our study, however, they were also observed in autonomic nerves surrounding the adrenal gland, a location in which they have not been reported before. The incidence in both locations were 8 of 32 Beagle dogs in the sciatic nerve and 6 of 40 Beagle dogs around the adrenal gland in the dosing and/or recovery phases of the study.

Active Bleeding in Uremic Patients after Temporary Catheter Implantation: A Case Report and Literature Review

2018 ◽  
Vol 04 (03) ◽  
Author(s):  
Chien Wen Chen ◽  
Xing Jia Liu ◽  
Szu Shan Fan ◽  
Hin Pin Chen ◽  
Chu Lin Chou
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Active Bleeding ◽  
Catheter Implantation ◽  
Uremic Patients

Renaut bodies in the sciatic nerve of beagle dogs

2001 ◽  
Vol 53 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Laura E. Elcock ◽  
Barry P. Stuart ◽  
Herbert E. Hoss ◽  
Kerry Crabb ◽  
Donna M. Millard ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Beagle Dogs ◽  
Renaut Bodies

The Clinical, Roentgenological and Morphological Effects of an Acute Exposure of Phosgene on the Lungs of Dogs

1971 ◽  
Vol 29 ◽  
pp. 236-237
Author(s):  
R. F. Bils ◽  
W. F. Diller ◽  
F. Huth
Keyword(s):  
Latent Period ◽  
Chemical Industry ◽  
Toxic Substance ◽  
Lung Edema ◽  
X Rays ◽  
Beagle Dogs ◽  
Male And Female ◽  
Morphological Alterations ◽  
Before And After ◽  
Electron Microscopes

Phosgene still plays an important role as a toxic substance in the chemical industry. Thiess (1968) recently reported observations on numerous cases of phosgene poisoning. A serious difficulty in the clinical handling of phosgene poisoning cases is a relatively long latent period, up to 12 hours, with no obvious signs of severity. At about 12 hours heavy lung edema appears suddenly, however changes can be seen in routine X-rays taken after only a few hours' exposure (Diller et al., 1969). This study was undertaken to correlate these early changes seen by the roengenologist with morphological alterations in the lungs seen in the'light and electron microscopes.Forty-two adult male and female Beagle dogs were selected for these exposure experiments. Treated animals were exposed to 94.5-107-5 ppm phosgene for 10 min. in a 15 m3 chamber. Roentgenograms were made of the thorax of each animal before and after exposure, up to 24 hrs.

Incorporation of Cholesterol into Peripheral Nerve Myelin

1972 ◽  
Vol 30 ◽  
pp. 334-335
Author(s):  
Frank A. Rawlins
Keyword(s):  
Electron Microscope ◽  
Sciatic Nerve ◽  
Electron Microscope Autoradiography ◽  
Myelin Sheaths ◽  
Microscope Autoradiography ◽  
Grain Distribution ◽  
Sciatic Nerves ◽  
Autoradiographic Analysis ◽  
Old Mice ◽  
Short Times

Several speculations exist as to the site of incorporation of preformed molecules into myelin. The possibility that an autoradiographic analysis of cholesterol-1,2-H3 incorporation at very short times after injection might shed some light in the solution of that problem led to the present experiment.Cholesterol-1,2-H3 was injected intraperitoneally into 24 tenday old mice. The animals were then sacrificed at 10,20,30,40,60,90,120 and 180 min after the injection and the sciatic nerves were processed for electron microscope autoradiography. To analyze the grain distribution in the autoradiograms of cross and longitudinal sections from each sciatic nerve myelin sheaths were subdivided into three compartments named: outer 1/3, middle 1/3 and inner 1/3 compartments.It was found that twenty min. after the injection of cholesterol -1.2-H3 (Figs. 1 and 2), 55% of the total number of grains (t.n.g) found in myelin were within the outer 1/3 compartment, 9% were within the middle 1/3 and 36% within the inner 1/3 compartment

Intraneuronal accumulations of lysosomes in the cerebellum of rats and dogs after dosing with MDL-832

1990 ◽  
Vol 48 (3) ◽  
pp. 830-831
Author(s):  
S.D. Barnard ◽  
S.D. Warner
Keyword(s):  
Brown Pigment ◽  
Beagle Dogs ◽  
Sprague Dawley ◽  
Gelatin Capsules ◽  
Pigment Granules ◽  
Sprague Dawley Rats ◽  
Hematoxylin And Eosin ◽  
Dose Levels

1, 2, 9, 10-tetramethoxyaporphine phosphate (MDL-832) was once considered a potential human antitussive. MDL-832 was administered orally in the diets of Sprague-Dawley rats at dose levels of 0, 5, 10, 20, 40, 80 and 160 mg/kg/day for 3 and 6 months and in gelatin capsules to Beagle dogs at 0, 5, 10, 15, 30 and 60 mg/kg/day for 3, 6 and 12 months. Histopathologic examinations of hematoxylin and eosin-stained cerebellar sections revealed intracytoplasmic brown pigment accumulations in large fusiform neurons (presumably the motor type) of the pons. The pigment granules were found to be PAS-positive, non-acid fast, iron-free, Sudan B-positive and fuchsinophilic. Intraneuronal pigment accumulations were seen in rats after 3 months of treatment at 80 mg but not at 40 mg and after 6 months at 20 mg but not at 10 mg. For dogs the effect was observed after 3 months at 60 mg but not at 30 mg and after 12 months at 10 mg but not at 5 mg.

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