SECRECY CODING IN THE INTEGRATED NETWORKENHANCED TELEMETRY (iNET)

This paper considers security in eavesdropping attacks over wireless communication links in aeronautical telemetry systems. Here, we propose a secure coding technique for the integrated Network Enhanced Telemetry (iNET) communications system that can be coupled with modern encryption schemes. We consider a wiretap scenario where there are two telemetry links between a test article (TA) and a legitimate receiver, or ground station (GS). We show how these two links can be used to transmit both encrypted and unencrypted data streams while keeping both streams secure.<br>

SECRECY CODING IN THE INTEGRATED NETWORKENHANCED TELEMETRY (iNET)

This paper considers security in eavesdropping attacks over wireless communication links in aeronautical telemetry systems. Here, we propose a secure coding technique for the integrated Network Enhanced Telemetry (iNET) communications system that can be coupled with modern encryption schemes. We consider a wiretap scenario where there are two telemetry links between a test article (TA) and a legitimate receiver, or ground station (GS). We show how these two links can be used to transmit both encrypted and unencrypted data streams while keeping both streams secure.<br>

Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”

This symposium synopsis summarizes key points discussed related to clinical pathology data interpretation for reproduction and juvenile toxicology studies. In pregnant and growing animals, several changes in clinical pathology parameters linked to growth/maturation of organ and physiological functions can occur, and understanding these changes is important to enable accurate interpretation of clinical pathology data. A brief overview of the general approach to clinical pathology data analysis according to contemporary practices is provided, followed by a discussion focused specifically on reproductive and juvenile clinical pathology. In this context, the approach to recognize and differentiate changes that may be related to pregnancy and growth as opposed to those that may be related to test article effects is highlighted.

Test article

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A Proposal for New Strategies in Dose Selection for 26-Week Tg.Rash2 Carcinogenicity Studies

Our experience indicates that extrapolation of doses from the maximum tolerated doses (MTD) derived from 4-week dose range finding (DRF) studies conducted in CByB6F1 may overpredict tolerability and undermine utility of the high-dose groups in 26-week carcinogenicity studies conducted in Tg.rasH2. In the 26-week carcinogenicity studies conducted in Tg.rasH2 mice, we analyzed the initial body weights, food consumption (FC), terminal body weights, body weight gain (BWG), mortality, and tumor incidence for vehicle and test article–treated dose groups for 26 studies conducted from 2014 to 2018. Although not statistically significant compared to the control dose group, the % BWG decreased in male mice of mid- and high-dose groups by >10%, whereas in females there were no differences. The mortality increased in a statistically significant manner for medium and high doses of males. In female mice, the mortality increased in the high-dose group but not in a statistically significant manner. When the cause of death (COD) was analyzed in all dose groups of both sexes, the COD due to tumors was highest in the control groups, whereas it was lowest in high-dose groups of both sexes. At the same time, the COD due to undetermined causes, which is possible indication of test article–induced toxicity, was highest in high-dose groups of both sexes. These findings together indicate that MTD derived from earlier DRF studies was exceeded when applied to 26-week carcinogenicity studies and did not serve any purpose in the outcome of these studies.