Nutritional Status-a Prognostic Indicator in Head and Neck Cancer

1985 ◽  
Vol 93 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Gerald B. Brookes
Keyword(s):  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Indicator ◽  
Nutritional Deficit ◽  
Significant Difference ◽  
Table Analysis ◽  
A Prospective Study ◽  
Index Estimation

A prospective study into the nutritional status of 114 patients with untreated primary squamous cell carcinoma of the head and neck was undertaken to assess its possible prognostic value for survival. Nutritional status was evaluated by anthropometry, creatinine height index estimation, serum albumin and transferrin assays, and nitrogen balance studies. Weight change and other anthropometric indices found to be the most reliable nutritional parameters were averaged to derive a clinically useful, general nutritional status score. A nutritional deficit was found in 43 of the 114 patients (37.7%) and was associated with neoplasms of the upper gastrointestinal tract in more than 80% of the patients. Life table analysis showed a statistically very highly significant difference between the survival of the adequately nourished patients (57.5% at 2 years) and the survival of the undernourished patients (7.5% at 2 years) (χ2 = 36.08; P = .0). These results indicate that nutritional deficiency is an important adverse prognostic factor in head and neck cancer. Undernutrition probably exerts its effect, at least in part, by causing secondary immunologic dysfunction.

scholarly journals Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer

Cancer ◽  
2015 ◽  
Vol 122 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Shin-Ae Kim ◽  
Jong-Lyel Roh ◽  
Sang-Ah Lee ◽  
Sang-wook Lee ◽  
Sung-Bae Kim ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Indicator

scholarly journals Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer

Cancer ◽  
2015 ◽  
Vol 122 (6) ◽  
pp. 971-972 ◽  
Author(s):  
Irma M. Verdonck-de Leeuw ◽  
Pim Cuijpers ◽  
C. Rene Leemans
Keyword(s):  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Prognostic Indicator

Nutritional status as a prognostic factor in advanced head and neck cancer

1998 ◽  
Vol 23 (4) ◽  
pp. 376-376
Author(s):  
Quak ◽  
Van Bokhorst ◽  
Klop ◽  
Van Leeuwen ◽  
Snow
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factor ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Advanced Head

Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status

2021 ◽  
pp. 019459982110045
Author(s):  
Nicolas Saroul ◽  
Mathilde Puechmaille ◽  
Céline Lambert ◽  
Achraf Sayed Hassan ◽  
Julian Biau ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Inflammatory Response ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Risk Index ◽  
Nutritional Risk ◽  
Inflammatory Status ◽  
Nutritional Risk Index

Objectives To determine the importance of nutritional status, social status, and inflammatory status in the prognosis of head and neck cancer. Study Design Single-center retrospective study of prospectively collected data. Setting Tertiary referral center. Methods Ninety-two consecutive patients newly diagnosed for cancer of the upper aerodigestive tract without metastases were assessed at time of diagnosis for several prognostic factors. Nutritional status was assessed by the nutritional risk index, social status by the EPICES score, and inflammatory status by the systemic inflammatory response index. The primary endpoint was overall survival. Results In multivariable analysis, the main prognostic factors were the TNM classification (hazard ratio [HR] = 3.34, P = .002, for stage T3-4), malnutrition as assessed by the nutritional risk index (HR = 3.64, P = .008, for severe malnutrition), and a systemic inflammatory response index score ≥1.6 (HR = 3.32, P = .02). Social deprivation was not a prognostic factor. Conclusion Prognosis in head and neck cancer is multifactorial; however, malnutrition and inflammation are important factors that are potentially reversible by early intervention.

scholarly journals EP-1125: Optimization of CT/MR image fusion protocol for GTV contouring in head and neck cancer: results of a prospective study

2013 ◽  
Vol 106 ◽  
pp. S424
Author(s):  
P. Antognoni ◽  
A. Leonardi ◽  
D. Doino ◽  
C. Mordacchini ◽  
R. Luraghi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prospective Study ◽  
Image Fusion ◽  
Head And Neck ◽  
Neck Cancer ◽  
Mr Image ◽  
A Prospective Study

scholarly journals Evaluation of the prevalence and severity of xerophthalmia in head and neck cancers patients undergoing curative radiotherapy

2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Sowmya V ◽  
Dipika Jayachander ◽  
Vijna Kamath ◽  
Mithun SK Rao ◽  
Mohammed Raees Tonse ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Keratoconjunctivitis Sicca ◽  
Study Objective ◽  
Cancer Group ◽  
Curative Radiotherapy ◽  
Significant Difference ◽  
Rectal Cancers

  Background: The study objective was to assess the development of xerophthalmia [dry eye syndrome (DES) or keratoconjunctivitis sicca] in head and neck cancer patients undergoing radiotherapy.Methods: Twenty two head and neck cancer patients requiring more than 60 Gy of curative radiotherapy/chemoradiotherapy and ten patients requiring radiotherapy/ chemoradiotherapy for treating cancers in the non head and neck regions (like breast, oesophagus, prostate, cervix and rectal cancers) were also enrolled in the study. The development of DES was studied at the beginning (day 0, before the start of radiotherapy) at day 21 (after completion of 30 Gy) and on completion of the treatment (> 60 Gy). As a comparative cohort, people with non head and neck cancer needing curative radiotherapy were also evaluated for comparison.Results: There was no difference in degree of DES between the Head and Neck cancer cohorts and non head and neck group at the beginning of treatment. However there was a statistically significant difference (p < 0.001) between the two groups at both mid and end of RT time point. Inter comparison between the various time points in the head and neck cancer group showed that the incidence of DES increased with the radiation exposure and was significant (pre to mid p < 0.001; and mid to end p < 0.005). A negative (r = -0.262) correlation was seen between DES and distance.Conclusions: The study showed that lesser the distance from the epicenter of the radiation to the orbital rim more was the severity of DES.

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