Reflex Control of Nasal Blood Vessels

1987 ◽  
Vol 96 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Shigeki Nishihira ◽  
Thomas V. Mccaffrey
Keyword(s):  
Blood Vessels ◽  
Nasal Mucosa ◽  
Vagus Nerves ◽  
Lung Inflation ◽  
Afferent Fibers ◽  
Reflex Arc ◽  
Capacitance Vessels ◽  
Nasal Blood Vessels ◽  
Pulmonary Stretch Receptor ◽  
Stimulation Of

The effect of stimulation of vagal afferent fibers on nasal blood vessels was studied in 36 cats. Volume change of the nasal capacitance vessels was measured by plethysmographic balloons inserted into the nose. Electrical stimulation of the vagus nerve produced a vasodilatation of nasal mucosa. Pulmonary stretch receptor stimulation by veratridine alkaloid and progressive lung inflation in open-chest cats also produced a vasodilatation of the nasal mucosa. These reflexes were abolished by sectioning the vagus nerves. These results suggest a reflex arc between the lung and nasal capacitance vessels which arises from pulmonary stretch receptors.

Reflex vasodilatation in the cat lip elicited by stimulation of nasal mucosa by chemical irritants

1993 ◽  
Vol 265 (4) ◽  
pp. R733-R738 ◽  
Author(s):  
H. Izumi ◽  
K. Karita
Keyword(s):  
Blood Flow ◽  
Electrical Stimulation ◽  
Nasal Mucosa ◽  
Threshold Dose ◽  
Ammonia Vapor ◽  
Autonomic Ganglion ◽  
Afferent Fibers ◽  
Autonomic Reflex ◽  
Chemical Irritants ◽  
Stimulation Of

Local application of capsaicin (threshold dose 150 microM) or nicotine (threshold dose 15 mM) to the nasal mucosa as well as electrical stimulation (threshold intensity 10 V) of the nasal mucosa elicited dose- or intensity-dependent blood flow increases in the ipsilateral lower lips of the anesthetized cats. Pretreatment with 3 mM capsaicin applied locally to the nasal mucosa abolished or reduced the vasodilation in response to capsaicin, nicotine, and ammonia vapor but not to light mechanical or electrical stimulation of the nasal mucosa. The blood flow increases elicited by all above stimuli were greatly reduced by pretreatment with hexamethonium, an autonomic ganglion blocker. These results suggest that stimulation of the nasal mucosa by chemical (capsaicin, nicotine, ammonia), mechanical, or electrical methods elicits the autonomic reflex vasodilatation in the cat lower lips. Furthermore, there seem to be at least two types of afferent fibers in the nasal mucosa of the cats: one type is capsaicin-sensitive fibers, while another type is capsaicin-resistant fibers involved in reflex vasodilatation.

An in Vitro Technique for Testing Nasal Vasodilating Agents

1980 ◽  
Vol 88 (4) ◽  
pp. 434-438 ◽  
Author(s):  
Richard T. Jackson
Keyword(s):  
Blood Vessels ◽  
Nasal Mucosa ◽  
Vasoactive Drugs ◽  
In Vitro Method ◽  
Nasal Decongestant ◽  
In Vitro Technique ◽  
Nasal Blood Vessels

An in vitro method for testing vasoactive drugs on nasal blood vessels is described. Isolated dog nasal mucosa contracts when treated with nasal decongestant or stimulated electrically. Vasodilating drugs inhibit this contraction. Atropine blocks the effects of acetylcholine on this tissue.

Vascular Effects of Neuropeptides on Nasal Mucosa

1988 ◽  
Vol 97 (3) ◽  
pp. 289-293 ◽  
Author(s):  
Keiichi Ichimura ◽  
Hiroyuki Mineda ◽  
Atsuro Seki
Keyword(s):  
Substance P ◽  
Neuropeptide Y ◽  
Blood Vessels ◽  
Nasal Mucosa ◽  
Vasoactive Intestinal Polypeptide ◽  
Muscle Tension ◽  
Vascular Effects ◽  
Tissue Contraction ◽  
Nasal Blood Vessels

We used dog nasal blood vessels and an in vitro muscle tension-detecting technique to examine the vascular effects of several neuropeptides: Vasoactive intestinal polypeptide, substance P, neurotensin, somatostatin, and neuropeptide Y (NPY). Electrically induced vasoconstriction was inhibited by every peptide except neurotensin, which enhanced this response. Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction. Only NPY caused a tissue contraction. Preparations precontracted by methoxamine were relaxed by every peptide. These results indicate that all peptides examined have marked but varied vasoactivities.

Effect of Chemoreceptor and Pulmonary Receptor Stimulation on Dilator Nares EMG Activity in the Dog

1983 ◽  
Vol 91 (6) ◽  
pp. 648-652 ◽  
Author(s):  
Daniel J. Blum ◽  
Thomas V. McCaffrey
Keyword(s):  
Upper Airway ◽  
Emg Activity ◽  
Receptor Stimulation ◽  
Lung Inflation ◽  
Anesthetized Dogs ◽  
Inspiratory Activity ◽  
Upper Airway Muscles ◽  
The Relationship ◽  
Pulmonary Stretch Receptor ◽  
Stimulation Of

To define the relationship between central control of upper airway muscles and respiratory muscle function, the electromyographic responses of the dilator nares muscles to stimulation of chemoreceptors and pulmonary receptors were studied in six anesthetized dogs. Only at maximal levels of hypoxia was the inspiratory activity of the dilator nares significantly increased. Hypercapnic stimulation increased the inspiratory activity with each incremental increase in CO2. Pulmonary stretch receptor stimulation produced by lung inflation inhibited dilator nares activity. Pulmonary irritant receptor stimulation by intravenously administered histamine increased dilator nares activity, as did pulmonary J receptor stimulation by the intravenous administration of capsaicin.

Laryngeal Regulation of Airway Resistance

1980 ◽  
Vol 89 (5) ◽  
pp. 462-466 ◽  
Author(s):  
Thomas V. McCaffrey ◽  
Eugene B. Kern
Keyword(s):  
Airway Resistance ◽  
Systemic Circulation ◽  
Regulation Of Respiration ◽  
Vagus Nerves ◽  
Receptor Stimulation ◽  
Lung Inflation ◽  
Pulmonary Receptor ◽  
Recurrent Laryngeal Nerves ◽  
Laryngeal Resistance ◽  
Stimulation Of

The response of laryngeal airway resistance to pulmonary receptor stimulation was studied in 20 mongrel dogs anesthetized with α-chloralose (80 mg/kg). Stimulation of pulmonary stretch receptors by lung inflation inhibited the phasic variation of laryngeal resistance during respiration and produced a sustained reduction of laryngeal resistance, which was related to lung inflation pressure. Stimulation of pulmonary J-receptors with capsaicin produced apnea and a large increase in laryngeal resistance. Capsaicin produced this reflex when injected into the pulmonary circulation but not when injected into the systemic circulation. Irritant receptor stimulation with histamine hydrochloride produced tachypnea and a reduction in inspiratory laryngeal resistance. Pulmonary receptor reflexes were abolished by dividing the vagus nerves distal to the origin of the recurrent laryngeal nerves. Laryngeal reflexes may be important in the regulation of respiration and the production of physiologic and pathologic alterations in pulmonary function.

Supraspinal inhibition of a cutaneous vascular reflex in the cat

1964 ◽  
Vol 207 (2) ◽  
pp. 303-307 ◽  
Author(s):  
B. J. Prout ◽  
J. H. Coote ◽  
C. B. B. Downman
Keyword(s):  
Carotid Sinus ◽  
Spinal Reflexes ◽  
Descending Pathways ◽  
Skin Response ◽  
Reflex Arc ◽  
Vascular Reflex ◽  
Carotid Sinus Nerve Stimulation ◽  
Sympathetic Discharge ◽  
Stimulation Of ◽  
Cerebellar Stimulation

In cats anesthetized with chloralose-urethane mixture, stimulation of an afferent nerve evoked a vasoconstrictor reflex (VCR) and a galvanic skin response (GSR) in the pads of the feet. Stimulation of the ventromedial medullary reticular substance at the level of the obex abolished the VCR and the GSR. VCR could also be reduced by occlusion during prolonged stimulation of another spinal or visceral afferent pathway. Medulla stimulation was effective without itself causing a sympathetic discharge to the paw, showing that inhibition rather than occlusion was operative. Anterior cerebellar stimulation also inhibited the VCR. Carotid sinus nerve stimulation did not abolish the VCR. It is concluded that the effective mechanism includes a bulbospinal inhibitory path projecting on a spinal vasoconstrictor reflex arc. This arrangement is similar to the descending pathways inhibiting other spinal reflexes but the VCR-inhibitory path can be activated independently of them.

scholarly journals Post-activation potentiation of gastric and intestinal contractions in response to stimulation of the vagus nerves

1959 ◽  
Vol 148 (2) ◽  
pp. 437-449 ◽  
Author(s):  
E. L. Blair ◽  
A. A. Harper ◽  
C. Kidd ◽  
T. Scratcherd
Keyword(s):  
Vagus Nerves ◽  
Stimulation Of
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