Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis

2017 ◽  
Vol 32 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Patrícia Pereira Alfredo ◽  
Jan Magnus Bjordal ◽  
Washington Steagall Junior ◽  
Rodrigo Álvaro Brandão Lopes-Martins ◽  
Martin B Stausholm ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Laser Therapy ◽  
Low Level Laser Therapy ◽  
Double Blind ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Strengthening Exercises

Objectives: To assess the long-term effects of low-level laser therapy (LLLT), in combination with strengthening exercises in patients with osteoarthritis of the knee. Design: Follow-up results at three and six months in a previously published randomized, double-blind, placebo-controlled trial. Setting: Specialist Rehabilitation Services. Subjects: Forty participants of both genders, aged 50–75 years with knee osteoarthritis grade 2–4 on Kellgren–Lawrence scale. Intervention: The LLLT group received 10 LLLT treatments with invisible infrared laser (904 nm, 3 Joules/point) over three weeks followed by an eight-week supervised strengthening exercise program. The placebo LLLT group received identical treatment, but the infrared laser output was disabled. Main measures: Pain on a visual analogue scale, paracetamol consumption, and osteoarthritis severity measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne Index. Results: The new data obtained during the follow-up period showed that all outcomes remained stable and there were no significant differences between the groups at three and six months. However, daily consumption of rescue analgesics (paracetamol) was significantly lower in the LLLT group throughout the follow-up period, ending at a group difference of 0.45 vs. 3.40 units ( P < 0.001) at six months follow-up. We conclude that within the limitations of this small study, the previously reported improvement after LLLT plus exercise was maintained for a period of six months. Conclusion: We find that the immediate post-intervention improvements from LLLT plus strengthening exercises were maintained for six months.

scholarly journals SHORT-TERM EFFICACY OF LOW-LEVEL LASER THERAPY IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL TRIAL

2011 ◽  
Vol 46 (5) ◽  
pp. 526-533 ◽  
Author(s):  
Vanessa Ovanessian Fukuda ◽  
Thiago Yukio Fukuda ◽  
Márcio Guimarães ◽  
Silvia Shiwa ◽  
Bianca Del Cor de Lima ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Laser Therapy ◽  
Low Level Laser Therapy ◽  
Short Term ◽  
Double Blind ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Double Blind Clinical Trial

Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study

2011 ◽  
Vol 26 (6) ◽  
pp. 523-533 ◽  
Author(s):  
Patrícia Pereira Alfredo ◽  
Jan Magnus Bjordal ◽  
Sílvia Helena Dreyer ◽  
Sarah Rúbia Ferreira Meneses ◽  
Giovana Zaguetti ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Laser Therapy ◽  
Blind Study ◽  
Low Level Laser Therapy ◽  
Double Blind Study ◽  
Double Blind ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

scholarly journals Efficacy of Low-Level Laser Therapy in the Management of Tinnitus due to Noise-Induced Hearing Loss: A Double-Blind Randomized Clinical Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Abolfazl Mollasadeghi ◽  
Seyyed Jalil Mirmohammadi ◽  
Amir Houshang Mehrparvar ◽  
Mohammad Hossein Davari ◽  
Pedram Shokouh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hearing Loss ◽  
Laser Therapy ◽  
Low Level Laser Therapy ◽  
Noise Induced Hearing Loss ◽  
Double Blind ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

Background. Several remedial modalities for the treatment of tinnitus have been proposed, but an effective standard treatment is still to be confirmed. In the present study, we aimed to evaluate the effect of low-level laser therapy on tinnitus accompanied by noise-induced hearing loss.Methods. This was a double-blind randomized clinical trial on subjects suffering from tinnitus accompanied by noise-induced hearing loss. The study intervention was 20 sessions of low-level laser therapy every other day, 20 minutes each session. Tinnitus was assessed by three methods (visual analog scale, tinnitus handicap inventory, and tinnitus loudness) at baseline, immediately and 3 months after the intervention.Results. All subjects were male workers with age range of 30–51 years. The mean tinnitus duration was1.85±0.78years. All three measurement methods have shown improved values after laser therapy compared with the placebo both immediately and 3 months after treatment. Laser therapy revealed a U-shaped efficacy throughout the course of follow-up. Nonresponse rate of the intervention was 57% and 70% in the two assessment time points, respectively.Conclusion. This study found low-level laser therapy to be effective in alleviating tinnitus in patients with noise-induced hearing loss, although this effect has faded after 3 months of follow-up. This trial is registered with the Australian New Zealand clinical trials registry with identifierACTRN12612000455864).

Doppelblinde, randomisierte, placebokontrollierte Low-Level-Laser Therapiestudie bei Patienten mit primärem Raynaudphänomen

VASA ◽  
2002 ◽  
Vol 31 (2) ◽  
pp. 91-94 ◽  
Author(s):  
Hirschl ◽  
Katzenschlager ◽  
Ammer ◽  
Melnizky ◽  
Rathkolb ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Low Level Laser Therapy ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Primary Raynaud’S Phenomenon

Background: No causal treatment of primary Raynaud’s phenomenon is available due to its unclear aetiology. Low level laser therapy (LLLT) is applied in a multitude of medical conditions often without sufficient evidence of efficacy and established mechanisms. To asses the effect of this therapy in patients with primary Raynaud’s phenomenon a randomised, double blind, placebo controlled cross over study was designed. Patients and methods: Absolute and relative frequency and intensity of vasospastic attacks during three weeks of either LLLT or placebo therapy and results of infrared thermography before onset and at the end of both therapy sequences were evaluated in 15 patients with primary Raynaud’s phenomenon. Results: Frequency of Raynaud’s attacks was not significantly affected by low level laser therapy. Compared to placebo a significantly lower intensity of attacks during laser irradiation was observed, but no transfer effect occurred. Additionally the mean temperature gradient after cold exposure was reduced after laser irradiation, while the number of fingers showing prolonged rewarming was unaffected. Conclusion: Though further studies are necessary to confirm these results we could demonstrate for the first time in a double blind placebo controlled clinical trial that low laser therapy is a potential candidate for an effective therapy of Raynaud`s phenomenon, although effects seem to be of short duration.

Ultrasound plus low-level laser therapy for knee osteoarthritis rehabilitation: a randomized, placebo-controlled trial

2018 ◽  
Vol 38 (5) ◽  
pp. 785-793 ◽  
Author(s):  
Fernanda Rossi Paolillo ◽  
Alessandra Rossi Paolillo ◽  
Jessica Patrícia João ◽  
Daniele Frascá ◽  
Marcelo Duchêne ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Laser Therapy ◽  
Controlled Trial ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

Follow-up of pressure ulcer treatment with photodynamic therapy, low level laser therapy and cellulose membrane

2021 ◽  
Vol 30 (4) ◽  
pp. 304-310
Author(s):  
Luciano Pereira Rosa ◽  
Francine Cristina da Silva ◽  
Suzete Carvalho Landulfo Luz ◽  
Regiane Lima Vieira ◽  
Beatriz Rocha Tanajura ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Therapy ◽  
Pressure Ulcer ◽  
Low Level Laser Therapy ◽  
Cellulose Membrane ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Hospitalised Patients

Objective: A pressure ulcer (PU) is an area of tissue trauma caused by continuous and prolonged pressure, often associated with hospitalised patients immobilised due to neurological problems, negatively affecting their quality of life, and burdening the public budget. The aim of this study was to report the follow-up, for 45 weeks, of three patients with neurological lesions due to trauma who subsequently developed PUs, and who were treated with a combination of photodynamic therapy (PDT), low level laser therapy (LLLT) and cellulose membrane (CM). Method: PDT was mediated by the photosensitiser curcumin on a 1.5% emulsion base. Blue LED light at 450 nm was delivered continuously for 12 minutes at an irradiance of 30mW/cm2 and total energy delivered to the tissue was 22J/cm2. LLLT was performed with 660 nm laser, punctuated and continuous, twice a week with parameters: spot size 0.04cm2, power of 40mW, 10 seconds per point, fluence of 10J/cm2 and irradiance of 1000mW/cm2. Results: All PUs had a significant reduction (range: 95.2–100%) of their area after 45 weeks of follow-up and two PUs had complete healing at 20 weeks and 30 weeks. All of the PUs showed a reduction in contamination with the PDT treatments in different proportions. Conclusion: From the results obtained, we conclude that the combination of PDT, LLLT and CM is a promising treatment for PU healing.

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