Efficacy of Low-Level Laser Therapy in Treatment of Recurrent Aphthous Ulcers – A Sham Controlled, Split Mouth Follow Up Study

Recurrent aphthous ulcers (RAUs) are the most common lesion found in the oral cavity. There is no definitive cure for RAUs and current treatments are aimed at minimizing symptoms. Since low-level laser therapy (LLLT) modulates inflammatory responses, and promotes pain reduction and cellular biostimulation, LLLT can be suggested as an alternative treatment for RAUs. The literature concerning the potential of LLLT in the treatment of RAUs was evaluated. A systematic literature review identified 22 publications, of which only 2 studies were adopted. The eligibility criteria consisted of randomized controlled trials (RCTs). Both RCTs achieved significant results concerning LLLT and pain-level reductions and reduced healing times. Despite the variance in irradiation conditions applied in both studies, very similar wavelengths were adopted. There is accordingly strong evidence that wavelength plays an important role in RAU treatment. Taking into account the different parameters applied by selected RCTs, it is not possible to suggest that a specific protocol should be used. However, in light of the significant results found in both studies, LLLT can be suggested as an alternative for RAU treatment. Additional RCTs should be performed in order to reach a clinical protocol and better understand the application of LLLT in RAU treatment.

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Comparative assessment of low-level laser therapy (LLLT) vs. topical application of amlexanox + lidocaine to treat recurrent aphthous ulcers (RAUs): A randomized controlled trial

Journal of Dental Research Dental Clinics Dental Prospects ◽

10.34172/joddd.2021.003 ◽

2021 ◽

Vol 15 (1) ◽

pp. 11-15

Author(s):

Charu Mohan Marya ◽

Jiksha Mehlawat ◽

Ruchi Nagpal ◽

Sakshi Kataria ◽

Pratibha Taneja

Keyword(s):

Laser Therapy ◽

Pain Perception ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Aphthous Ulcers ◽

Level Laser ◽

Recurrent Aphthous Ulcers ◽

Group 2 ◽

Group 1

Background. The present study aimed to assess and compare the pain perception and ulcer sizes before and after applying low-level laser therapy (LLLT) and Amlexanox + lidocaine. Methods. Twenty-six patients referring to the out-patient department of the institution and diagnosed with recurrent aphthous ulcers (RAU) were assigned to two groups to receive either LLLT or Amlexanox + lidocaine. In group 1, the patients were provided with amlexanox + lidocaine to apply topically four times daily. In group 2, the patients underwent LLLT with no tissue contact in inward circular motions for two cycles for 30 seconds. This study was registered in "the Clinical Trials Registry- India" (CTRI), with the registration number CTRI/2019/09/028222. The data were analyzed with SPSS 16. Results. The intergroup comparison was performed using Mann-Whitney U test, and intragroup comparisons were made using Wilcoxon’s signed-rank test. The level of significance was set at P<0.05. The results showed that pain perception and ulcer size were significantly lower in group 2 subjects than group 1 subjects (P<0.05). Conclusion. LLLT was more effective than amlexanox + lidocaine in the management of RAU. It is a cost-effective therapy for treating RAU.

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Low Level Laser Therapy (LLLT) in the Effective Management of Recurrent Aphthous Ulcers (RAU): Clinical Case Reporting 3 Patients: A Case Series

International Healthcare Research Journal ◽

10.26440/ihrj/0412.0399 ◽

2021 ◽

Vol 4 (12) ◽

pp. CR4-CR8

Author(s):

CM Marya ◽

Jiksha Mehlawat ◽

Ruchi Nagpal ◽

Pratibha Taneja

Keyword(s):

Laser Therapy ◽

Case Series ◽

Cost Effective ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Aphthous Ulcers ◽

Level Laser ◽

Reduction Of Pain ◽

Recurrent Aphthous Ulcers

Low-Level Laser therapy (LLLT) was employed for the treatment of three patients diagnosed with recurrent aphthous ulcers (RAU’s). The patients presented with recurrent aphthous ulcers in the region of floor of the mouth and buccal mucosa. The three patients with RAU’s were provided with a wavelength of946nm starting the use at 320µm fibre optic at a distance of 1-3 mm, peak power of 2W, frequency 10 Hz with no tissue contact in circular motion from outside to inside for 2 cycles with 100% duty for 30s for 3 consecutive days. The LLLT made possible an effective improvement in the reduction of pain and size associated with ulcers. It proved to be a safe and cost effective therapy in the management of recurrent aphthous ulcers.

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OI0294 Comparative study between low-level laser therapy and topical corticosteroids in aphthous ulcers

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2014.01.128 ◽

2014 ◽

Vol 117 (5) ◽

pp. e364

Author(s):

Hersheal Aggarwal ◽

Mohit Pal Singh ◽

Hemant Mathur ◽

G.V. Sowmya

Keyword(s):

Comparative Study ◽

Laser Therapy ◽

Low Level Laser Therapy ◽

Low Level ◽

Topical Corticosteroids ◽

Low Level Laser ◽

Aphthous Ulcers ◽

Level Laser

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Follow-up of pressure ulcer treatment with photodynamic therapy, low level laser therapy and cellulose membrane

Journal of Wound Care ◽

10.12968/jowc.2021.30.4.304 ◽

2021 ◽

Vol 30 (4) ◽

pp. 304-310

Author(s):

Luciano Pereira Rosa ◽

Francine Cristina da Silva ◽

Suzete Carvalho Landulfo Luz ◽

Regiane Lima Vieira ◽

Beatriz Rocha Tanajura ◽

...

Keyword(s):

Photodynamic Therapy ◽

Laser Therapy ◽

Pressure Ulcer ◽

Low Level Laser Therapy ◽

Cellulose Membrane ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Hospitalised Patients

Objective: A pressure ulcer (PU) is an area of tissue trauma caused by continuous and prolonged pressure, often associated with hospitalised patients immobilised due to neurological problems, negatively affecting their quality of life, and burdening the public budget. The aim of this study was to report the follow-up, for 45 weeks, of three patients with neurological lesions due to trauma who subsequently developed PUs, and who were treated with a combination of photodynamic therapy (PDT), low level laser therapy (LLLT) and cellulose membrane (CM). Method: PDT was mediated by the photosensitiser curcumin on a 1.5% emulsion base. Blue LED light at 450 nm was delivered continuously for 12 minutes at an irradiance of 30mW/cm2 and total energy delivered to the tissue was 22J/cm2. LLLT was performed with 660 nm laser, punctuated and continuous, twice a week with parameters: spot size 0.04cm2, power of 40mW, 10 seconds per point, fluence of 10J/cm2 and irradiance of 1000mW/cm2. Results: All PUs had a significant reduction (range: 95.2–100%) of their area after 45 weeks of follow-up and two PUs had complete healing at 20 weeks and 30 weeks. All of the PUs showed a reduction in contamination with the PDT treatments in different proportions. Conclusion: From the results obtained, we conclude that the combination of PDT, LLLT and CM is a promising treatment for PU healing.

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