scholarly journals Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

2016 ◽  
Vol 36 (4) ◽  
pp. 702-708 ◽  
Author(s):  
Ana Moraga ◽  
Vanessa Gómez-Vallejo ◽  
María Isabel Cuartero ◽  
Boguslaw Szczupak ◽  
Eneko San Sebastián ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Cerebral Ischemia ◽  
Emission Tomography ◽  
Toll Like Receptor ◽  
Resonance Imaging ◽  
Toll Like Receptor 4 ◽  
Positron Emission ◽  
Neuroimaging Techniques

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4−/− mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4−/− mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

The Role of Positron Emission Tomography/Magnetic Resonance Imaging in Gynecological Malignancies

2019 ◽  
Vol 43 (6) ◽  
pp. 825-834
Author(s):  
Mayur Virarkar ◽  
Chitra Viswanathan ◽  
Revathy Iyer ◽  
Silvana de Castro Faria ◽  
Ajaykumar Morani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Magnetic Resonance ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Gynecological Malignancies ◽  
Positron Emission

scholarly journals Implementation and role of modern musculoskeletal imaging in rheumatological practice in member countries of EULAR

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e000950
Author(s):  
Peter Mandl ◽  
Anna Ciechomska ◽  
L Terslev ◽  
Xenofon Baraliakos ◽  
PG Conaghan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Emission Tomography ◽  
Musculoskeletal Imaging ◽  
Resonance Imaging ◽  
Positron Emission

ObjectivesTo document the current training, implementation and role of modern musculoskeletal imaging techniques: ultrasound, magnetic resonance imaging, computed tomography and positron emission tomography, among rheumatologists in the member countries of the EULAR.MethodsEnglish-language questionnaires for each imaging modality developed by a EULAR task force were sent out to national and international scientific societies as well as imaging experts in the given modalities involved in research and/or training. The surveys were distributed via an online survey tool (SurveyMonkey). Simple descriptive and summary statistics were calculated from the responses.ResultsMore than 90% of ultrasound (US) experts reported the availability of a US unit in their department. Suspicion of rheumatoid arthritis and spondyloarthritides were the main clinical indications for performing US for diagnostic purposes. Suspicion of sacroiliitis and degenerative spine disease were the most common indications to perform magnetic resonance imaging (MRI) or computed tomography (CT) for diagnostic purposes, while positron emission tomography was mainly performed to diagnose large vessel vasculitis and to investigate fever of unknown origin. The reported percentage of rheumatologists performing US was highly variable, ranging from more than 80% in 6% of countries to less than 10% in 15% of countries. The majority of experts (77%) reported that their national rheumatology societies organise musculoskeletal US courses, while courses in MRI or CT organised by the national rheumatology societies were less commonly reported (29% and 8%, respectively).ConclusionsRheumatologists in Europe utilise modern imaging techniques; however, access to the techniques and training offered is varied.

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