Evaluation of vascular invasion in patients with musculoskeletal tumors of lower extremities: use of time-resolved 3D MR angiography at 3-T

Background Time-resolved angiography with stochastic trajectories (TWIST) sequence makes considerable progress in temporal and spatial resolution, which presents high potential in evaluation of vascular diseases. Purpose To assess magnetic resonance imaging (MRI) using TWIST MR angiography (MRA) sequence in the assessment of vascular invasion for bone and soft-tissue tumors in comparison to computed tomography angiography (CTA) as the reference standard. Material and Methods Thirty-three patients with lower extremity musculoskeletal tumors were imaged with conventional MR and TWIST MRA. CTA was performed 48 h later. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the femoral artery were calculated. Vascular invasion as determined by MRA and CTA was separately analyzed. Vascular invasion by MRA and CTA were analyzed with kappa coefficients to determine agreement between the imaging methods. Results Seven cases of bone and 26 cases of soft tissue tumors were examined. SNR and CNR of the femoral artery were excellent for TWIST MRA (mean ± SD values of 317 ± 80 and 276 ± 76, respectively). Based on the TWIST sequence, the vessels were free of tumor in 16 cases. Vascular displacement was found in 11 cases and vascular stenosis in six cases. The MRA findings conflicted with CTA findings in only one case. The kappa value was 0.953 ( P < 0.01). In five cases, vascular malformations were found with TWIST MRA but not CTA. Conclusion TWIST MRA enables accurate delineation of anatomical structures and tumor arterial involvement, providing reliable preoperative imaging information with respect to lower extremity musculoskeletal tumors.

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Diagnosis and Planning in the Management of Musculoskeletal Tumors - A Review

Faridpur Medical College Journal ◽

10.3329/fmcj.v11i2.32890 ◽

2017 ◽

Vol 11 (2) ◽

pp. 81-85

Author(s):

Md Hafizur Rahman ◽

Md Maiyeen Uddin

Keyword(s):

Soft Tissue ◽

Imaging Techniques ◽

Surgical Techniques ◽

Soft Tissue Tumors ◽

Chemotherapeutic Drugs ◽

Prognostic Information ◽

Image Guided ◽

Musculoskeletal Tumors ◽

The Past ◽

Appropriate Treatment

The prognosis of patients with musculoskeletal tumors has improved markedly because of the advent of new chemotherapeutic drugs and regimens and as a result of advances in imaging and surgical techniques. Limb-salvage operations can currently be performed with better outcomes, while in the past; limbs with tumors were treated only with amputation. Accurate preoperative surgical staging of musculoskeletal tumors is currently possible because imaging techniques provide prognostic information and aid clinicians in choosing the most appropriate treatment option for the patient. The aim of this article is to outline the presentation, imaging, and staging of the primary and metastatic bone and soft tissue tumors. Some of the image-guided interventions for these tumors are also presented.Faridpur Med. Coll. J. Jul 2016;11(2): 81-85

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Hemipelvectomy for the management of soft tissue tumors of the lower extremity

The American Journal of Surgery ◽

10.1016/0002-9610(64)90329-0 ◽

1964 ◽

Vol 107 (4) ◽

pp. 604-608 ◽

Cited By ~ 2

Author(s):

John T. Phelan ◽

James T. Grace ◽

George E. Moore

Keyword(s):

Soft Tissue ◽

Lower Extremity ◽

Soft Tissue Tumors

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RETRACTED: The diagnostic value of time-resolved MR angiography with Gadobutrol at 3T for preoperative evaluation of lower extremity tumors: Comparison with computed tomography angiography

European Journal of Radiology Open ◽

10.1016/j.ejro.2016.08.006 ◽

2016 ◽

Vol 3 ◽

pp. 239-244

Author(s):

Gang Wu ◽

Teng Jin ◽

Ting Li ◽

Xiaoming Li

Keyword(s):

Computed Tomography ◽

Lower Extremity ◽

Computed Tomography Angiography ◽

Mr Angiography ◽

Preoperative Evaluation ◽

Diagnostic Value ◽

Value Of Time ◽

Time Resolved

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Epidemiology of Osteosarcoma : Single Center Study in Indonesia

International Journal of PharmTech Research ◽

10.20902/ijptr.2019.130112 ◽

2020 ◽

Vol 13 (1) ◽

pp. 105-108

Author(s):

David Kalim ◽

Andriandi

Keyword(s):

Soft Tissue ◽

Bone Disease ◽

Bone Tumors ◽

Prevalence Ratio ◽

Soft Tissue Tumors ◽

Metastatic Bone Disease ◽

Primary Bone Tumors ◽

Musculoskeletal Tumors ◽

Musculoskeletal Tumour ◽

Primary Bone

Objective- To assess osteosarcoma epidemiology in Haji Adam Malik General Hospital. Material and Methods- This study is a retrospective descriptive study with a crosssectional approach. Patient with musculoskeletal tumour (especially osteosarcoma) in Haji Adam Malik Hospital from January 2012 to Desember 2017 period, got their age, gender, musculoskeletal tumour type, biopsy result, tumour sites, treatment completion, metastasis and amputation status recorded from their medical record. Result-Primary bone tumors is the most cases and found in 50% of musculoskeletal tumors followed by soft tissue tumors and metastatic bone disease. Male (60%) have slightly higher prevalence than female in (40%). The incidence of primary bone tumors shows osteosarcoma, GCT, and osteochondroma are in the top three with 63%, 13%, and 6% respectively. Specifically for osteosarcoma, male and female have 1.9 : 1 prevalence ratio. The most common sites for osteosarcoma is distal the femur (45%) and proximal tibia (29%). About 63% of patients undergo complete treatment and with 55% recorded with metastasis in the first diagnosis and amputation was performed in 89% of patients. Conclusion- Primary bone tumors dominate the data with 50% for musculoskeletal tumors followed by 31% soft tissue tumors and 19% metastatic bone disease. The incidence of musculoskeletal tumors shows that men are slightly higher than women in 60% and 40%. The incidence of primary bone tumors shows osteosarcoma, giant cell tumor, and osteochondroma are in the top three with 63%, 13%, and 6% respectively.

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Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors

Journal of Orthopaedic Surgery ◽

10.1177/23094990211057597 ◽

2021 ◽

Vol 29 (3) ◽

pp. 230949902110575

Author(s):

Sei Morinaga ◽

Shinji Miwa ◽

Norio Yamamoto ◽

Katsuhiro Hayashi ◽

Akihiko Takeuchi ◽

...

Keyword(s):

Soft Tissue ◽

Surgical Margin ◽

Positive Margin ◽

Soft Tissue Tumors ◽

Wide Excision ◽

Preoperative Imaging ◽

Malignant Soft Tissue Tumors ◽

Unplanned Excision ◽

Malignant Soft Tissue Tumor ◽

Malignant Soft Tissue

Introduction Malignant soft tissue tumors are rare tumors representing <1% of all malignancies. As these tumors are rare, it is not uncommon that malignant soft tissue tumor excision is performed without the required preoperative imaging, staging, or wide resection margins for sarcomas. The purpose of this study was to investigate the characteristics of patients with undergoing unplanned excisions. Risk factors for tumor recurrence and mortality in patients treated with unplanned excisions were also analyzed. Methods Forty-nine patients who underwent unplanned excision at other hospitals and additional wide excision at our hospital between January 2002 and December 2018 were identified. Among them, 42 patients with follow-up for more than 1 year were included in this retrospective study. The relationships between sex, age, tumor depth, histological grade, location, size, surgical margin at additional wide excision, residual tumor, reconstruction, kind of hospital where the primary excision was done (sarcoma vs non-sarcoma center), preoperative examination, chemotherapy, radiation therapy, and oncological outcomes were statistically analyzed. Results Mean patient age was 57.3 years (15–85 years) and the mean observation period was 72.5 months (14–181 months). This analysis showed 53.8% tumors that underwent unplanned excisions were small (<5 cm) and 70.7% tumors were superficial. Multivariate analysis revealed that a positive margin during additional wide excision was significantly associated with a lower 5-year LRFS ( p < 0.01). Conclusion Most of the tumors underwent unplanned excisions were small (<5 cm) and superficial. Surgeons should be aware that a positive margin during additional wide excision is an independent risk factor for local recurrence.

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5 Surgical Approach to Pediatric Bone and Soft-Tissue Tumors of the Lower Extremity

Lower Extremity Reconstruction ◽

10.1055/b-0041-179907 ◽

2021 ◽

Keyword(s):

Soft Tissue ◽

Lower Extremity ◽

Surgical Approach ◽

Soft Tissue Tumors

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Percutaneous Image-Guided Treatment of Benign Musculoskeletal Tumors in Children

Seminars in Musculoskeletal Radiology ◽

10.1055/s-0037-1608003 ◽

2018 ◽

Vol 22 (01) ◽

pp. 003-011 ◽

Cited By ~ 2

Author(s):

Anne Gill ◽

C. Hawkins ◽

Matthew O'Dell

Keyword(s):

Young Adults ◽

Soft Tissue ◽

Soft Tissue Tumors ◽

Research Interest ◽

Percutaneous Ablation ◽

Image Guided ◽

Musculoskeletal Tumors ◽

Children And Young Adults

AbstractPercutaneous ablation of benign musculoskeletal tumors in children has become an area of significant clinical growth over the last decade. With growing research interest, the technologies available and techniques used are becoming increasingly safe and effective. We review some of the more common ablation technologies and their utility in several common benign bone and soft tissue tumors that occur in children and young adults.

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