Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation

Objective This study was performed to assess the clinical and radiological outcomes of a revascularization procedure in immature teeth with apical periodontitis using platelet-rich plasma (PRP). The PRP protocol and conventional revascularization protocol, which used a blood clot as the scaffold, were compared. Methods Thirty non-vital immature permanent teeth were randomly categorized into two groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created using either PRP or a blood clot (control) and covered with white mineral trioxide aggregate. All cases were followed up clinically and radiographically for 12 months. Differences in bone density, root length, and lesion size were calculated using preoperative and postoperative computed tomography images. The means of the differences in individual parameters in the blood clot and PRP groups were compared using the Mann–Whitney U test. Results After 5 months, sensitivity tests (cold and electric pulp tests) elicited a delayed positive response in 23 sites. At 12 months, cone-beam computed tomography revealed resolution or a decrease in lesion size and an increase in bone density in all 30 (100%) teeth. Additionally, continued root development was observed in 22 (73%) teeth and early root growth was observed in the test group (mineral trioxide aggregate with PRP). Conclusions The results of this study suggest that PRP can serve as a successful scaffold for regenerative endodontic treatment. With the exception of a significant increase in root length, the results of treatment with PRP were not significantly different from those of the conventional protocol using a blood clot as the scaffold.

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The effect of platelet‐rich plasma as a scaffold in regeneration/revitalization endodontics of immature permanent teeth assessed using 2‐dimensional radiographs and cone beam computed tomography: a randomized controlled trial

International Endodontic Journal ◽

10.1111/iej.13303 ◽

2020 ◽

Vol 53 (7) ◽

pp. 905-921 ◽

Cited By ~ 2

Author(s):

A. S. ElSheshtawy ◽

H. Nazzal ◽

O. I. El Shahawy ◽

A. A. El Baz ◽

S. M. Ismail ◽

...

Keyword(s):

Computed Tomography ◽

Randomized Controlled Trial ◽

Cone Beam Computed Tomography ◽

Platelet Rich Plasma ◽

Controlled Trial ◽

Cone Beam ◽

Permanent Teeth ◽

Randomized Controlled

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Evaluation of a Novel Cone Beam Computed Tomography Scanner for Bone Density Examinations in Preoperative 3D Reconstructions and Correlation with Primary Implant Stability

Clinical Implant Dentistry and Related Research ◽

10.1111/cid.12193 ◽

2013 ◽

Vol 17 (5) ◽

pp. 844-853 ◽

Cited By ~ 23

Author(s):

Lars Sennerby ◽

Peter Andersson ◽

Luca Pagliani ◽

Claudio Giani ◽

Giacomo Moretti ◽

...

Keyword(s):

Computed Tomography ◽

Bone Density ◽

Cone Beam Computed Tomography ◽

Cone Beam ◽

Implant Stability ◽

3D Reconstructions ◽

Primary Implant ◽

Computed Tomography Scanner

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Quantitative evaluation of alveolar cortical bone density in adults with different vertical facial types using cone-beam computed tomography

The Korean Journal of Orthodontics ◽

10.4041/kjod.2014.44.1.36 ◽

2014 ◽

Vol 44 (1) ◽

pp. 36 ◽

Cited By ~ 14

Author(s):

Fulya Ozdemir ◽

Murat Tozlu ◽

Derya Germec Cakan

Keyword(s):

Computed Tomography ◽

Bone Density ◽

Cortical Bone ◽

Quantitative Evaluation ◽

Cone Beam Computed Tomography ◽

Cone Beam ◽

Cortical Bone Density ◽

Facial Types

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Evaluation of root maturation after revitalization in immature permanent teeth with nonvital pulps by cone beam computed tomography and conventional radiographs

International Endodontic Journal ◽

10.1111/iej.12705 ◽

2016 ◽

Vol 50 (9) ◽

pp. 836-846 ◽

Cited By ~ 13

Author(s):

P. Linsuwanont ◽

P. Sinpitaksakul ◽

T. Lertsakchai

Keyword(s):

Computed Tomography ◽

Cone Beam Computed Tomography ◽

Cone Beam ◽

Permanent Teeth

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Assessment of dehiscence and fenestration in children and adolescents using cone beam computed tomography

Dentistry 3000 ◽

10.5195/d3000.2021.143 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Aslıhan Akbulut ◽

Beyza Ballı Akgöl ◽

Kaan Orhan ◽

Merve Bayram

Keyword(s):

Computed Tomography ◽

Cone Beam Computed Tomography ◽

Primary Teeth ◽

Three Dimensions ◽

Cone Beam ◽

Permanent Teeth ◽

Type I ◽

Chi Square ◽

Children And Adolescent ◽

Adolescent Patients

Objectives: To define the prevalence of dehiscence and fenestration and classify them in terms of the localization of fenestrations in a random sampled group of children and adolescent patients using cone-beam computed tomography (CBCT).Methods: CBCT performed at the Department of Oral and Maxillofacial Radiology of patients referred by the paediatric dentistry clinic were included in this retrospective study. Image evaluations were performed by dentomaxillofacial radiologist (AA, asst. prof.), and these images were examined in three dimensions of the axial, coronal, and sagittal planes. Intraexaminer agreement for the evaluations were found acceptable. The presence/absence of dehiscence and/or fenestration, fenestration’s classification type, and localization of defects were recorded. Moreover, the presence/absence of periapical lesion in related root with dehiscence and fenestration was noted. For statistical analysis, The Chi-Square test, Fisher Freeman Halton Test, and Yates' Continuity of Correction were used.Results: 3061 roots in 1801 teeth of 120 cases were analyzed. The mean age was 9.97±2.22 years. Dehiscence was detected in 261(8.5%) roots of 161(8.9%) teeth, and fenestration was detected 63(2%) roots of 36(2%) teeth. The most common fenestration type was Type I, followed by Type II and IV. Dehiscence was observed more frequently in primary teeth than permanent teeth, and the difference was statistically significant (p:0.000). Dehiscence and fenestration incidence in maxillary teeth was significantly higher than in the mandibular teeth (pdehiscence:0.000, pfenestration:0.004). Apical lesions were observed more in primary teeth than permanent teeth for both defects.Conclusions: This study concludes that alveolar dehiscence and fenestrations are more common in primary teeth than permanent teeth. Moreover, these defects were detected more for the teeth in the maxilla. Concerning endodontic and orthodontic therapies in maxilla, use of CBCT is useful in determining the region's anatomical structure accurately in suspected cases of child and adolescent patients.

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