scholarly journals Intracytoplasmic sperm injection outcome of ejaculated spermatozoa from a man with mosaic Klinefelter's Syndrome: case report and literature review

2018 ◽  
Vol 46 (10) ◽  
pp. 4323-4331 ◽  
Author(s):  
Yang Yu ◽  
Qi Xi ◽  
Jili Jing ◽  
Linlin Li ◽  
Hongguo Zhang ◽  
...  
Keyword(s):  
Literature Review ◽  
Intracytoplasmic Sperm Injection ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertilization Rate ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome ◽  
Chromosome Pattern ◽  
Sperm Nuclei

Objective To report a case of abortion after intracytoplasmic sperm injection (ICSI) with ejaculated spermatozoa obtained from a man with mosaic Klinefelter’s syndrome. Methods Sperm nuclei from the patient were analyzed by fluorescence in situ hybridization, and the disomy frequencies for chromosome 18 and the sex chromosomes were determined. A literature review of the ICSI outcome of ejaculated sperm in patients with Klinefelter’s syndrome was also performed. Results A total of 108 spermatozoa nuclei were analyzed. Of these, 102 sperm cells were normal with an X18 (55.56%) or Y18 (38.89%) chromosome pattern. Three cells with XX18 (2.78%) and three cells with YY18 (2.78%) signals were detected. The fetus stopped developing in the eighth week. The karyotype determined by an analysis of the abortive tissue was 46, XY. The literature review identified a total of 12 patients who were analyzed in 11 reports. The fertilization rate was 80.9%, and the live birth rate per transfer was 71.4%. Conclusions ICSI with ejaculated spermatozoa from men with Klinefelter’s syndrome can lead to pregnancy, for which the risk of transmission of chromosomal aneuploidy is low.

scholarly journals Intracytoplasmic sperm injection with fresh versus cryopreserved testicular sperm in azoospermic patients

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Kani M. Falah
Keyword(s):  
Pregnancy Rate ◽  
Live Birth ◽  
Intracytoplasmic Sperm Injection ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Obstructive Azoospermia ◽  
Testicular Sperm

Abstract Background The purpose of this study is to compare the outcome of intracytoplasmic sperm injection (ICSI) using fresh sperm versus frozen-thawed sperm in both obstructed and non-obstructed azoospermias. This retrospective study included 159 ICSI cycles from 126 couples. In 91 obstructed azoospermia cases, 66 cycles were treated with fresh testicular sperm and 25 cycles were treated with frozen-thawed testicular samples. In 68 non-obstructed azoospermia cases, 32 cycles were treated with fresh testicular sperm and 36 cycles were treated with frozen-thawed testicular sperm, and the main measure and outcomes calculated are fertilization rate, clinical pregnancy, and live birth rate. Results In case of obstructed azoospermia, there were no statistically significant differences between fresh sperm and frozen-thawed testicular sperm used for ICSI regarding fertilization rate, clinical pregnancy rate, and live birth rate as shown (57%, 47%, 0.093 p value; 23.7%, 17.4%, 0.54 p value; and 11.9%, 8.7%, 0.68 p value, respectively). Non-obstructed azoospermia cases also show no significant differences in fertilization rate (37%, 36%, 0.91 p value), clinical pregnancy rate (20%, 14.3%, 0.58 p value), and live birth rate (4%, 3.6%, 0.93 p value). Conclusion Cryopreservation of testicular sperm is reliable if carried out before ovulation induction especially in cases with non-obstructive azoospermia

High fertilization rate with intracytoplasmic sperm injection in mosaic Klinefelter's syndrome

1995 ◽  
Vol 63 (1) ◽  
pp. 182-184 ◽  
Author(s):  
Offer Harari ◽  
Harold Bourne ◽  
Gordon Baker ◽  
Michael Gronow ◽  
Ian Johnston
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Fertilization Rate ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome ◽  
High Fertilization

scholarly journals Does Ovarian Endometriosis Increase Oocyte Sensitivity to ICSI-Induced Mechanical Damage?

2021 ◽  
Vol 10 (8) ◽  
pp. 1757
Author(s):  
Carlotta Scarafia ◽  
Martina Masciovecchio ◽  
Stefano Canosa ◽  
Andrea Roberto Carosso ◽  
Gianluca Gennarelli ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Birth Rate ◽  
Detrimental Effect ◽  
Mechanical Damage ◽  
Live Birth Rate ◽  
Clinical Pregnancy ◽  
Cumulative Live Birth Rate ◽  
Ovarian Endometriosis ◽  
Cumulative Live Birth

Some studies have shown that ICSI obtains poorer results than conventional IVF in women with ovarian endometriosis, suggesting that oocytes could be sensitive to ICSI-induced mechanical damage. The aims of this study were to clarify (a) whether ovarian endometriosis could induce peculiar fragility in the oocyte, so that ICSI would finally result harmful, and (b) whether endometrioma removal before IVF could be advisable in order to avoid any hypothetical detrimental effect. We retrospectively studied 368 women, 203 with in situ endometrioma (128 of which underwent ICSI, 75 conventional IVF) and 164 who received laparoscopic stripping of endometrioma before ICSI. For women with in situ endometrioma, cIVF and ICSI outcome was comparable for all parameters studied, including the clinical pregnancy rate per embryo transfer (PR/ET: 31.8% vs. 39.5% in the cIVF and ICSI groups) and cumulative live birth rate per ovum pick-up (CLBR/OPU: 24.4% vs. 27.7%). ICSI outcome was similar comparing women with in situ endometrioma and women previously submitted to laparoscopic stripping of cysts (CLPR/OPU 27.7% vs. 25.3%). Our findings suggest that (a) in women with in situ endometrioma ICSI may be performed, when needed, without harming oocytes and compromising the outcome and (b) that there is no advantage in removing endometrioma before ICSI.

Genetic Counseling in a Patient with XXY/XXXY/XY Mosaic Klinefelter’s Syndrome: Estimate of Sex Chromosome Aberrations in Sperm Before Intracytoplasmic Sperm Injection

1998 ◽  
Vol 69 (3) ◽  
pp. 482-485 ◽  
Author(s):  
Roland Kruse M.D. ◽  
Martina Guttenbach Ph.D. ◽  
Bettina Schartmann M.Sc. ◽  
Regine Schubert Ph.D. ◽  
Hans van der Ven M.D. ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Intracytoplasmic Sperm Injection ◽  
Chromosome Aberrations ◽  
Sex Chromosome ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome
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