scholarly journals Indocyanine green can stand alone in detecting sentinel lymph nodes in cervical cancer

2018 ◽  
Vol 46 (12) ◽  
pp. 4885-4897 ◽  
Author(s):  
Qurat Ulain ◽  
Lu Han ◽  
Qian Wu ◽  
Lanbo Zhao ◽  
Qi Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Human Serum ◽  
Detection Rate ◽  
Sentinel Lymph Nodes ◽  
Detection Rates ◽  
Pubmed Database

Objectives The effectiveness of indocyanine green (ICG) dye for detecting sentinel lymph nodes (SLNs) in cervical cancer compared with other tracers is unknown. This study aimed to assess the validity of ICG dye in detecting SLNs in cervical cancer preoperatively. Methods We performed a literature search for identifying eligible articles from PubMed database using the search terms “cervical cancer”, “sentinel lymph node”, “indocyanine green”, “blue dyes”, “human serum albumin”, and “technetium-99 radiocolloid”. We performed a meta-analysis. Comparison of the overall, bilateral, and unilateral detection rates of the different tracers was the primary goal. Comparison of the false-negative rate among the tracers was the secondary goal. Results Only eight retrospective studies including 661 patients were included. ICG versus combinations of three other tracers showed significantly higher bilateral and unilateral detection rates, but no difference in the overall rate of detecting SLNs. ICG had a higher bilateral detection rate than blue dye and technetium-99. Absorbing human serum albumin into ICG as a lymphatic tracer did not show a difference in detection rate compared with ICG alone. Conclusions ICG is superior and better than other tracers, and absorbing human serum albumin as a lymphatic tracer is not required in patients with cervical cancer.

scholarly journals Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review

2016 ◽  
Vol 27 (1) ◽  
pp. 154-158 ◽  
Author(s):  
Yasser Diab
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
High Sensitivity ◽  
Sentinel Lymph Node Mapping ◽  
Sentinel Lymph Nodes ◽  
Detection Rates ◽  
Lymph Node Mapping

ObjectiveA comprehensive literature search for more recent studies pertaining to sentinel lymph node mapping in the surveillance of cervical cancer to assess if sentinel lymph node mapping has sensitivity and specificity for evaluation of the disease; assessment of posttreatment response and disease recurrence in cervical cancer.Materials and MethodsThe literature review has been constructed on a step wise study design that includes 5 major steps. This includes search for relevant publications in various available databases, application of inclusion and exclusion criteria for the selection of relevant publications, assessment of quality of the studies included, extraction of the relevant data and coherent synthesis of the data.ResultsThe search yielded numerous studies pertaining to sentinel lymph node mapping, especially on the recent trends, comparison between various modalities and evaluation of the technique. Evaluation studies have appraised high sensitivity, high negative predictive values and low false-negative rate for metastasis detection using sentinel lymph node mapping. Comparative studies have established that of all the modalities for sentinel lymph node mapping, indocyanine green sentinel lymph node mapping has higher overall and bilateral detection rates. Corroboration of the deductions of these studies further establishes that the sentinel node detection rate and sensitivity are strongly correlated to the method or technique of mapping and the history of preoperative neoadjuvant chemotherapy.ConclusionsThe review takes us to the strong conclusion that sentinel lymph node mapping is an ideal technique for detection of sentinel lymph nodes in cervical cancer patients with excellent detection rates and high sensitivity. The review also takes us to the supposition that a routine clinical evaluation of sentinel lymph nodes is feasible and a real-time florescence mapping with indocyanine green dye gives better statistically significant overall and bilateral detection than methylene blue.

scholarly journals Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin

2012 ◽  
Vol 3 (9) ◽  
pp. 2306 ◽  
Author(s):  
Franklin Tellier ◽  
Jérôme Steibel ◽  
Renée Chabrier ◽  
François Xavier Blé ◽  
Hervé Tubaldo ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Human Serum ◽  
Fluorescence Detection ◽  
Sentinel Lymph Nodes ◽  
Patent Blue ◽  
Patent Blue V

scholarly journals Binding indocyanine green to human serum albumin potentially enhances the detection of sentinel lymph nodes. An initial step for facilitating the detection of first-station nodes in penile and other urological cancers

2021 ◽  
Author(s):  
Marcin Markuszewski ◽  
Magdalena Buszewska-Forajta ◽  
Małgorzata Artymowicz ◽  
Wojciech Połom ◽  
Marek Roslan ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Sentinel Node ◽  
Human Serum ◽  
Initial Step ◽  
Surgical Oncology ◽  
Fluorescence Measurements

IntroductionSurgical oncology strives to remove the primary cancer tumor together with its local lymphatic tissue. One of the techniques improving the staging of lymph nodes is sentinel node biopsy. The most common agent used in SNB is indocyanine green (ICG). Indocyanine green is characterized by its high affinity for human serum albumin (HSA). In practice, the visualization of the sentinel node is enhanced by attaching a relatively large carrier to the ICG molecule. The aim of this study was to investigate whether the covalent linking of ICG to a nanocolloid would extend the time of detection of the dye as it binds to HSA, assessed by fluorescence measurements in vitro.Material and methodsThe influence of the molar concentration of ICG on its ability to form a complex with HSA was investigated. The dye luminescence was measured, with an increasing amount of dye in the presence of a constant concentration of HSA. The stability of the ICG:HSA complex was also investigated.ResultsThe binding of ICG and human protein in a solution ratio of 3 : 1 made it possible to detect the ICG luminescence with better and prolonged visibility. In the case of the two lowest ratios, complex formation was not observed. The use of ICG bound to a nanocolloid based on human serum albumin increases the luminescence of the HSA:ICG complex up to 98%.ConclusionsProperly selected proportions of human albumin protein and ICH allowed higher and longer luminescence to be achieved. Nevertheless, further studies are necessary to establish the optimal concentration ratio.

Detection of the Communication Site by Indocyanine Green Adsorbed to Human Serum Albumin Fluorescence During Surgery for a Pleuroperitoneal Communication

2021 ◽  
Author(s):  
Daisuke Kimura ◽  
Ikuo Fukuda ◽  
Takeshi Fujita ◽  
Reiichi Murakami ◽  
Norio Nakamura ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Near Infrared ◽  
Thoracoscopic Surgery ◽  
Good Method ◽  
Pleuroperitoneal Communication ◽  
Fluorescence Images ◽  
One Year

Abstract A pleuroperitoneal communication is a serious complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Video-assisted thoracoscopic surgery is performed using indocyanine green adsorbed to human serum albumin fluorescence to identify the communication because human serum albumin reinforces fluorescence images. A patient diagnosed with a pleuroperitoneal communication was referred to our department and underwent surgery. To detect the communication, a dialysate mixture that contained indocyanine green and human serum albumin was injected from the CAPD catheter. Real-time fluorescence images were able to clearly show a bleb-like lesion with a near-infrared spectroscopy camera, and the site was repaired. The patient had no recurrence at one-year follow-up. This method might be good method for pleuroperitoneal communication surgery.

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