scholarly journals Ilizarov bone transport to treat infected nonunion of long bones: a multicenter retrospective cohort study

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052110027
Author(s):  
Jiang Xie ◽  
Guobin Zhao ◽  
Tayierjiang Yasheng ◽  
Hongtao Chen ◽  
Nuermaimaiti Amuti ◽  
...  
Keyword(s):  
Bone Healing ◽  
Functional Assessment ◽  
Bone Transport ◽  
Functional Evaluation ◽  
Long Bones ◽  
Trauma Centers ◽  
Infected Nonunion ◽  
Bone Nonunion ◽  
Study Population ◽  
Ilizarov Bone Transport

Objective To examine the efficacy and safety of Ilizarov bone transport in the treatment of infected nonunion of long bones. Methods Patients who underwent Ilizarov bone transport for treatment of bone nonunion with chronic osteomyelitis in the three largest regional orthopedic trauma centers in China from July 2013 to July 2018 were retrospectively examined. Treatment results were evaluated with Paley’s criteria for bone healing and functional assessment. Results In total, 189 patients were treated during the study period. The study population comprised 135 male and 54 female patients with an average age of 37.5 years (range, 11–61 years). The patients were followed up for at least 24 months. According to Paley’s criteria for bone healing and functional assessment, the bone healing results were excellent in 115 (61%) patients, good in 31 (16%), fair in 21 (11%), and poor in 22 (12%). The functional evaluation results were excellent in 76 (40%) patients, good in 65 (34%), fair in 22 (11%), poor in 26 (14%). Conclusion Infected nonunion of long bones can be effectively and safely treated with Ilizarov bone transport.

Preprocedural β-Blockers in the Functional Assessment of Intermediate Coronary Lesions by Instantaneous Wave-Free Ratio

Angiology ◽  
2021 ◽  
pp. 000331972199617
Author(s):  
Monica Verdoia ◽  
Rocco Gioscia ◽  
Matteo Nardin ◽  
Orazio Viola ◽  
Marta Francesca Brancati ◽  
...  
Keyword(s):  
Functional Assessment ◽  
Lesion Length ◽  
Functional Evaluation ◽  
Luminal Diameter ◽  
Coronary Syndrome ◽  
Coronary Stenoses ◽  
Minimal Luminal Diameter ◽  
Coronary Lesions ◽  
Β Blockers ◽  
The Impact

Aim: Instantaneous wave-free ratio (iFR) has emerged as the strategy of choice for the assessment of intermediate coronary lesions. The impact of preprocedural β-blockers therapy on the iFR was the aim of this study. Methods: We included patients undergoing functional assessment of intermediate (40%-70%) coronary lesions in 2 centers. The iFR measurement was performed by pressure-recording guidewire and calculated at the core laboratory using the manufacturers’ dedicated software. Minimal luminal diameter, reference diameter, percent diameter stenosis, and length of the lesion were measured. Positive iFR was considered for values <0.90. Results: We included 197 patients undergoing functional evaluation of 223 coronary lesions. Patients on β-blockers (69%) had more frequently hypertension ( P = .05); previous myocardial infarction ( P = .01); therapy with clopidogrel ( P = .02), statins, and aspirin; and acute coronary syndrome at presentation ( P < .001, respectively). Mean iFR values were slightly higher in patients on β-blockers (0.94 ± 0.06 vs 0.92 ± 0.06, P = .11). The rate of positive iFR was significantly lower with β-blockers (14.9% vs 27.5%, P = .04). On multivariate analysis, β-blockers use was a predictor of the significance of coronary stenoses (odds ratio [OR] = 0.48; 95% CI = 0.23-0.98; P = .05) together with lesion length (OR = 1.04; 95% CI = 1.01-1.07; P = .007). Conclusion: Among patients undergoing iFR, preprocedural β-blockers are associated with higher absolute values and a lower rate of positive iFR.

scholarly journals Quantitative and functional evaluation of endothelial progenitor cells in patients with cardiac amyloidosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
O Itzhaki Ben Zadok ◽  
D Leshem-Lev ◽  
T Ben-Gal ◽  
A Hamdan ◽  
N Schamroth-Pravda ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Mtt Assay ◽  
Cardiac Amyloidosis ◽  
Microvascular Dysfunction ◽  
Functional Evaluation ◽  
Endothelial Progenitor ◽  
Colony Forming Units ◽  
Study Population ◽  
And Function

Abstract Background Endothelial microvascular dysfunction is a known mechanism of injury in cardiac amyloidosis (CA), but evidence regarding the level and function of endothelial progenitor cells (EPCs) in patients with CA is lacking. Methods Study population included patients with light-chain or transthyretin (ATTR) CA. Patients with diagnosed heart failure and preserved ejection fraction (HFpEF) without monoclonal gammopathy and a 99mTc-DPD scan incompatible with TTR were used as controls. Blood circulating EPCs were assessed quantitatively by the expression of VEGFR-2(+), CD34(+) and CD133(+) using flow cytometry, and functionally by the formation of colony forming units (CFUs). MTT assay was used to demonstrate cell viability. Tests were repeated 3 months following the initiation of amyloid-suppressive therapies (either ATTR-stabilizer or targeted chemotherapy) in CA patients. Results Our preliminary cohort included 14 CA patients (median age 74 years, 62% ATTR CA). Patients with CA vs. patients with HFpEF (n=8) demonstrated lower expression of CD34(+)/VEGFR-2(+) cells [0.51% (IQR 0.4, 0.7) vs. 1.03% (IQR 0.6, 1.4), P=0.043] and CD133(+)/VEGFR-2(+) cells [0.35% (IQR 0.23, 0.52) to 1.07% (IQR 0.6, 1.5), P=0.003]. Functionally, no differences were noted between groups. Following the initiation of amyloid-suppressive therapies in CA patients, we observed the up-regulation of CD34(+)/VEGFR-2(+) cells [2.47% (IQR 2.1, 2.7), P&lt;0.001] and CD133(+)/VEGFR-2(+) cells [1.38% (IQR 1.1, 1.7), P=0.003]. Moreover, functionally, active EPCs were evident microscopically by their ability to form colonies (from 0.5 CFUs [IQR 0, 1.5) to 2 CFUs (IQR 1, 3.5), P=0.023]. EPCs' viability was demonstrated by an MTT assay [0.12 (IQR 0.04, 0.12) to 0.24 (IQR 0.16, 0.3), p=0.014]. Conclusions These preliminary results demonstrate reduced EPCs levels in CA patients indicating significant microvascular impairment. Amyloid-targeted therapies induce the activation of EPCs, thus possibly promoting endothelial regeneration. These findings may represent a novel mechanism of action of amyloid-suppressive therapies EPCs in CA patients and during therapy Funding Acknowledgement Type of funding source: None

Ilizarov bone transport using an intramedullary cable transportation system in the treatment of tibial bone defects

Injury ◽  
2020 ◽  
Author(s):  
Thomas Rosteius ◽  
Simon Pätzholz ◽  
Valentin Rausch ◽  
Sebastian Lotzien ◽  
Björn Behr ◽  
...  
Keyword(s):  
Bone Defects ◽  
Transportation System ◽  
Bone Transport ◽  
Tibial Bone ◽  
Ilizarov Bone Transport

Case 35: Periarticular Distal Tibial Infected Nonunion, Ankle Salvage with Bone Transport

2015 ◽  
pp. 247-254
Author(s):  
Mitchell Bernstein ◽  
S. Robert Rozbruch
Keyword(s):  
Bone Transport ◽  
Infected Nonunion

Two-Stage Reconstruction of Infected Nonunion of Long Bones using Antibiotics-Impregnated Cement Beads

2004 ◽  
Vol 17 (4) ◽  
pp. 395 ◽  
Author(s):  
Se Hyun Cho ◽  
Soon Taek Jeong ◽  
Hyung Bin Park ◽  
Sun Chul Hwang ◽  
Yong Chan Ha ◽  
...  
Keyword(s):  
Long Bones ◽  
Two Stage ◽  
Infected Nonunion

scholarly journals Comparison of Temporomandibular Disorders in Iranian Dental and Nondental Students

2012 ◽  
Vol 13 (2) ◽  
pp. 173-177 ◽  
Author(s):  
Farideh Bahrani ◽  
Parnian Ghadiri ◽  
Mahroo Vojdani
Keyword(s):  
Temporomandibular Disorders ◽  
Prevalence Ratio ◽  
Dental Students ◽  
Functional Evaluation ◽  
Chi Square ◽  
Total Study Population ◽  
Equal Distribution ◽  
High Prevalence ◽  
Chi Square Test ◽  
Study Population

ABSTRACT Aim The aim of this study was to define the prevalence and severity of temporomandibular disorders (TMD) among Iranian dental and nondental students who attended Shiraz University of Medical Sciences. Materials and methods The samples consisted of 200 subjects, 100 dental and 100 nondental students (equal distribution between males and females). Subjects ages ranged from 18 to 30 years (24.07 ± 2.93). A functional evaluation was performed using the Helkimo dysfunction index (Di). Data were evaluated by the Chi-square test. Results Among the total study population, 71% showed some degree of dysfunction. Prevalence ratio in dental students was 80%, while in nondental students was 62% (p < 0.05, odds ratio = 0.679). With respect to gender, women (80%) were more affected than men (62%). A significant relationship was found between gender and the occurrence of TMD (p < 0.05). Conclusion A high prevalence of signs of TMD in Iranian university students was seen which was greater in dental students and women. Clinical significance The results of this study showed that the prevalence of TMD among dental students and women was significantly higher than nondental students and men. These findings might be due to poor postural style or emotional stress during dental practice. How to cite this article Bahrani F, Ghadiri P, Vojdani M. Comparison of Temporomandibular Disorders in Iranian Dental and Nondental Students. J Contemp Dent Pract 2012;13(2): 173-177.

scholarly journals Infected nonunion of the long bones

2016 ◽  
Vol 2 (2) ◽  
pp. 68
Author(s):  
GamalAhmed Hosny
Keyword(s):  
Long Bones ◽  
Infected Nonunion

scholarly journals Ilizarov bone transport for the treatment of fibular osteomyelitis: a report of five cases

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Peng Yin ◽  
Lihai Zhang ◽  
Lining Zhang ◽  
Tongtong Li ◽  
Zhirui Li ◽  
...  
Keyword(s):  
Bone Transport ◽  
Ilizarov Bone Transport

High energy focused shock wave therapy accelerates bone healing

2015 ◽  
Vol 28 (06) ◽  
pp. 425-432 ◽  
Author(s):  
N. R. Kieves ◽  
C. S. MacKay ◽  
K. Adducci ◽  
S. Rao ◽  
C. Goh ◽  
...  
Keyword(s):  
Shock Wave ◽  
Bone Healing ◽  
Linear Regression Analysis ◽  
Scoring Systems ◽  
High Energy ◽  
Delayed Union ◽  
Osteotomy Site ◽  
Shock Wave Therapy ◽  
Sham Treatment ◽  
Study Population

SummaryObjectives: To evaluate the influence of shock wave therapy (SWT) on radiographic evidence of bone healing after tibial plateau leveling osteotomy (TPLO).Methods: Healthy dogs between two to nine years of age that underwent TPLO were randomly assigned to receive either electro- hydraulic SWT (1,000 shocks) or sham treatment (SHAM). Treatment or SHAM was administered to the osteotomy site immediately postoperatively and two weeks postoperatively. Three blinded radiologists evaluated orthogonal radiographs performed eight weeks postoperatively with both a 5-point and a 10-point bone healing scale. Linear regression analysis was used to compare median healing scores between groups.Results: Forty-two dogs (50 stifles) were included in the statistical analysis. No major complications were observed and all osteo -tomies healed uneventfully. The median healing scores were significantly higher at eight weeks postoperatively for the SWT group compared to the SHAM group for the 10-point (p <0.0002) and 5-point scoring systems (p <0.0001).Clinical significance: Shock wave therapy applied immediately and two weeks post -operatively led to more advanced bone healing at the eight week time point in this study population. The results of this study support the use of electro-hydraulic SWT as a means of accelerating acute bone healing of canine osteotomies. Additional studies are needed to evaluate its use for acceleration of bone healing following fracture, or with delayed union.

Infected Nonunion of Long Bones Treated with Dual Plate

1997 ◽  
Vol 32 (7) ◽  
pp. 1701 ◽  
Author(s):  
Hak Jin Min ◽  
Keun Woo Kim ◽  
Kook Hyeong Cho ◽  
Yong Hoon Kim ◽  
Ui Seoung Yoon ◽  
...  
Keyword(s):  
Long Bones ◽  
Infected Nonunion ◽  
Dual Plate
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