Primary squamous cell carcinoma of the liver: a case report

Primary squamous cell carcinoma of the liver is extremely rare, very difficult to diagnose, and carries an extremely poor prognosis. In this study, we discuss the imaging features of a patient with primary hepatic squamous cell carcinoma. The patient was admitted to hospital owing to discomfort in the right upper abdominal quadrant and a loss of appetite. He had no previous risk factors associated with hepatic squamous cell carcinoma and no history of systemic squamous cell carcinoma. We diagnosed primary hepatic squamous cell carcinoma by pathological analysis. Primary hepatic squamous cell carcinoma is rare, and its histological features are controversial, which makes the clinical and imaging diagnosis difficult. Therefore, it is urgent to improve the understanding of this disease in clinical practice to avoid misdiagnosis, and to identify the best treatment. This case provides a basis for the clinical diagnosis of primary hepatic squamous cell carcinoma.

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Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

Case Reports in Urology ◽

10.1155/2015/469327 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Tapan Kumar Sahoo ◽

Saroj Kumar Das ◽

Chandraprava Mishra ◽

Ipsita Dhal ◽

Rohani Nayak ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radical Nephrectomy ◽

Advanced Stage ◽

Rare Entity ◽

Primary Squamous Cell Carcinoma ◽

Review Of The Literature ◽

Radiological Features ◽

The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

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Metastasis of cutaneous squamous cell carcinoma to the stomach: a rare entity

BMJ Case Reports ◽

10.1136/bcr-2020-238731 ◽

2020 ◽

Vol 13 (11) ◽

pp. e238731

Author(s):

Marica Reise-Filteau ◽

Michael Carter ◽

Ryan DeCoste ◽

Ali Kohansal

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Functional Decline ◽

Cutaneous Squamous Cell Carcinoma ◽

Rare Entity ◽

Gastric Tumour ◽

Comprehensive Genomic Profiling ◽

History Of ◽

The Right

Metastatic spread of cutaneous squamous cell carcinoma (cSCC) to the gastrointestinal tract is a rare entity. A 63-year-old woman with a history of poorly controlled HIV and a recurrent cSCC on the right temple presented with functional decline, ascites and shortness of breath. A CT scan showed widespread metastatic malignancy involving lung, pleura, heart, stomach, liver, retroperitoneum and soft-tissue. In the case presented here, an upper endoscopy revealed a submucosal lesion in the stomach. Biopsies described the lesion as a poorly differentiated SCC. Comprehensive genomic profiling yielded striking molecular similarities between the gastric tumour and the patient’s prior cSCC. It confirmed the origin of the disease and excluded spread from an occult primary. This case adds to the limited literature on gastrointestinal metastases of cSCC and serves as a reminder that non-AIDS-defining cancers are on the rise in the HIV-population.

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Squamous Cell Carcinoma of the Renal Pelvis Associated with Kidney Stones: Radiologic Imaging Features with Gross and Histopathological Correlation

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.109741 ◽

2013 ◽

Vol 3 ◽

pp. 14 ◽

Cited By ~ 11

Author(s):

Ozlem Tugce Kalayci ◽

Zehra Bozdag ◽

Fitnet Sonmezgoz ◽

Nurhan Sahin

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Renal Pelvis ◽

Stone Disease ◽

Imaging Features ◽

Histopathological Correlation ◽

Radiologic Imaging ◽

Radiologic Investigation ◽

The Right

Squamous cell carcinoma (SCC) of the renal pelvis is a rare neoplasm and is usually associated with long standing renal stone disease. This tumor is aggressive in nature and usually has a poor prognosis. We report a case who presented with sudden significant weight loss. During the radiologic investigation, a renal mass and staghorn calculi were detected in the right kidney. The patient subsequently underwent right radical nephrectomy. Pathological diagnosis was SCC of renal pelvis with extensive infiltration in to the renal parenchyma. The radiologic imaging features and histopathologic findings of this rare tumor are discussed in this report.

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Primary squamous cell carcinoma of the breast: a rare entity, representation of two cases

International Surgery Journal ◽

10.18203/2349-2902.isj20173434 ◽

2017 ◽

Vol 4 (8) ◽

pp. 2848

Author(s):

Yoshitha Siripurapu ◽

Bhawna Dev ◽

Ramya Ramakrishnan ◽

Sandhya Sundaram

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hormone Receptors ◽

Final Diagnosis ◽

Histopathological Diagnosis ◽

Primary Squamous Cell Carcinoma ◽

Carcinoma Of The Breast ◽

History Of ◽

Invasive Breast Carcinomas

The aim of this study was to diagnose primary squamous cell carcinoma of the breast with clinical, radiological, pathological correlation. We report two cases of primary squamous cell carcinoma of the breast. Both the patients presented with a palpable lump, with no family history of breast carcinoma. Post-operative histopathological diagnosis was squamous cell carcinoma with immunohistochemistry positive for p63 and negative for hormone receptors. Primary squamous cell carcinoma (SqCC) of the breast is a very rare tumor accounting for less than 0.1% of all invasive breast carcinomas. It is known to be a very aggressive which is a hormone receptor negative and is treatment refractory tumor with poor prognosis. In both our cases, a final diagnosis of SqCC was made after an extensive work up for primary or metastatic disease.

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Rare squamous cell carcinoma of the kidney with concurrent xanthogranulomatous pyelonephritis: A case report and review of the literature

Open Medicine ◽

10.1515/med-2020-0233 ◽

2021 ◽

Vol 16 (1) ◽

pp. 128-133

Author(s):

Tsung-Hsin Chang ◽

Jen-Shu Tseng

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radical Nephrectomy ◽

Medical Literature ◽

Xanthogranulomatous Pyelonephritis ◽

Rare Presentation ◽

English Medical Literature ◽

History Of ◽

The Right

Abstract Case presentation In the current study, we report a 69-year-old female patient who was initially diagnosed with xanthogranulomatous pyelonephritis (XGPN) with nephrolithiasis and a peri-renal abscess. She presented to our department with right flank pain. Physical examination revealed right costovertebral angle knocking pain and computed tomography revealed dilated calyces and one staghorn stone over right kidney, with multiple abscess accumulations over the right peri-renal region. Right radical nephrectomy was performed using a transperitoneal flank approach, and pathology revealed squamous cell carcinoma (SCC) with concurrent XGPN. The patient was alive at 4 months post-operative follow-up. To the best of our knowledge, this is only the fifth case of renal SCC with concurrent XGPN reported in the English medical literature. Conclusion Renal SCC with coexisting XGPN is an extremely rare presentation and only four cases have been previously reported in the English medical literature. A positive diagnosis for this rare combination of diseases was established, based on pathological and immunohistochemical examinations after radical nephrectomy. Poor prognosis has been reported in such cases. Malignancies should be considered in patients with a long-standing history of urolithiasis.

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A Report on Synchronous Polymorphous Low-grade Adenocarcinoma and Unknown Primary Squamous Cell Carcinoma

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1251 ◽

2015 ◽

Vol 6 (4) ◽

pp. 181-186

Author(s):

Adam D Fisher ◽

Shawn A McClure ◽

Johnny Franco

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Unknown Primary ◽

Low Grade ◽

Primary Squamous Cell Carcinoma ◽

Cervical Lymph Nodes ◽

The Right

ABSTRACT Background This is a case report of synchronous, noncollision head and neck malignancies, consisting of a large polymorphous low-grade adenocarcinoma (PLGA) and an unknown primary squamous cell carcinoma (SCC) that was diagnosed on final pathology. Materials and methods Positron emission tomography– computed tomography (CT) scan with and without contrast was obtained, which showed a large destructive soft tissue mass emanating from the right maxilla into the right maxillary sinus with invasion into the surrounding tissue and bone, compatible with an underlying primary maxillary malignancy. Increased D-18 fluorodeoxyglucose activity was also seen in the neck corresponding to numerous bilateral cervical lymph nodes. Magnetic resonance imaging showed the extent of the soft tissue mass, which expanded to the inferior aspect of the right orbital floor, with no evidence of gross invasion into the orbit. Results The patient underwent a subtotal maxillectomy, bilateral modified radial neck dissection, and reconstruction. Pathology revealed metastatic PLGA present in the right cervical lymph nodes. Left cervical lymph nodes, however, revealed metastatic SSC. The patient was taken back to the operating room and a panendoscopy was performed. Physical examination was benign and multiple biopsies were negative for SSC. The patient underwent radiation therapy for PLGA and unknown primary SSC antigen. Conclusion Synchronous tumors of the head and neck are seldom reported and they present unique treatment challenges. This case report discusses the diagnosis, management, and unique nature of two malignant synchronous noncollision tumors in the head and neck. How to cite this article Fisher AD, McClure SA, Franco J. A Report on Synchronous Polymorphous Low-grade Adenocarcinoma and Unknown Primary Squamous Cell Carcinoma. Int J Head Neck Surg 2015;6(4):181-186.

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Squamous Cell Carcinoma and Multiple Bowen's Disease in a Patient with a History of Consumption of Traditional Chinese Herbal Balls

Case Reports in Dermatology ◽

10.1159/000437250 ◽

2015 ◽

Vol 7 (2) ◽

pp. 151-155 ◽

Cited By ~ 4

Author(s):

Joon Seok ◽

Kui Young Park ◽

Kapsok Li ◽

Beom Joon Kim ◽

Joo Hyun Shim ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Skin Lesions ◽

Sufficient Evidence ◽

Bowen’S Disease ◽

Bowen's Disease ◽

Chinese Herbal ◽

History Of ◽

The Right

Arsenic has been classified as a class I human carcinogen, meaning that there is sufficient evidence of carcinogenicity to humans. Arsenic, however, remains a common contaminant in a number of traditional Chinese herbal balls. A 64-year-old man presented with an erythematous erosive patch on the left palm, multiple yellowish scaly patches on the right palm and an erythematous hyperkeratotic patch with bleeding on the left foot dorsum. He also had similar skin lesions on the back and buttock. He had a past medical history of chronic exposure to arsenic through consumption of traditional Chinese herbal balls. Skin biopsy revealed Bowen's disease on the left palm and squamous cell carcinoma on left foot dorsum. We report this case to emphasize that we should investigate patient's history thoroughly, including the use of Chinese herbal balls to find out arsenicism.

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Conjunctival Inverted Papilloma Progressing to Carcinoma. First Report in Horse

Veterinary Sciences ◽

10.3390/vetsci8060108 ◽

2021 ◽

Vol 8 (6) ◽

pp. 108

Author(s):

Vito Biondi ◽

Annamaria Passantino ◽

Michela Pugliese ◽

Salvatore Monti ◽

Alessandra Sfacteria ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Inverted Papilloma ◽

Ophthalmological Examination ◽

First Report ◽

Arabian Horse ◽

History Of ◽

The Right

A five-year-old, entire female Arabian horse with a 6-month history of a non-painful nodule on the conjunctiva of the right eye was evaluated. Ophthalmological examination showed a firm, smooth and fleshy conjunctival mass that raised the suspicion of a conjunctival neoplasm. Histological evaluations showed that the mass was composed of an endophytic growth consisting of numerous long papillary projections of hyperplastic stratified squamous epithelium supported by thin fibrovascular stalks. Typical features of squamous cell carcinoma with disorganized cell growth and infiltration of surrounding tissues were detectable within the mass. Inverted papilloma progressing to carcinoma was diagnosed. Follow-up examination showed that no local recurrence was present during the 12-month follow-up period. To the authors’ knowledge, this is the first report describing the inverted papilloma in the horse and, due to its progression to squamous cell carcinoma, warns about the inclusion of the inverted papilloma in the differential diagnosis of conjunctival neoplasm and driven treatments.

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Reconstruction of Large Nasal Alar Squamous Cell Carcinoma Defect Using a Superiorly - Based Nasolabial Flap

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v35i2.1521 ◽

2020 ◽

Vol 35 (2) ◽

pp. 55

Author(s):

Jan Caezar Cordero

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Outpatient Clinic ◽

Alar Cartilage ◽

Nasolabial Flap ◽

Cervical Lymph Nodes ◽

Nasal Ala ◽

History Of ◽

The Right

The nasal skin is the most common site of malignancy in the face accounting for as much as 25.5 percent by virtue of its location and propensity for direct exposure to ultraviolet radiation from the sun.1-3 Among the various cutaneous malignancies, basal cell carcinoma is the most ommon, but other types of cancer such as squamous cell carcinoma, cutaneous malignant melanoma, and basosquamous carcinoma are also common.4 Following surgical resection of a malignant lesion, the defect calls for a reconstructive option that will restore aesthetics and function. We present a squamous cell carcinoma of the nasal alar skin which underwent excision and reconstruction of the defect using a superiorly - based nasolabial flap. CASE REPORT A 66-year-old man consulted at the outpatient clinic due to a nasal alar mass on the right. The mass started one year prior to consult as a pimple-like lesion on the right nasal ala. There was no history of manipulation or trauma to the aforementioned area. He consulted at a local hospital where he was given unrecalled antibiotics that did not cure the lesion. Instead, he noticed that it gradually enlarged, and a deep ulceration developed within the mass. This prompted consult at our outpatient clinic where a 3 x 2 cm ulcerating mass with crusting and necrotic areas was noted on his right nasal ala. (Figure 1) Anterior rhinoscopy showed an intact mucosa in the right nostril with no gross evidence of tumor involvement. There were no enlarged cervical lymph nodes palpated in the neck. A wedge biopsy revealed a well-differentiated squamous cell carcinoma. He claimed that he had no family history of cutaneous malignancy. However, he had a 20 pack-year history of smoking and was a heavy alcoholic beverage drinker. He previously worked as an electrician and denied chronic exposure to sunlight. He consequently underwent excision of the right nasal alar mass with 5-mm margin. (Figure 2A, B) A histologic evaluation of the margins revealed that the borders and tumor base were negative for malignancy. The alar cartilage was not involved by tumor. Reconstruction of the defect was done using a superiorly - based nasolabial flap on the right. (Figure 3A, B, C) Two weeks postoperatively, the patient came in for follow-up with a healed, aesthetically - pleasing, and well-coaptated wound. (Figure 4) He remains free of any evidence of recurrence after 1 year.

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Primary Squamous Cell Carcinoma Thyroid with Regional Recurrence

BioScientia Medicina ◽

10.32539/bsm.v5i4.405 ◽

2021 ◽

Vol 5 (4) ◽

pp. 1160-1165

Author(s):

Nugroho Akhbar ◽

Benny Issakh

Keyword(s):

Squamous Cell Carcinoma ◽

Thyroid Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Undifferentiated Carcinoma ◽

Regional Hospital ◽

Primary Squamous Cell Carcinoma ◽

Case Presentation ◽

Thyroid Malignancies ◽

The Right

Background. Primary squamous cell carcinoma (PSCC) of the thyroid is a very aggressive malignancy with a poor prognosis. There is no consensus for the management of primary squamous cell carcinoma (PSCC) of the thyroid, and this is based on rare cases in which the frequency of occurrence is less than 1% of thyroid malignancies. How squamous cell carcinoma originates in the thyroid gland is an interesting topic to discuss, because the thyroid gland does not have a squamous cell epithelium. Case Presentation. A 43-year-old man was admitted to the DR Kariadi Hospital with complaints of a lump on the right neck. In June 2020, the patient complained of a lump in the right neck area with a diameter of about 1x1x1 cm, no pain. Ultrasound of the colli at the regional hospital showed the impression of multiple lymphadenopathy of the right colli level 2-5, and there were cystic nodules with solid parts in the right and left lobes of the thyroid suspected of being benign. An adenectomy operation was performed at a regional hospital and the impression of metastatic squamous undifferentiated carcinoma was obtained. Conclusion. The management of thyroid PSCC is a multimodality therapy, namely surgery, chemotherapy and radiation.

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