scholarly journals Severe pulmonary co-infection with varicella-zoster virus, Pneumocystis jirovecii and Cytomegalovirus: a case report

2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110707
Author(s):  
Zhijiang Qi ◽  
Yanting Sun ◽  
Jun Li ◽  
Yingjie Wang ◽  
Haining Lu ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Varicella Zoster Virus ◽  
Pneumocystis Jirovecii ◽  
Imaging Features ◽  
Severe Respiratory Failure ◽  
Next Generation ◽  
Varicella Zoster ◽  
Immunosuppressed Patients ◽  
Generation Sequencing

Pneumocystis jirovecii, Cytomegalovirus and varicella-zoster virus are all opportunistically infective pathogens, but pulmonary co-infection with these pathogens is rare. Herein, this case report describes a patient with autoimmune haemolytic anaemia treated with methylprednisolone and cyclosporine that presented with rapidly progressive severe respiratory failure. Analysis of microbial nucleic acid sequences in both blood and sputum using next-generation sequencing revealed pulmonary co-infection with Pneumocystis jirovecii, varicella-zoster virus, and possibly Cytomegalovirus. After timely targeted and supportive treatments, the patient recovered. This case report highlights the imaging features of co-infection with these pathogens, the importance of next-generation sequencing for early diagnosis in immunosuppressed patients, and the effects of corticosteroid therapy.

scholarly journals A case of paraplegia due to asymptomatic varicella-zoster virus infection in AIDS patient unexpectedly diagnosed by CSF metagenomic next-generation sequencing

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhiman Xie ◽  
Jingzhen Lai ◽  
Chuanyi Ning ◽  
Guangjing Ruan ◽  
Hao Liang
Keyword(s):  
Spinal Cord ◽  
Next Generation Sequencing ◽  
Varicella Zoster Virus ◽  
Disease Diagnosis ◽  
Next Generation ◽  
Thoracic Spinal Cord ◽  
Varicella Zoster ◽  
Thoracic Spinal ◽  
Generation Sequencing ◽  
Hiv Aids

Abstract Background Varicella-zoster virus (VZV) infection may induce central nervous system complications in HIV/AIDS patients. However, it is rare to have paraplegia caused by VZV infection but no herpes zoster clinically. Asymptomatic VZV infection in HIV/AIDS patient increased the difficulty of diagnosis. Case presentation We reported a 41-year-old male AIDS patient with rare asymptomatic VZV infection-induced paraplegia after his anti-retroviral therapy initiation. MRI of the spinal cord showed the morphology of the thoracic spinal cord was irregular and locally inflated. The patient was confirmed as VZV induced thoracic myelomyelitis by using the cerebrospinal fluid for metagenomic next-generation sequencing (mNGS). Conclusions mNGS may contribute to disease diagnosis for asymptomatic VZV infection-induced myelitis.

scholarly journals Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Phedias Diamandis ◽  
Ruben Ferrer-Luna ◽  
Raymond Y. Huang ◽  
Rebecca D. Folkerth ◽  
Azra H. Ligon ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Next Generation ◽  
Generation Sequencing

P034 Next generation sequencing - the ultimate tool for confirmatory HLA typing in cadaveric donors? A case report

2019 ◽  
Vol 80 ◽  
pp. 80
Author(s):  
Ibis T. Hernandez ◽  
Jennifer McCue ◽  
Ana Hernandez ◽  
Ozzarah Ferrer ◽  
Maria Reiger ◽  
...  
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Hla Typing ◽  
Next Generation ◽  
Cadaveric Donors ◽  
Generation Sequencing
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