Recent Applications of the Sentinel Lymph Node Concept: Preliminary Experience in Prostate Cancer

2002 ◽  
Vol 88 (3) ◽  
pp. S16-S17 ◽  
Author(s):  
M Rudoni ◽  
GM Sacchetti ◽  
L Leva ◽  
E Inglese ◽  
G Monesi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic Drainage ◽  
Pelvic Lymphadenectomy ◽  
Radioguided Surgery ◽  
Transrectal Biopsy ◽  
Duration Of Surgery ◽  
Sentinel Lymph Node Concept

Aims and Background Following the widespread use of radioguided surgery (RGS) in melanoma and breast cancer, we applied this new surgical strategy to prostate cancer (PC). The aims of this study were 1) to evaluate the accuracy of RGS in the detection of prostatic sentinel lymph nodes (SLN), and 2) to verify if pelvic lymphadenectomy (LAD) is an accurate means to detect solitary micrometastases. Study design We investigated 48 patients with PC confirmed by transrectal biopsy who underwent radical prostatectomy and bilateral LAD. A dose of 99mTc-labeled nanocolloid particles was injected into the prostate after needle positioning by ultrasonography. Serial imaging was obtained with a gamma camera, identifying 1) the first radioactive lymph node (sentinel lymph node, SLN); 2) other radioactive lymph nodes, and 3) non-active lymph nodes. Results Forty-three SLNs were identified in 48 patients. Twenty SLNs were located at unusual sites with respect to the extent of conventional LAD. Five SLNs were positive for micrometastases and two of these were located outside the usual LAD area. No micrometastases were found in any of the remaining lymph nodes (active and non-active). Conclusions These preliminary results are in agreement with the few previous scientific contributions available on this topic and indicate that it is possible to reduce the extent and duration of surgery and necessary to reevaluate the conventional sites of lymphatic drainage.

scholarly journals A First-in-Human Study of 68Ga-Nanocolloid PET/CT Sentinel Lymph Node Imaging in Prostate Cancer Demonstrates Aberrant Lymphatic Drainage Pathways

2018 ◽  
Vol 59 (12) ◽  
pp. 1837-1842 ◽  
Author(s):  
Jacki A. Doughton ◽  
Michael S. Hofman ◽  
Peter Eu ◽  
Rodney J. Hicks ◽  
Scott Williams
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Human Study ◽  
Lymphatic Drainage ◽  
Lymph Node Imaging ◽  
Pet Ct

Sentinel lymph node diagnostic in prostate carcinoma: Part I: Technique and clinical evaluation

2002 ◽  
Vol 41 (02) ◽  
pp. 95-101 ◽  
Author(s):  
F. Wawroschek ◽  
H. Wengenmair ◽  
T. Wagner ◽  
J. Kopp ◽  
R. Dorn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Probe ◽  
False Negative ◽  
Surgical Techniques ◽  
Pelvic Lymphadenectomy ◽  
Probe Measurement ◽  
Operation Theatre ◽  
Node Metastases

Summary Aim: Evaluation of the significance of lymphoscintigraphy and intraoperative probe measurement for the identification of the sentinel lymph node (SLN) in prostate cancer. Patients and method: In 117 patients with prostate cancer scintigrams in various projections were acquired till approximately 6 hours p.i. after ultrasound guided transrectal intraprostatic injection of 99mTc-Nanocoll ®. On the following day the SLNs were identified in the operation theatre with a gamma probe and removed. Pelvic standard lymph node dissection followed SLNE. Results: In three of 117 patients with preoperative lymphoscintigraphy no SLN was scintigraphically detectable. These three patients had antecedent transurethral resection of the prostate. In 113 of the residual 114 patients SLN could be intraoperatively localized. In the mean four SLNs per patient were removed. 28 of 117 patients had pelvic lymph node metastases. In 25 cases SLN were right-positive, in one false-negative and in one intraoperatively not detectable. In one patient we found macrometastasis of up to 4 cm diameter (one SLN was tumour positive). In 15 cases only the SLN was bearing tumour. Conclusion: The SLNE with preoperative lymphoscintigraphy and intraoperative gamma probe measurement is suitable for detecting lymph node metastasis in prostate cancer. SLNE is superior to the surgical techniques commonly used in pelvic lymphadenectomy.

scholarly journals Haute Couture or Ready-To-Wear? Tailored Pelvic Radiotherapy for Prostate Cancer Based on Individualized Sentinel Lymph Node Detection

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 944
Author(s):  
Anne-Victoire Michaud ◽  
Benoit Samain ◽  
Ludovic Ferrer ◽  
Vincent Fleury ◽  
Melanie Dore ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radiation Therapy Oncology Group ◽  
Significant Proportion ◽  
Lymphatic Drainage ◽  
Target Volume ◽  
Lymph Node Involvement ◽  
Pelvic Radiotherapy ◽  
Haute Couture

Prostate cancer (PCa) pelvic radiotherapy fields are defined by guidelines that do not consider individual variations in lymphatic drainage. We examined the feasibility of personalized sentinel lymph node (SLN)-based pelvic irradiation in PCa. Among a SLN study of 202 patients, we retrospectively selected 57 patients with a high risk of lymph node involvement. Each single SLN clinical target volume (CTV) was individually segmented and pelvic CTVs were contoured according to Radiation Therapy Oncology Group (RTOG) guidelines. We simulated a radiotherapy plan delivering 46 Gy and calculated the dose received by each SLN. Among a total of 332 abdominal SLNs, 305 pelvic SLNs (beyond the aortic bifurcation) were contoured (mean 5.4/patient). Based on standard guidelines, CTV missed 67 SLNs (22%), mostly at the common iliac level (40 SLNs). The mean distance between iliac vessels and the SLN was 11mm, and despite a 15mm margin around the iliac vessels, 9% of SLNs were not encompassed by the CTV. Moreover, 42 SLNs (63%) did not receive 95% of the prescribed dose. Despite a consensus on contouring guidelines, a significant proportion of SLNs were not included in the pelvic CTV and did not receive the prescribed dose. A tailored approach based on individual SLN detection would avoid underdosing pelvic lymph nodes that potentially contain tumor cells.

Sentinel lymph node in endometrial cancer

2007 ◽  
Vol 17 (5) ◽  
pp. 1113-1117 ◽  
Author(s):  
L.A.F Lopes ◽  
S. M Nicolau ◽  
F. F Baracat ◽  
E. C Baracat ◽  
W. J Gonçalves ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Endometrial Carcinoma ◽  
Frozen Section ◽  
False Negative ◽  
Pelvic Lymphadenectomy ◽  
Clinical Staging ◽  
Blue Dye

The aim of this study was to evaluate the possibility of identifying the sentinel lymph node and involvement of neoplastic cells in patients with endometrial carcinoma limited to the uterus, and also its correlation with the conditions of other pelvic and para-aortic lymph nodes. Forty patients with endometrial carcinoma, clinical staging I and II, were submitted to complete surgical staging through laparotomy, as recommended by FIGO in 1988. The sentinel node was investigated using patent blue dye in the myometrial subserosa. The sentinel node was excised and submitted to frozen section examination of specimen, stained with hematoxylin and eosin (H&E). Afterward, selective bilateral para-aortic and pelvic lymphadenectomy, total hysterectomy with bilateral salpingo-oophorectomy were performed. The lymph nodes excised were examined by means of paraffin-embedded slices stained with H&E and of imunohistochemistry with antikeratin antibody AE1/AE3. The sentinel lymph node was identified in 77.5% of patients (31/40), and 16.1% (5/31) presented neoplastic involvement in the node. In 25 cases of negative sentinel node, 96% (24/25) had no neoplastic involvement, and 4% (1/25) had other lymph node affected (false negative). In nine cases with no sentinel node identified, 55.5% (5/9) had lymph node involvement. The results of this study allow us to conclude that it is possible to identify the sentinel node using the methods described, and the pathologic examination significantly represents the same conditions of other pelvic and para-aortic lymph nodes.

The Sentinel Lymph Node Concept in Prostate Cancer – First Results of Gamma Probe-Guided Sentinel Lymph Node Identification

1999 ◽  
Vol 36 (6) ◽  
pp. 595-600 ◽  
Author(s):  
Friedhelm Wawroschek ◽  
Harry Vogt ◽  
Dorothea Weckermann ◽  
Theodor Wagner ◽  
Rolf Harzmann
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Probe ◽  
Sentinel Lymph Node Identification ◽  
First Results ◽  
Sentinel Lymph Node Concept

scholarly journals 1389: The Sentinel Lymph Node Concept in Prostate Cancer: Experiences after more than 6 Years

2006 ◽  
Vol 175 (4S) ◽  
pp. 448-448 ◽  
Author(s):  
Dorothea Weckermann ◽  
Robert Dorn ◽  
Eckart Gronau ◽  
Theodor Wagner ◽  
Rolf Harzmann
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Concept

scholarly journals THE SENTINEL LYMPH NODE CONCEPT IN IA2–IIA2 STAGES CERVICAL CANCER: CLINICAL PERSPECTIVES

2018 ◽  
Vol 14 (2) ◽  
pp. 90-95
Author(s):  
A. I. Berishvili ◽  
T. M. Kochoyan ◽  
N. V. Levkina ◽  
O. V. Li
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Surgical Treatment ◽  
Sentinel Lymph Node ◽  
Standard Treatment ◽  
Pelvic Lymphadenectomy ◽  
Female Population ◽  
Sentinel Node Concept ◽  
Reduce Risk ◽  
Sentinel Lymph Node Concept

Cervical cancer is currently the second most common form of neoplasia worldwide and third in the female population. The standard surgical treatment, for stages IA2-IIA, is radical hysterectomy with pelvic lymphadenectomy. The risk of intraoperative (vessel or nerve damage) or postoperative complications (lymphedema) is high. The sentinel node concept can reduce risk of such complications but currently is not included in the standard treatment.

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