Distinctive Peripheral Lymph Node Hyperplasia of Young Cats

1986 ◽  
Vol 23 (4) ◽  
pp. 386-391 ◽  
Author(s):  
F. M. Moore ◽  
W. E. Emerson ◽  
S. M. Cotter ◽  
R. A. DeLellis
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Plasma Cells ◽  
Leukemia Virus ◽  
Subsequent Development ◽  
Lymph Node Biopsy ◽  
Feline Leukemia Virus ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Hyperplasia

Peripheral lymph node enlargement was found in 14 of a series of 132 feline lymph node biopsy specimens. Six of nine cats tested had antibodies for feline leukemia virus (FeLV). Half of the cats were clinically normal while the remainder had fever, lethargy, anorexia, and hepatosplenomegaly. There was severe distortion of lymph nodal architecture with variable loss of discernible follicles and sinuses. Histiocytes, lymphocytes, immunoblasts, and plasma cells were present in expanded paracortical regions which encroached on, and occasionally effaced, lymphoid follicles. Postcapillary venules were numerous and prominent throughout the paracortex. The lymphadenopathy was most commonly transient (86% of cases) with subsequent development of lymphoma in one cat. Lymph nodes from seven kittens with experimental FeLV infection were compared with spontaneously enlarged lymph nodes; four of seven had B and T lymphocyte hyperplasia with normal nodal architecture. Three had partial loss of nodal architecture as a result of expanded paracortical regions populated largely by histiocytes and lymphocytes. Proliferation of postcapillary venules was not prominent in nodes from FeLV-infected cats. The cause of spontaneous lymph node hyperplasia of young cats was not determined. However, the similarity of lesions to those of kittens with experimental FeLV infection and the association with FeLV by serologic tests in six of nine cats suggest that this retrovirus may be involved in the pathogenesis of the lesion.

scholarly journals Peripheral lymph node helper T-cell recovery after syngeneic bone marrow transplantation in mice prepared with either gamma-irradiation or busulfan

Blood ◽  
1989 ◽  
Vol 74 (4) ◽  
pp. 1436-1445 ◽  
Author(s):  
WE Samlowski ◽  
BA Araneo ◽  
MO Butler ◽  
MC Fung ◽  
HM Johnson
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Lymph Nodes ◽  
Gamma Irradiation ◽  
Peripheral Lymph Node ◽  
Helper T Cell ◽  
Peripheral Lymph ◽  
Preparative Regimen

The optimum marrow ablative regimen for preparing recipients of bone marrow transplantation (BMT) has not been established. gamma- Irradiation, but not busulfan, produces a characteristic microvascular injury pattern which results in depressed capacity of normal lymphocytes to localize into the lymph nodes of syngeneic murine BMT recipients. Since peripheral lymph nodes are important sites for initiation and amplification of immune responses, the preparative regimen might delay recovery of regionally compartmentalized immune functions after BMT. We evaluated the effects of busulfan and gamma- irradiation on the phenotypic and functional reconstitution of helper T- cell function within the peripheral lymph nodes of BMT recipients. Both marrow ablative regimens caused a protracted delay in regeneration of peripheral lymph node CD4+ T cells. Specific helper T-cell functions, such as contact hypersensitivity and alloantigen responses, remained significantly depressed in the lymph nodes of irradiated mice for prolonged periods (up to 60 weeks). These responses recovered more rapidly in busulfan-treated BMT recipients. In contrast, the capacity of peripheral lymph node T cells to provide “help” for antigen-specific immunoglobulin production was only transiently depressed by either preparative regimen. Our experiments confirm the hypothesis that the marrow ablative regimen, particularly gamma-irradiation, may contribute to the period of immunodeficiency which follows BMT. The pattern of immune recovery observed suggests that preparative total body irradiation (TBI) may selectively depress the regional recovery of the TH1 [interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) secreting] lymphocyte subset.

Whipple's disease: an unexpected finding in a peripheral lymph node biopsy

The Lancet ◽  
2014 ◽  
Vol 383 (9936) ◽  
pp. 2268 ◽  
Author(s):  
Sarah Walters ◽  
Talal Valliani ◽  
Robert Przemioslo ◽  
Nicholas Rooney
Keyword(s):  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Unexpected Finding ◽  
Whipple’S Disease ◽  
Peripheral Lymph Node ◽  
Whipple's Disease ◽  
Node Biopsy ◽  
Peripheral Lymph

scholarly journals Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases

2007 ◽  
Vol 14 (4) ◽  
pp. 209-211 ◽  
Author(s):  
Halil Yanardag ◽  
Metin Caner ◽  
Irfan Papila ◽  
Sedat Uygun ◽  
Sabriye Demirci ◽  
...  
Keyword(s):  
Lymph Node ◽  
Low Cost ◽  
High Sensitivity ◽  
Practical Method ◽  
Diagnostic Value ◽  
Lymph Node Biopsy ◽  
Peripheral Lymph Node ◽  
Node Biopsy ◽  
Complication Risk ◽  
Peripheral Lymph

A peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five patients had a reactive adenopathy. For patients with histological diagnosis of sarcoidosis, localizations of the biopsies were as follows: cervical (n=21), supra-clavicular (n=20), inguinal (n=11), axillary (n=8), epitrochlear (n=5) and submandibular (n=2). At the time of biopsy, 12 patients had stage 0 disease, 37 patients had stage I disease, 14 patients had stage II disease and four patients had stage III disease. Skin involvement (16.4%) was the most frequently observed type of organ involvement in patients who had enlarged PLNs due to sarcoidosis. In the presence of an enlarged PLN in sarcoidosis, biopsy had a greater diagnostic value compared with other methods, as well as having a relatively low cost (approximately US$120) in Turkey. No procedure-related complications were observed. In conclusion, it is recommended that PLNs be thoroughly examined when sarcoidosis is suspected. If an enlarged PLN is found, biopsy should be routinely performed because it is an easy, convenient and practical method, with a low complication risk and a high sensitivity.

scholarly journals Peripheral lymph node helper T-cell recovery after syngeneic bone marrow transplantation in mice prepared with either gamma-irradiation or busulfan

Blood ◽  
1989 ◽  
Vol 74 (4) ◽  
pp. 1436-1445 ◽  
Author(s):  
WE Samlowski ◽  
BA Araneo ◽  
MO Butler ◽  
MC Fung ◽  
HM Johnson
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Lymph Nodes ◽  
Gamma Irradiation ◽  
Peripheral Lymph Node ◽  
Helper T Cell ◽  
Peripheral Lymph ◽  
Preparative Regimen

Abstract The optimum marrow ablative regimen for preparing recipients of bone marrow transplantation (BMT) has not been established. gamma- Irradiation, but not busulfan, produces a characteristic microvascular injury pattern which results in depressed capacity of normal lymphocytes to localize into the lymph nodes of syngeneic murine BMT recipients. Since peripheral lymph nodes are important sites for initiation and amplification of immune responses, the preparative regimen might delay recovery of regionally compartmentalized immune functions after BMT. We evaluated the effects of busulfan and gamma- irradiation on the phenotypic and functional reconstitution of helper T- cell function within the peripheral lymph nodes of BMT recipients. Both marrow ablative regimens caused a protracted delay in regeneration of peripheral lymph node CD4+ T cells. Specific helper T-cell functions, such as contact hypersensitivity and alloantigen responses, remained significantly depressed in the lymph nodes of irradiated mice for prolonged periods (up to 60 weeks). These responses recovered more rapidly in busulfan-treated BMT recipients. In contrast, the capacity of peripheral lymph node T cells to provide “help” for antigen-specific immunoglobulin production was only transiently depressed by either preparative regimen. Our experiments confirm the hypothesis that the marrow ablative regimen, particularly gamma-irradiation, may contribute to the period of immunodeficiency which follows BMT. The pattern of immune recovery observed suggests that preparative total body irradiation (TBI) may selectively depress the regional recovery of the TH1 [interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) secreting] lymphocyte subset.

scholarly journals Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.

1988 ◽  
Vol 107 (5) ◽  
pp. 1853-1862 ◽  
Author(s):  
P R Streeter ◽  
B T Rouse ◽  
E C Butcher
Keyword(s):  
Endothelial Cells ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Peyer's Patches ◽  
Peripheral Lymph Node ◽  
Lymphocyte Homing ◽  
Tissue Specific ◽  
Peripheral Lymph

The tissue localization or "homing" of circulating lymphocytes is directed in part by specialized vessels that define sites of lymphocyte exit from the blood. In peripheral lymph nodes, mucosal lymphoid tissues (Peyer's patches and appendix), and sites of chronic inflammation, for example, lymphocytes leave the blood by adhering to and migrating between those endothelial cells lining postcapillary high endothelial venules (HEV). Functional analyses of lymphocyte interactions with HEV have shown the lymphocytes can discriminate between HEV in different tissues, indicating that HEV express tissue-specific determinants or address signals for lymphocyte recognition. We recently described such a tissue-specific "vascular addressin" that is selectively expressed by endothelial cells supporting lymphocyte extravasation into mucosal tissues and that appears to be required for mucosa-specific lymphocyte homing (Streeter, P. R., E. L. Berg, B. N. Rouse, R. F. Bargatze, and E. C. Butcher. 1988. Nature (Lond.). 331:41-46). Here we document the existence and tissue-specific distribution of a distinct HEV differentiation antigen. Defined by monoclonal antibody MECA-79, this antigen is expressed at high levels on the lumenal surface and in the cytoplasm of HEV in peripheral lymph nodes. By contrast, although MECA-79 stains many HEV in the mucosal Peyer's patches, expression in most cases is restricted to the perivascular or ablumenal aspect of these venules. In the small intestine lamina propria, a mucosa-associated site that supports the extravasation of lymphocytes, venules do not stain with MECA-79. Finally, we demonstrate that MECA-79 blocks binding of both normal lymphocytes and a peripheral lymph node-specific lymphoma to peripheral lymph node HEV in vitro and that it also inhibits normal lymphocyte homing to peripheral lymph nodes in vivo without significantly influencing lymphocyte interactions with Peyer's patch HEV in vitro or in vivo. Thus, MECA-79 defines a novel vascular addressin involved in directing lymphocyte homing to peripheral lymph nodes.

Orchidectomy and the immune response I. Effect of orchidectomy on lymphoid tissues of mice

1974 ◽  
Vol 185 (1081) ◽  
pp. 425-436 ◽  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphoid Tissues ◽  
Spleen Size ◽  
Thymic Involution ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Enlargement ◽  
Spleen Mass ◽  
Lymph Node Mass

The effects of pre- and postpuberal orchidectomy on the lymphoid tissues of mice have been studied. Prepuberal orchidectomy delayed the normal rate of thymic involution and caused relative hypertrophy of the thymus which was maximal 1 month after surgery. There was also enlargement of the peripheral lymph nodes to reach a sustained maximum by 6 weeks and also an increase of spleen size. Histological examination of the enlarged thymus showed widening of the cortex and medulla with increased cell density. The enlarged peripheral lymph nodes showed widening of the paracortical area which is thymus dependent. Synchronous thymectomy and orchidectomy prevented the lymph node enlargement that follows orchidectomy alone, but it did not affect the increase of spleen size until 3 months after surgery. After postpuberal orchidectomy thymic size increased to a maximum at 1 month and the increase of peripheral lymph node mass and spleen mass was less than the changes following prepuberal surgery ; only 3 months after operation was the lymph node mass of orchidectomized mice significantly greater than controls and changes in spleen mass were only apparent after correction for changes in body mass.

Diagnosis of Whipple's disease by peripheral lymph node biopsy

1959 ◽  
Vol 27 (2) ◽  
pp. 351-353 ◽  
Author(s):  
W.Crockett Chears ◽  
Albert G. Smith ◽  
Julian M. Ruffin
Keyword(s):  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Whipple’S Disease ◽  
Peripheral Lymph Node ◽  
Whipple's Disease ◽  
Node Biopsy ◽  
Peripheral Lymph

scholarly journals Peripheral Lymph Node Excisional Biopsy: Yield, Relevance, and Outcomes in a Remote Surgical Setup

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ashish Lal Shrestha ◽  
Pradita Shrestha
Keyword(s):  
Lymph Node ◽  
Diagnostic Yield ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Histopathological Diagnosis ◽  
Peripheral Lymph Node ◽  
Less Invasive ◽  
Patient Profile ◽  
Peripheral Lymph

Objective. To study the patient profile for symptomatic peripheral lymphadenopathy in terms of histopathological findings and demography and evaluate the yield, relevance, and outcomes of peripheral lymph node biopsy (PLNB) as a diagnostic step in a remote setup in the absence of less invasive options like fine-needle aspiration cytology (FNAC) or ultrasonogram- (USG-) guided FNAC. Methods. A retrospective review of patients undergoing PLNB between 1 May 2011 and 30 April 2013 was done. Demographics, histopathological reports, and outcomes were studied. Results. Of 132 patients, 51 (38.63%) were male and 81 (61.36%) were female. There were 48 (36.3%) patients in the age group less than 16 years, and 84 (63.6%) were beyond 16 years. The commonest site of biopsy was the neck in 114 (86.36%) patients. The histopathological diagnosis was tuberculosis (TB) in 60 (45.45%) patients, reactive lymphadenitis in 29 (21.9%), nonspecific granuloma in 18 (13.6%), lymphoma in 7 (5.3%), acute lymphadenitis in 7 (5.3%), metastatic secondary in 3 (2.2%), and other benign causes in 8 (6.06%). Conclusions. PLNB is a procedure with good diagnostic yield in evaluation of peripheral lymphadenopathy. Its relevance is appreciable in a remote setup where less invasive options are unavailable. Its simplicity and lack of mortality/significant morbidity make it a valid option in rural surgical practice.

scholarly journals Surgical peripheral lymph node biopsies in Makurdi, Nigeria.

2019 ◽  
Vol 6 (3) ◽  
pp. 75-78
Author(s):  
Barnabas Eke ◽  
Babarinde Ojo ◽  
Rymond Vhriterhire ◽  
Issac Akper ◽  
Victor Ugwu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Teaching Hospital ◽  
Diagnostic Yield ◽  
Lymph Node Biopsy ◽  
University Teaching ◽  
Axillary Lymph ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Enlargement ◽  
Common Causes

This study aims at determining the diagnostic value of peripheral lymph node biopsy and common causes of lymph node enlargement from biopsies obtained from patients with lymph-node enlargement at different sites in a teaching hospital in north central Nigeria town of Makurdi, Benue State. This is a retrospective study of surgical peripheral lymph node biopsies received in the department of Anatomic Pathology, Benue State University Teaching Hospital, Makurdi, Nigeria from February, 2012 to September, 2019. Total number of lymph node biopsies during the period was 47 representing 1.0% of surgical pathology specimens submitted to the department; 25 cases were females and 22 were males. Metastatic nodal involvement (57%), lymphoma (23%) and tuberculosis lymphadenitis (11%) were the most common causes of lymph node enlargement. All the studied nodes were localized. The most common sites of lymphadenopathy were axillary (21%), cervical (16%) and Inguinal (6%). While axillary lymph node enlargements were mostly associated with tumor metastasis, cervical and inguinal node enlargements were mostly associated with tuberculosis and lymphoma, respectively. Surgical excision of nodal enlargement for histological examination represents a simple, good diagnostic yield with lack of significant morbidity or mortality.

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