Canine Ovarian Neoplasms: A Clinicopathologic Study of 71 Cases, Including Histology of 12 Granulosa Cell Tumors

In a retrospective study of 71 primary ovarian tumors in the dog, epithelial tumors (46%) were more common than sex cord stromal (34%) and germ cell tumors (20%). There were more adenocarcinomas (64%) than adenomas. Sex cord stromal tumors were equally divided into Sertoli-Leydig (12/24) and granulosa cell tumors (12/24). There were equal numbers (7/14) of dysgerminomas and teratomas among the germ cell tumors. Most teratomas (6/7) were malignant. Most granulosa cell tumors were solid; two were mostly cystic. Patterns included sheets of round and ovoid to spindle-shaped cells separated by thin, fibrovascular stroma; neoplastic cells formed rosettes or Call-Exner bodies. In some areas, neoplastic cells were in cords or columns and formed cyst-like structures. Four granulosa cell tumors were macrofollicular, having cysts lined with granulosa cells. Median ages of dogs with different ovarian neoplasms were similar; all were more than 10 years old, except the dogs with teratoma (mean age, 4 years). Most neoplasms were unilateral (84%), except the Sertoli-Leydig cell tumors, many of which were bilateral (36%). Size of ovarian neoplasms varied (2 cm3 to 15,000 cm3). Twenty-nine percent of neoplasms metastasized; adenocarcinomas (48%) and malignant teratomas (50%) had the highest rates, and distant metastasis was more common in malignant teratoma. Endometrial hyperplasia was in 67% of the dogs; it was most common in dogs with sex cord stromal tumors (95%). Uterine malignancy was not seen in dogs with granulosa cell tumors, although hyperplastic endometrium was in all dogs with this tumor. Cysts in the contralateral ovaries were most common in dogs with sex cord stromal tumors.

Download Full-text

Feline Ovarian Neoplasms

Veterinary Pathology ◽

10.1177/030098588502200610 ◽

1985 ◽

Vol 22 (6) ◽

pp. 572-576 ◽

Cited By ~ 42

Author(s):

H. B. Gelberg ◽

K. McEntee

Keyword(s):

Germ Cell ◽

Granulosa Cell ◽

Clinical Evidence ◽

Ovarian Neoplasms ◽

Germ Cell Tumors ◽

Granulosa Cell Tumors ◽

Epithelial Origin

Primary ovarian neoplasms from 22 cats were described. A single cat had tumors of epithelial origin—bilateral cystadenomas. Seven animals had germ cell tumors—dysgerminomas or teratomas; two cats had bilateral tumors. Fourteen animals had neoplasms of sex cord-stromal origin—granulosa cell tumors and interstitial gland tumors. Four cats with granulosa cell tumors had clinical evidence of hormonal disturbance.

Download Full-text

Sex cord stromal and germ cell ovarian cancer: Is there a racial disparity?

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e18056 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e18056-e18056

Author(s):

Fatima Reyes ◽

Rosa Guerra ◽

Cheng-I Liao ◽

Chris Argueta ◽

Amandeep Kaur Mann ◽

...

Keyword(s):

Ovarian Cancer ◽

Germ Cell ◽

Granulosa Cell ◽

Germ Cell Tumor ◽

Germ Cell Tumors ◽

Immature Teratoma ◽

Cell Tumor ◽

Asian Women ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

e18056 Background: We proposed to determine the incidence and presentation of sex cord stromal and germ cell ovarian cancers in various racial groups. Methods: Data was obtained from the United States Cancer Statistics (USCS) and National Cancer Database (NCDB) databases between 2004 and 2016. Chi-squared tests were used for statistical analyses. Results: Of 8,917 women, 48.2% were diagnosed with sex cord stromal ovarian cancer, and 52.5% had germ cell ovarian cancer. White, Black, and Asian individuals comprised 72.5%, 19.8%, and 4.16% of the population, respectively. Of the sex cord stromal tumors, 84.1% were granulosa cell, 7.9% sertoli leydig, 1.8% steroid cell, and 6.2% "other" tumors. Of the germ cell tumors, 23.3% were immature teratoma, 19.6% dysgerminoma, 10.3% yolk sac, 8.3% mixed germ cell tumor, 0.1% embryonal carcinoma, and 38.3% "other" germ cell tumor histologies. Using the UCSC database, the age-adjusted incidence of sex cord stromal was 0.50 per 100,000 for Blacks compared to 0.23 for Whites and 0.14 for Asians. The incidence for germ cell tumors was 0.40 per 100,000 in Whites, 0.46 in Blacks, and 0.44 in Asians. Using NCDB data, the proportion of sex cord stromal tumor was 5.6% in Blacks compared to 1.5% in Whites and 1.55% in Asians, and the most common histology of sex cord stromal tumors was granulosa cell tumors in every racial group. The proportion of germ cell tumors was also higher in Blacks at 4.4% compared to 2.0% in Whites and 3.9% in Asians. Of germ cell tumors, the most common histology was dysgerminoma for Whites at 22.3% and immature teratoma in Blacks and Asians at 28.0% and 26.9%, respectively. Conclusions: Our data suggest that Black women are more likely to be diagnosed with sex cord stromal tumors compared to White and Asian women. Black and Asian women also had more germ cell cancer than White women.

Download Full-text

Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

Archives of Pathology & Laboratory Medicine ◽

10.5858/2009-0512-rsr.1 ◽

2011 ◽

Vol 135 (1) ◽

pp. 143-146 ◽

Cited By ~ 3

Author(s):

Joshua Anspach Hanson ◽

Abiy B. Ambaye

Keyword(s):

Granulosa Cell ◽

Case Reports ◽

Granulosa Cell Tumor ◽

Malignant Potential ◽

Cell Tumor ◽

Review Of The Literature ◽

Stromal Tumors ◽

Granulosa Cell Tumors ◽

Pathologic Features ◽

Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

Download Full-text

Non-Epithelial Ovarian Cancer; NCI Study

Tumori Journal ◽

10.1177/0300891620914127 ◽

2020 ◽

Vol 106 (1_suppl) ◽

pp. 7-7

Author(s):

Ashraf Sobhy ◽

Mohammed Gamil ◽

Omar Youssef ◽

Ali Hassan Mebed

Keyword(s):

Ovarian Cancer ◽

Germ Cell ◽

Epithelial Ovarian Cancer ◽

Germ Cell Tumors ◽

Disease Stage ◽

Early Stage Disease ◽

Stromal Tumors ◽

Ovarian Cancers ◽

Malignant Germ Cell Tumors ◽

Sex Cord Stromal Tumors

Background: Non-epithelial cancers of the ovary are uncommon. They include malignancies of germ cell origin, sex cord-stromal cell origin, metastatic carcinomas to the ovary, and a variety of extremely rare ovarian cancers, such as sarcomas and lipoid cell tumors. Nonepithelial malignancies account for about 10% of all ovarian cancers. Objective: To review the management of Non-epithelial ovarian cancer in the NCI Cairo university during a period of 5 years (2005 till 2010). Material and Methods: Retrospective study including 114 patients who were diagnosed and treated with Non-epithelial ovarian cancer (2005 to 2010). Data were collected from the biostatistics and cancer epidemiology department. Results: Out of 114 patients; 25(21.9%) were benign and 25 (21.9%) were borderline malignant; 55 (48.2%) were malignant and 9 (7.89%) of them were unpredicted biologic behavior; the median age of the study population was 49.7 years (range 14_83years). Panhysterectomy was done in 77(67.5%) of the patients; ovariectomy and debulking were done in 22(19.3%; salpingooophorectomy was done in 10(8.8%) 0f patients and cystectomy was done in 3(2.6%) and 2 cases underwent biopsy. Conclusion: Sex cord-stromal tumors and malignant germ cell tumors are the most common nonepithelial ovarian cancers. These tumors often, but not always, present with the sequelae of overproduction of either androgens or estrogens. It is important to diagnose these masses early, as overall prognosis is typically very good for early stage disease in all histological subtypes. Both sex cord-stromal tumors and malignant germ cell tumors of the ovary are treated with initial surgical resection. Fertility sparing surgery can be considered for both sex cord-stromal and malignant germ cell tumors of the ovary. Depending on the pathological diagnosis and disease stage, postoperative management consists of either expectant management or adjuvant chemotherapy. It is recommended that all patients with nonepithelial ovarian cancer be monitored for evidence of disease recurrence on a standardized schedule.

Download Full-text

Germ Cell Tumors and Mixed Germ Cell-Sex Cord-Stromal Tumors of the Ovary

Gynecologic and Obstetric Pathology, Volume 2 ◽

10.1007/978-981-13-3019-3_8 ◽

2019 ◽

pp. 231-271 ◽

Cited By ~ 1

Author(s):

Hao Chen ◽

Charles Matthew Quick ◽

Oluwole Fadare ◽

Wenxin Zheng

Keyword(s):

Germ Cell ◽

Germ Cell Tumors ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

Download Full-text

Malignant germ cell tumors and sex cord-stromal tumors in adults and children

Altchek's Diagnosis and Management of Ovarian Disorders ◽

10.1017/cbo9781139003254.029 ◽

2013 ◽

pp. 431-442

Author(s):

Jubilee Brown ◽

David M. Gershenson

Keyword(s):

Germ Cell ◽

Germ Cell Tumors ◽

Stromal Tumors ◽

Adults And Children ◽

Malignant Germ Cell Tumors ◽

Sex Cord Stromal Tumors

Download Full-text

Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_117_18 ◽

2019 ◽

Vol 11 (01) ◽

pp. 075-081 ◽

Cited By ~ 1

Author(s):

Neha Gupta ◽

Mahima Yadav ◽

Vikas Gupta ◽

Deepshikha Chaudhary ◽

Shashikant C. U. Patne

Keyword(s):

Germ Cell ◽

Who Classification ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Germ Cell Tumors ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Care Hospital ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

Abstract BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

Download Full-text

“Chronic fatigue, quality of life and long-term side-effects of chemotherapy in patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors”

BMC Cancer ◽

10.1186/s12885-021-08864-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

François Gernier ◽

Djihane Ahmed-Lecheheb ◽

Patricia Pautier ◽

Anne Floquet ◽

Cédric Nadeau ◽

...

Keyword(s):

Quality Of Life ◽

Ovarian Cancer ◽

Side Effects ◽

Germ Cell ◽

Germ Cell Tumors ◽

Chronic Fatigue ◽

Stromal Tumors ◽

Sex Cord Stromal Tumors

Abstract Background Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surgery combined with chemotherapy [bleomycin, etoposide and cisplatin (BEP)] depending on the stage and the prognostic factors, as for testicular cancers. As reported in testicular cancer survivors, chemotherapy may induce sequelae impacting quality of life, which has not yet been evaluated in survivors of germ cell tumors and sex cord stromal tumors. The GINECO-VIVROVAIRE-Rare tumor study is a two-step investigation aiming to assess i) chronic fatigue and quality of life and ii) long-term side-effects of chemotherapy with a focus on cardiovascular and pulmonary disorders. Methods Using self-reported questionnaires, chronic fatigue and quality of life are compared between 134 ovarian cancer survivors (cancer-free ≥2 years after treatment) treated with surgery and chemotherapy and 2 control groups (67 ovarian cancer survivors treated with surgery alone and 67 age-matched healthy women). Medical data are collected from patient records. In the second step evaluating the long-term side-effects of chemotherapy, a subgroup of 90 patients treated with chemotherapy and 45 controls undergo the following work-up: cardiovascular evaluation (clinical examination, non-invasive cardiovascular tests to explore heart disease, blood tests), pulmonary function testing, audiogram, metabolic and hormonal blood tests. Costs of sequelae will be also assessed. Patients are selected from the registry of the INCa French Network for Rare Malignant Ovarian Tumors, and healthy women by the ‘Seintinelles’ connected network (collaborative research platform). Discussion This study will provide important data on the potential long-term physical side-effects of chemotherapy in survivors of Germ Cell Tumors (GCT) and Sex Cord Stromal Tumors (SCST), especially cardiovascular and pulmonary disorders, and neurotoxicity. The identification of long-term side-effects can contribute to adjusting the treatment of ovarian GCT or SCST patients and to managing follow-up with adapted recommendations regarding practices and chemotherapy regimens, in order to reduce toxicity while maintaining efficacy. Based on the results, intervention strategies could be proposed to improve the management of these patients during their treatment and in the long term. Trial registration This trial was registered at clinicaltrials.gov: 03418844, on 1 February 2018. This trial was registered on 25 October 2017 under the unique European identification number (ID-RCB): 2017-A03028–45. Recruitment Status: Recruiting. Protocol version Version n° 4.2 dated from Feb 19, 2021. Trial sponsor Centre François Baclesse, 3 avenue du Général Harris, F-14076 Caen cedex 05, France.

Download Full-text