scholarly journals Comparison of Actual Tidal Volume in Neonatal Lung Model Volume Control Ventilation using Three Ventilators

2010 ◽  
Vol 38 (4) ◽  
pp. 599-606
Author(s):  
H. Toyama ◽  
Y. Endo ◽  
Y. Ejima ◽  
M. Matsubara ◽  
S. Kurosawa
Keyword(s):  
Tidal Volume ◽  
Control Ventilation ◽  
Lung Model ◽  
Volume Control ◽  
Volume Control Ventilation ◽  
Neonatal Lung

Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice

2004 ◽  
Vol 287 (5) ◽  
pp. L902-L910 ◽  
Author(s):  
Sharmila Choudhury ◽  
Michael R. Wilson ◽  
Michael E. Goddard ◽  
Kieran P. O'Dea ◽  
Masao Takata
Keyword(s):  
Lung Injury ◽  
Tidal Volume ◽  
Molecular Mechanisms ◽  
Control Ventilation ◽  
Volume Control ◽  
Neutrophil Sequestration ◽  
Ventilator Induced Lung Injury ◽  
Volume Control Ventilation

Polymorphonuclear leukocytes (PMN) play an important role in ventilator-induced lung injury (VILI), but the mechanisms of pulmonary PMN recruitment, particularly early intravascular PMN sequestration during VILI, have not been elucidated. We investigated the physiological and molecular mechanisms of pulmonary PMN sequestration in an in vivo mouse model of VILI. Anesthetized C57/BL6 mice were ventilated for 1 h with high tidal volume (injurious ventilation), low tidal volume and high positive end-expiratory pressure (protective ventilation), or normal tidal volume (control ventilation). Pulmonary PMN sequestration analyzed by flow cytometry of lung cell suspensions was substantially enhanced in injurious ventilation compared with protective and control ventilation, preceding development of physiological signs of lung injury. Anesthetized, spontaneously breathing mice with continuous positive airway pressure demonstrated that raised alveolar pressure alone does not induce PMN entrapment. In vitro leukocyte deformability assay indicated stiffening of circulating leukocytes in injurious ventilation compared with control ventilation. PMN sequestration in injurious ventilation was markedly inhibited by administration of anti-L-selectin antibody, but not by anti-CD18 antibody. These results suggest that mechanical ventilatory stress initiates pulmonary PMN sequestration early in the course of VILI, and this phenomenon is associated with stretch-induced inflammatory events leading to PMN stiffening and mediated by L-selectin-dependent but CD18-independent mechanisms.

scholarly journals The Effect of Volume Controlled and Pressure Controlled Ventilation Modes on Cerebral Oximetry and Blood Gas Status in Laparoscopic Cholecystectomy, A Randomized Controlled Trial

2021 ◽  
Author(s):  
Emre Badur ◽  
Mustafa Altınay ◽  
Pınar Sayın ◽  
Ayşe Surhan Çınar ◽  
leyla türkoğlu ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Pressure Control ◽  
Control Ventilation ◽  
Cerebral Oximetry ◽  
Volume Control ◽  
Pressure Control Ventilation ◽  
Ventilation Mode ◽  
Group V ◽  
Volume Control Ventilation ◽  
Ventilation Modes

Abstract Background: To compare the volume-controlled and pressure-controlled ventilation modes with near infrared spectroscopy (NIRS) cerebral oximetry and blood gas status in laparoscopic cholecystectomyMethods: Seventy patients (n=70), who underwent elective laparoscopic cholecystectomy operation were randomized into two groups (volume control ventilation - group V, pressure control ventilation - group P). Demographic data (age, gender, body mass index) and operative data (anesthesia, surgery, and insufflation durations) were recorded. Patients’ single derivation electrocardiogram, pulse oximetry, non-invasive arterial pressure, NIRS cerebral oximetry and end-tidal CO2 parameters were recorded. Measurements were done at the start of anesthesia (T0), at the end of intubation (T1), 5 minutes after the insufflation (T2), at the time just before desufflation (T3) and 5 minutes after desufflation (T4).The patients’ heart rate, systolic and diastolic arterial pressure, saturation of pulse oximetry, and NIRS values were recorded for time points. Additionally, arterial gas results and mechanical ventilation parameters were recorded as well. Results: No significant difference was found in age, sex, body mass index. Operation, anesthesia and insufflation durations were similar for the groups. In Group P, NIRS right T1-2-3 averages and NIRS left T2-3 averages were significantly higher than Group V (p=0.030, p=0.001, p=0.001, p=0.006, p=0.002 respectively). In Group P T1-T2-T4, mean peak pressures and mean plateau pressures were significantly lower than Group V (p=0.003, p=0.001, p<0.001, p=0.011, p=0.001, p<0.001 respectively).Conclusion: Mechanical ventilation that performed in pressure-control ventilation mode is resulted with better tissue oxygenation than volume-control ventilation mode. In pressure-control ventilation mode, peak pressure and plateau pressure were lower.Registration of study at ClinicalTrials.gov was made at 25/01/2021 with the NCT04723043 number.

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