Triggerless neuralgic otalgia: A case series and systematic literature review

Cephalalgia ◽  
2013 ◽  
Vol 33 (11) ◽  
pp. 914-923 ◽  
Author(s):  
Jonathan H Smith ◽  
Carrie E Robertson ◽  
Ivan Garza ◽  
F Michael Cutrer

Background Isolated neuralgic pain in the deep ear may arise from either nervus intermedius (NIN) or glossopharyngeal (GPN) neuralgias. Current International Headache Society (IHS) International Classification of Headache Disorders, second edition (ICHD-2) criteria for these cranial neuralgias require the presence of a characteristic trigger. Aim The aim of this article is to report cases of triggerless neuralgic otalgia to better understand a subset of patients for whom there may be diagnostic uncertainty. Methods Methods included an observational cohort series and systematic literature review. Results We identified five female patients with a median age at symptom onset of 58 (range: 47 to 73). Our patients generally experienced an excellent clinical response to carbamazepine. Patients were contacted by telephone at a median follow-up duration of seven years (range: four to 32) from symptom onset, at which time carbamazepine-free remissions were reported by five of five (100%) of the patients. A systematic review of the literature on neuralgic otalgia led us to conclude that NIN was most common among young women (age < 50), and GPN across a wider range of ages of either gender. Among surgically validated cases reported in the literature, triggers were frequently absent in NIN, and variably noted in GPN. Conclusions We conclude that the presence of a trigger is not fundamental, and may be impractical, to the diagnosis of neuralgic otalgia, but remains important for specificity between NIN and GPN.

2021 ◽  
pp. 1-7
Author(s):  
Julia Velz ◽  
Marian Christoph Neidert ◽  
Yang Yang ◽  
Kevin Akeret ◽  
Peter Nakaji ◽  
...  

<b><i>Objective:</i></b> Brainstem cavernous malformations (BSCM)-associated mortality has been reported up to 20% in patients managed conservatively, whereas postoperative mortality rates range from 0 to 1.9%. Our aim was to analyze the actual risk and causes of BSCM-associated mortality in patients managed conservatively and surgically based on our own patient cohort and a systematic literature review. <b><i>Methods:</i></b> Observational, retrospective single-center study encompassing all patients with BSCM that presented to our institution between 2006 and 2018. In addition, a systematic review was performed on all studies encompassing patients with BSCM managed conservatively and surgically. <b><i>Results:</i></b> Of 118 patients, 54 were treated conservatively (961.0 person years follow-up in total). No BSCM-associated mortality was observed in our conservatively as well as surgically managed patient cohort. Our systematic literature review and analysis revealed an overall BSCM-associated mortality rate of 2.3% (95% CI: 1.6–3.3) in 22 studies comprising 1,251 patients managed conservatively and of 1.3% (95% CI: 0.9–1.7) in 99 studies comprising 3,275 patients with BSCM treated surgically. <b><i>Conclusion:</i></b> The BSCM-associated mortality rate in patients managed conservatively is almost as low as in patients treated surgically and much lower than in frequently cited reports, most probably due to the good selection nowadays in regard to surgery.


2016 ◽  
Vol 10 (6) ◽  
pp. 990-1011 ◽  
Author(s):  
Judith A. Meiklejohn ◽  
Alexander Mimery ◽  
Jennifer H. Martin ◽  
Ross Bailie ◽  
Gail Garvey ◽  
...  

2019 ◽  
Vol 38 (1) ◽  
pp. 113-137
Author(s):  
Tsvetanka Georgieva-Trifonova ◽  
Kaloyan Zdravkov ◽  
Donika Valcheva

Purpose The purpose of this paper is to summarize the current state of the existing research on the application of semantic technologies in bibliographic databases by providing answers to a set of research questions resulting from a systematic literature review. Design/methodology/approach The present study consists of conducting a systematic literature review of research works related to the application of semantic technologies in bibliographic databases. A manual keyword search is performed in known academic databases. As a result, a total of 78 literature sources are identified as related to the topic and included in the review. From the selected literature sources, information is extracted, which is then summarized and analyzed according to previously defined research questions and finally reported. Besides, a framework is defined to classify literature sources found and collected as a result of the study. The main criteria, according to which the classification is performed, are the used semantic technology and the research problem for which semantic technologies are applied in bibliographic databases. The classification of the publications is verified by each author independently of others. Findings The conducted systematic scientific review establishes that the evolution of semantic technologies sets a period of increased interest in the researchers, as a result of which the advantages of using them for bibliographic descriptions are examined and practically confirmed. After defining semantic models for bibliographic descriptions and approaches to transform existing bibliographic data into their correspondence, the research interest is directed at their comparison, collation; enrichment to facilitate search and retrieval of useful information. Possible perspectives for future research are outlined, which mainly relate to the complete use of the created data sets and their transformation into knowledge repositories. Originality/value Despite the increasing importance of the semantic technologies in various areas, including the bibliographic databases, there is a lack of comprehensive literature review and classification of literature sources relevant to this topic. The detailed study proposed in the present paper supports introducing with the existing experience in the application of semantic technologies in bibliographic databases, as well as facilitates the discovery of trends and guidelines for future research.


2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 1076.2-1076 ◽  
Author(s):  
A. Ogdie ◽  
W. Taylor ◽  
M. Weatherall ◽  
J. Fransen ◽  
T. Jansen ◽  
...  

2021 ◽  
pp. 1-8
Author(s):  
Jonathan Rychen ◽  
Adrian Madarasz ◽  
Michael Murek ◽  
Philippe Schucht ◽  
Mirjam R. Heldner ◽  
...  

OBJECTIVE Postoperative internal carotid artery (ICA) intimal flap (IF) is a potential complication after carotid endarterectomy (CEA) for carotid artery stenosis. There are no clear recommendations in the current literature on the management of this condition due to sparse evidence. Some authors advocate carotid stent placement or reoperation, while others suggest watchful waiting. The aim of this study was to analyze incidence and management strategies of postoperative ICA-IF, and moreover, to put these findings into context with a systematic literature review. METHODS The authors retrospectively reviewed all consecutive CEA cases performed at the University Hospital of Bern over a decade (January 2008 to December 2018). The incidence of postoperative ICA-IF, risk factors, management strategies, and outcomes were analyzed. These results were put into context with a systematic review following the PRISMA guidelines. RESULTS A total of 725 CEAs were performed between January 2008 and December 2018. Postoperative ICA-IF was detected by routine duplex neurovascular ultrasound (NVUS) in 13 patients, corresponding to an incidence rate of 1.8% (95% CI 1.0%–3.1%). There were no associated intraluminal thrombi on the detected IF. Intraoperative shunt placement was used in 5.6% and one or more intima tack sutures were performed in 42.5% of the 725 cases. There was no significant association between intraoperative shunt placement and the occurrence of an IF (p > 0.99). Two patients (15.4%) with IF experienced a transient postoperative neurological deficit (transient ischemic attack). In these cases, the symptoms resolved spontaneously without any interventions or change in the antiplatelet regimen. All other cases (84.6%) with IF were asymptomatic. In 1 patient (7.7%) with IF, the antiplatelet treatment was switched from a mono- to a dual-antiaggregating regimen because the IF led to a stenosis > 70%; this patient remained asymptomatic. All cases of IFs were managed conservatively with close radiological follow-up evaluations, without reoperation or stenting of the ICA. All 13 IFs vanished spontaneously after a mean duration of 6.9 months (median 1.5 months, range 0.5–48 months). A systematic literature review revealed a postoperative ICA-IF incidence of 3.0% (95% CI 2.1%–4.1%) with relatively heterogenous management strategies. CONCLUSIONS Postoperative ICA-IF is a rare finding after CEA. Conservative therapy with close NVUS follow-up evaluations appears to be an acceptable and safe management strategy for asymptomatic IFs without associated intraluminal thrombi.


Author(s):  
Cigdem Gonul Kochan ◽  
David R. Nowicki

PurposeThe study of supply chain resilience (SCRES) continues to gain interest in the academic and practitioner communities. The purpose of this paper is to present a focused review of the SCRES literature by investigating supply chain (SC) capabilities, their relationship to SCRES outcomes and the underpinning theoretical mechanisms of this relationship.Design/methodology/approachThe paper uses the systematic literature review approach to examine 383 articles published between 2000 and 2017, ultimately down selecting to the most relevant 228 peer-reviewed studies. Context-interventions-mechanisms-outcomes (CIMO) logic is applied to organize and synthesize these peer-reviewed studies. A typological framework is developed from the CIMO-based classification of the SCRES literature.FindingsThe findings of this study outline the gaps in the SCRES literature and present an agenda for future research.Research limitations/implicationsThis paper presents an exploratory research; therefore, the typological model presented is just one of the possible perspectives.Practical implicationsThe typology of SCRES literature can help practitioners to understand SCRES and to measure and assess the resilience of SCs.Originality/valueThe paper provides clear definitions of SCRES constructs, develops a typological framework to further understand SCRES and identifies SCRES measures and assessment techniques.


Informatics ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 32 ◽  
Author(s):  
Alessandra Antonaci ◽  
Roland Klemke ◽  
Marcus Specht

Gamification has recently been presented as a successful strategy to engage users, with potential for online education. However, while the number of publications on gamification has been increasing in recent years, a classification of its empirical effects is still missing. We present a systematic literature review conducted with the purpose of closing this gap by clarifying what effects gamification generates on users’ behaviour in online learning. Based on the studies analysed, the game elements most used in the literature are identified and mapped with the effects they produced on learners. Furthermore, we cluster these empirical effects of gamification into six areas: performance, motivation, engagement, attitude towards gamification, collaboration, and social awareness. The findings of our systematic literature review point out that gamification and its application in online learning and in particular in Massive Online Open Courses (MOOCs) are still a young field, lacking in empirical experiments and evidence with a tendency of using gamification mainly as external rewards. Based on these results, important considerations for the gamification design of MOOCs are drawn.


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