Decreased levels of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension

Cephalalgia ◽  
2016 ◽  
Vol 36 (14) ◽  
pp. 1379-1384 ◽  
Author(s):  
Kathrin Doppler ◽  
Morten Schütt ◽  
Claudia Sommer
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Binding Protein ◽  
Aquaporin 4 ◽  
Retinol Binding Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Increased Intracranial Pressure ◽  
Retinol Binding Protein 4

Background Idiopathic intracranial hypertension is characterized by increased intracranial pressure. Its pathogenesis is largely unknown. Aquaporins may play a role in the homeostasis of cerebrospinal fluid. Methods We aimed to elucidate the role of aquaporins in idiopathic intracranial hypertension by measuring the level of aquaporin-1 and aquaporin-4 in the cerebrospinal fluid and plasma of 28 patients and 29 controls by enzyme-linked immunosorbent assay. The adipokines leptin and retinol-binding protein 4 were also measured. Results We found a reduction in aquaporin-4 in the cerebrospinal fluid of patients. Leptin levels were increased in the cerebrospinal fluid and plasma of patients and were correlated with weight, body mass index and body fat. There was no difference between patients and controls in the levels of aquaporin-4 and retinol-binding protein 4. Conclusion Our data suggest that an imbalance of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension may contribute to the pathogenesis of this disorder.

Retinol-Binding Protein and Retinol Analysis in Cerebrospinal Fluid and Serum of Patients With and Without Idiopathic Intracranial Hypertension

2007 ◽  
Vol 27 (4) ◽  
pp. 258-262 ◽  
Author(s):  
Judith E. A Warner ◽  
Alexander J Larson ◽  
Prakash Bhosale ◽  
Kathleen B Digre ◽  
Courtney Henley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Binding Protein ◽  
Retinol Binding Protein

Dietary Vitamin A and Visceral Adiposity: A Modulating Role of the Retinol-Binding Protein 4 Gene

2015 ◽  
Vol 8 (4-6) ◽  
pp. 164-173 ◽  
Author(s):  
Katie Goodwin ◽  
Michal Abrahamowicz ◽  
Gabriel Leonard ◽  
Michel Perron ◽  
Louis Richer ◽  
...  
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Visceral Adiposity ◽  
Retinol Binding Protein ◽  
Dietary Vitamin ◽  
Retinol Binding Protein 4

Retinol-Binding Protein in Idiopathic Intracranial Hypertension (IIH)

2001 ◽  
Vol 20 (4) ◽  
pp. 250-252 ◽  
Author(s):  
John B. Selhorst ◽  
Kongkiat Kulkantrakorn ◽  
James J. Corbett ◽  
Enrique C. Leira ◽  
Sophia M. Chung
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Binding Protein ◽  
Retinol Binding Protein

Retinol binding protein 4 and its membrane receptors: a metabolic perspective

2015 ◽  
Vol 22 (1) ◽  
Author(s):  
Ronja Fedders ◽  
Matthias Muenzner ◽  
Michael Schupp
Keyword(s):  
Metabolic Diseases ◽  
Binding Protein ◽  
Current Data ◽  
Membrane Receptors ◽  
Retinol Binding Protein ◽  
Metabolic Effects ◽  
Retinol Binding Protein 4 ◽  
Underlying Mechanisms

AbstractNearly a decade of intense research has passed since the first report linking circulating retinol binding protein 4 (RBP4) to the development of insulin resistance. By now, a variety of underlying mechanisms have been identified; some of them are adherent to the canonical role of this circulating protein, which is to transport and deliver retinol to target tissues, and others that seem rather independent of retinol transport. Despite all these efforts, a consensus in the basic principles of RBP4’s metabolic effects has not been reached and some controversy remains. Using this as an opportunity, we here review and discuss current data on RBP4’s action on insulin sensitivity and its dependency on retinol homeostasis. We pay special attention to the involvement of RBP4 membrane receptors that were identified during these years, such as ‘stimulated by retinoic acid 6’ (STRA6), and whose identification added another layer of complexity to RBP4’s diverse actions. A better understanding of RBP4’s functions might allow its therapeutic exploitations, urgently needed in our period that is defined by an epidemic increase in metabolic diseases such as obesity and type 2 diabetes.

scholarly journals Retinol Binding Protein 4 Levels relate to the presence and severity of coronary artery disease

2021 ◽  
Author(s):  
Gokay Nar ◽  
Sara Cetin Sanlialp ◽  
Rukiye Nar
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
The Relationship

Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD).  However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study. Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion. Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014).  RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.

Retinol-Binding Protein in Idiopathic Intracranial Hypertension (IIH)

2001 ◽  
Vol 20 (4) ◽  
pp. 250-252
Author(s):  
John B. Selhorst ◽  
Kongkiat Kulkantrakorn ◽  
James J. Corbett ◽  
Enrique C. Leira ◽  
Sophia M. Chung
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Binding Protein ◽  
Retinol Binding Protein

Cerebrospinal fluid markers of idiopathic intracranial hypertension: Is the renin-angiotensinogen system involved?

Cephalalgia ◽  
2010 ◽  
Vol 31 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Johannes Brettschneider ◽  
Nele Hartmann ◽  
Vera Lehmensiek ◽  
Helga Mogel ◽  
Albert C Ludolph ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Binding Protein ◽  
Regulatory Element ◽  
Renin Angiotensin System ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Candidate Protein ◽  
Alpha 1 Antitrypsin

Background: The causes underlying idiopathic intracranial hypertension (IIH) are poorly understood. Methods: To identify disease-related biomarkers that could offer a new insight into IIH pathology, we analyzed the cerebrospinal fluid (CSF) of 18 patients with IIH and 18 controls using two-dimensional fluorescence differential in-gel electrophoresis (2-D DIGE). Results: We found six proteins that were upregulated in IIH (sterol regulatory element-binding protein 1, zinc-alpha-2-glycoprotein, immunoglobulin heavy constant alpha 1 [IGHA1], alpha-1-antitrypsin [SERPINA1], serotransferrin, haptoglobin) and four proteins that were downregulated (hemopexin, angiotensinogen, vitamin-D-binding protein, transthyretin). The validity of our approach was confirmed for one candidate protein (angiotensinogen). To account for a dependency from blood-CSF barrier function, the ratio of angiotensinogen and albumin CSF-to-serum quotients (Qang/Qalb) was determined, which confirmed the downregulation of angiotensinogen in IIH ( p = .04). Conclusion: Previous studies showed the intrinsic renin-angiotensin system (RAS) to regulate choroid plexus blood flow and CSF production. Altered levels of angiotensinogen could indicate an imbalance of the RAS in IIH that may provide new targets for therapeutic intervention.

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