PSA and prostatic biopsies

1998 ◽  
Vol 65 (1) ◽  
pp. 94-96
Author(s):  
S. Bartolotta ◽  
G. Amuso ◽  
M. D'alessandro ◽  
A.M. Paradiso ◽  
F. Savoca ◽  
...  
Keyword(s):  
Clinical Practice ◽  
High Probability ◽  
Prostatic Carcinoma ◽  
Transrectal Ultrasound ◽  
Digital Rectal Examination ◽  
Prostatic Hyperplasia ◽  
Ultrasound Guided ◽  
Prostatic Biopsy ◽  
Prostate Size ◽  
Prostatic Adenomas

High PSA concentrations are often, but not always, a sign of prostatic carcinoma and it is therefore necessary to correlate the PSA values with the increase in prostate size. Increases in PSA up to 10 ng/ml in relation to large prostatic adenomas may be an expression of benign prostatic hyperplasia instead of prostatic carcinoma. In clinical practice it is important to correlate the PSA value with the digital rectal examination and the transrectal ultrasound: only when two of these three data are positive is there a high probability of prostatic carcinoma. The aim of this study was to compare PSA serum concentration values with the ultrasound-guided perineal prostatic biopsy in order to check the sensitivity and specificity of PSA, in particular when ambiguous values were obtained.

scholarly journals Effect of different manipulations on serum PSA in patients with benign prostatic hyperplasia.

2021 ◽  
Vol 28 (06) ◽  
pp. 866-871
Author(s):  
Muhammad Iqbal ◽  
M. Adil Khurshid ◽  
Sohail Hassan ◽  
Manzoor Ahmad Naeem ◽  
Shahid Niaz ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Digital Rectal Examination ◽  
Management Plan ◽  
Significant Rise ◽  
Prostatic Hyperplasia ◽  
Transurethral Resection Of Prostate ◽  
Ultrasound Guided ◽  
Prostatic Biopsy ◽  
Rectal Examination ◽  
Rectal Ultrasound

Objectives: To evaluate the effect of different urological manipulations on the serum PSA level in patients with benign prostatic hyperplasia. Study Design: Quasi-experimental study. Setting: Department of Urology, Nawaz Sharif Social Security Hospital, Lahore. Period: January 2018 to December 2018. Material & Methods: A series of 60 patients were included in the study who fulfill the inclusion criteria. All the patients were above 50 years of age and presented with symptoms of benign prostatic hyperplasia. These patients were divided into four groups equally. In group A digital rectal examination, in group B transurethral resection of prostate, in group C Foley’s catheterization and in group D Trans rectal ultrasound guided prostatic biopsy was done. Pre-manipulation and post-manipulation blood samples for serum PSA were taken after 30 minutes, 72 hours and one week. Results: Trans urethral resection of prostate, Foley's catheterization and trans rectal ultrasound guided prostatic biopsy caused a statistically significant rise in serum PSA level (p < 0.05) while digital rectal examination did not raise serum PSA level significantly. Conclusion: Different manipulations do cause alteration in the serum PSA level which may change the management plan.

scholarly journals Hemosepermia after transrectal ultrasound-guided prostatic biopsy: A prospective study

2013 ◽  
Vol 5 (1) ◽  
pp. 30 ◽  
Author(s):  
M Abdelkhalek ◽  
M Abdelshafy ◽  
H Elhelaly ◽  
M Kamal
Keyword(s):  
Prospective Study ◽  
Transrectal Ultrasound ◽  
Ultrasound Guided ◽  
Prostatic Biopsy ◽  
A Prospective Study

Malakoplakia prostate presenting as urinary retention: a report of two cases and review of the literature

2021 ◽  
Vol 14 (7) ◽  
pp. e243927
Author(s):  
Swaroop Subbaraya ◽  
Ajit Sawant ◽  
Prakash Pawar ◽  
Sunil Patil
Keyword(s):  
Urinary Retention ◽  
Acute Urinary Retention ◽  
Specific Antigen ◽  
Transrectal Ultrasound ◽  
Transurethral Resection Of Prostate ◽  
Review Of The Literature ◽  
Ultrasound Guided ◽  
Prostatic Biopsy ◽  
Chronic Inflammatory Condition

Malakoplakia is a rare chronic inflammatory condition, which primarily occurs in genitourinary tract, with prostatic malakoplakia being extremely rare. We present two cases of acute urinary retention, with clinically firm nodular prostate and a raised serum prostate-specific antigen. Transrectal ultrasound-guided prostatic biopsy showed features of malakoplakia. There was a significant reduction of size of prostate on transrectal ultrasonography after 4 weeks of antibiotics. However, one patient had failed trial without catheter and was subjected to transurethral resection of prostate. The biopsy of the prostatic chips also showed features of malakoplakia. Other patient improved symptomatically after antibiotics and was managed conservatively. Both the patients are on regular follow-up and are asymptomatic. Prostatic malakoplakia presenting as urinary retention is very uncommon with around 12 cases in the literature. Recognition of prostatic malakoplakia is important because clinically it can masquerade prostatic malignancy. Treatment with antibiotics is necessary before subjecting the patients for surgery in patients with obstructive symptoms.

scholarly journals The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

2020 ◽  
Vol 38 (11) ◽  
pp. 2923-2931
Author(s):  
Y. Wu ◽  
Y. Ding ◽  
Q. F. Cao ◽  
S. B. Qian ◽  
C. Wang ◽  
...  
Keyword(s):  
Growth Rate ◽  
Benign Prostatic Hyperplasia ◽  
Glucose Homeostasis ◽  
Transrectal Ultrasound ◽  
Transitional Zone ◽  
Prostatic Hyperplasia ◽  
Significant Difference ◽  
Prostate Size ◽  
Prostate Growth ◽  
The Relationship

Abstract Purpose Increasing evidence shows that many metabolic factors are involved in the progression of benign prostatic hyperplasia (BPH). We aimed to assess the relationship between the status of glucose homeostasis and prostate size in aging Chinese males undergoing transurethral resection of the prostate (TURP) for BPH. Methods A total of 1006 medical records of BPH patients undergoing TURP were reviewed. Prostate size was measured by transrectal ultrasound. Annual total prostate (TP) and transitional zone (TZ) growth rates were calculated. According to the American Diabetes Association criteria, the patients were categorized as normoglycemic, prediabetic, or diabetic. Levels of glucose homeostasis and other variables were considered independent variables in an effort to evaluate any potential correlations using non-adjusted and multivariate-adjusted regression models. Results A total of 659 individuals were included in the study. BPH patients < 70 years old and ≥ 70 years old in the normoglycemic group had a stable prostate growth rate. The change in prostate size in those younger than 70 years, however, was faster in the prediabetic and diabetic group. Further analysis revealed that abnormal glucose homeostasis was positively correlated with prostate size. In those younger than 70 years, compared with the normal glucose group, the adjusted odds ratio (OR) for TP and TZ enlargement in the prediabetic group was 2.27 (95%CI 1.29–4.00) and 3.19 (95%CI 1.78–5.72), respectively, and the adjusted ORs were 4.74 (95%CI 2.18–10.30) and 6.16 (95%CI 2.70–14.06), respectively, for men with diabetes. However there was no significant difference among men aged ≥ 70 years. Conclusions Among patients undergoing TURP, the prostate volume and growth rate were affected by different status of glucose homeostasis. Hyperglycemia may play an important role in prostate growth.

Granulomatous prostatitis: A clinico-pathological series of 27 cases

2020 ◽  
pp. 205141582097042
Author(s):  
Pooja Suteri ◽  
Arvind Ahuja ◽  
Achin K Sen ◽  
Hemant Goel ◽  
Minakshi Bhardwaj ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Histopathological Examination ◽  
Specific Antigen ◽  
Transrectal Ultrasound ◽  
Digital Rectal Examination ◽  
Prostatic Hyperplasia ◽  
Definitive Diagnosis ◽  
Patient Records ◽  
Age Range ◽  
Granulomatous Prostatitis

Objectives: This study aimed to assess the incidence and discern the histomorphological spectrum of granulomatous prostatitis. Methods: A retrospective analysis of histopathological records of 1773 prostatic specimens received in the pathology department was done over a period of seven years. All histologically proven cases of granulomatous prostatitis were retrieved, the relevant clinical data were collected from patient records and the lesions were categorized accordingly. Results: Out of 1773 cases, 27 cases of granulomatous prostatitis were identified. The age range of these patients was between 50 and 89 years. Among the patients, non-specific granulomatous prostatitis (NSGP) was the most common followed by tubercular prostatitis, post-surgical prostatitis and xanthogranulomatous prostatitis. Three cases of post-surgical prostatitis were associated with malignancy. Serum prostate-specific antigen (PSA) levels ranged between 0.8 and 20.94 ng/mL (median 10.78 ng/mL). The diagnosis was made by histopathological examination of transrectal ultrasound (TRUS)-guided core biopsies, Trucut biopsies, transuretheral resection of prostate chips, prostatectomy and cystoprostatectomy specimens. Conclusion: In the present study, the incidence of granulomatous prostatitis was 1.5%. The patients usually present as hard nodules on digital rectal examination along with raised serum PSA levels. Carcinoma or benign prostatic hyperplasia was kept as a clinical diagnosis in these cases. Since the diagnosis of granulomatous prostatitis is made on histopathological examination only, meticulous histomorphological assessment is therefore required to reach a definitive diagnosis of granulomatous prostatitis.

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