Alteration of the Redox State of Nadph and Glutathione in Perfused Rabbit Lung By Paraquat
1986 ◽
Vol 2
(4)
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pp. 417-428
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Keyword(s):
The glutathione and NADP + status of perfused rabbit lung was deter mined both before and after perfusion with 1 mM paraquat. The pul monary glutathione redox state was similar to that of liver, having a glutathione/glutathione disulfide ratio of about 240. This ratio was lower in lungs perfused with glucose-free medium, a condition in which NADPH probably becomes limiting. Perfusion with paraquat signifi cantly increased the pulmonary glutathione disulfide content, particu larly in the absence of glucose, resulting in a glutathionelglutathione disulfide ratio of <100. NADP+ levels in rabbit lung were increased approximately two-fold by perfusion with paraquat in medium con taining glucose and three-fold in the absence of glucose.
2010 ◽
Vol 323
(2)
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pp. 147-154
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Keyword(s):
2008 ◽
Vol 10
(4)
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pp. 821-828
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2009 ◽
Vol 103
(8)
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pp. 1110-1117
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Keyword(s):