A Modified Simple Scoring System Using the Red Blood Cell Distribution Width, Delta Neutrophil Index, and Mean Platelet Volume-to-Platelet Count to Predict 28-Day Mortality in Patients With Sepsis

2020 ◽  
pp. 088506662093324
Author(s):  
Jun hyoung Kim ◽  
Yongseop Lee ◽  
Yun Suk Cho ◽  
Yu Jin Sohn ◽  
Jong Hoon Hyun ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Scoring System ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
New Scoring ◽  
Red Blood Cell Distribution ◽  
Delta Neutrophil Index

Background: Recently, a new scoring system was developed that uses the red blood cell distribution width (RDW), delta neutrophil index (DNI), and platelet count (PC) to predict mortality in patients with sepsis. We investigated whether a modified simple scoring system based on the RDW, DNI, and mean platelet volume-to-PC (MPV/PC) ratio could predict the mortality of patients with sepsis, and compared it to the previous scoring system. Methods: We conducted a retrospective cohort study of 264 adults who had been treated for sepsis in an emergency department between January 2016 and February 2019. Each patient was rated on a scale of 0 to 3 according to the modified scoring system. Point values were assigned based on RDW > 14.5%, DNI > 5.0%, and MPV/PC ratio >10.1. Results: The 28-day mortality rate was 14.4%. Those who died had higher scores than those who survived (mean: 1.55 ± 0.92 vs 0.93 ± 0.78, P < .001). The area under the curve for the new scoring system was higher than that of the previous scoring system (0.685 vs 0.645). Conclusion: The modified scoring system was a good predictor of the 28-day mortality and was more useful than the previous scoring system for predicting mortality in patients with sepsis.

A Simple Scoring System Using the Red Blood Cell Distribution Width, Delta Neutrophil Index, and Platelet Count to Predict Mortality in Patients With Severe Sepsis and Septic Shock

2018 ◽  
Vol 34 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Yong Chan Kim ◽  
Je Eun Song ◽  
Eun Jin Kim ◽  
Heun Choi ◽  
Woo Yong Jeong ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Platelet Count ◽  
Scoring System ◽  
Cell Distribution ◽  
Distribution Width ◽  
Sepsis And Septic Shock ◽  
New Scoring ◽  
Red Blood Cell Distribution ◽  
Delta Neutrophil Index

Purpose: The purpose of our study was to investigate whether a simple scoring system based on the red blood cell distribution width (RDW), delta neutrophil index (DNI), and platelet count was associated with the prognosis of patients with sepsis, and whether this scoring system was more useful than each individual parameter. Materials and Methods: We conducted a retrospective cohort study involving adult patients who received intensive therapy due to severe sepsis and septic shock from January 2010 to December 2015 at a tertiary teaching hospital in South Korea. Results: A total of 730 patients were included in this study. Each patient was rated on a scale of 0 to 3 according to the new scoring system using the platelet count, RDW, and DNI. Point values were assigned based on the following definitions: RDW > 14.5%, DNI > 5.0%, and platelet count < 150 000/mm3. The 28-day mortality rate was 12.6% (92/730). The nonsurvivors had higher scores than the survivors (2.05 ± 0.80 vs 1.06 ± 0.87, P < .001). In the multivariate Cox proportional hazard analysis, the scoring system was an independent predictor of the 28-day mortality. The scoring system was well calibrated ( P = .81 for the goodness-of-fit test) and discriminated (area under the receiver operating characteristic curve = 0.785). Conclusion: Our new scoring system using the RDW, DNI, and platelet count was useful for predicting the mortality in patients with severe sepsis and septic shock.

scholarly journals Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1175-1181
Author(s):  
Na Cai ◽  
Zhi Qiang Chen ◽  
Min Tao ◽  
Wen Ting Fan ◽  
Wei Liao
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Late Onset ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
Premature Neonates ◽  
Survivor Group ◽  
Late Onset Sepsis ◽  
Red Blood Cell Distribution

Abstract Objective To evaluate the prognostic value of the mean platelet volume (MPV) and red blood cell distribution width (RDW) in sepsis among premature neonates. Methods This was a retrospective cohort study conducted in the neonatal intensive care unit between May 2015 and May 2020. Premature neonates with late-onset sepsis were enrolled. The demographic data, blood cell count analysis, C-reactive protein, and blood culture were compared between survivors and non-survivors. Results A total of 73 premature neonates with sepsis in the survivor group and 10 cases in the non-survivor group. Significant differences were observed between the survivor and non-survivor groups with regard to birth weight, MPV, and RDW (P < 0.05). The results of binomial stepwise logistic regression suggested that MPV (OR = 3.226, P = 0.017 < 0.05) and RDW (OR = 2.058, P = 0.019 < 0.05) were independent predictor for prognosis in preterm with sepsis. A receiver operating characteristic analysis showed that the areas under the curves were 0.738 for MPV alone, 0.768 for RDW alone, and 0.854 for MPV combined with RDW. Conclusion MPV and RDW were independent predictors of prognosis and the combination of the two helps in predicting the prognosis of preterm with late-onset sepsis in the early stage.

scholarly journals Analysis of mean platelet volume and red blood cell distribution width in recurrent epistaxis

2018 ◽  
Vol 18 (2) ◽  
pp. 67-70 ◽  
Author(s):  
Ali Ekber Karabulut ◽  
Yunsur Çevik ◽  
Emine Emektar ◽  
Şeref Kerem Çorbacioğlu ◽  
Seda Dağar ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Mean Platelet Volume ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
Recurrent Epistaxis ◽  
Red Blood Cell Distribution
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