A Simple Scoring System Using the Red Blood Cell Distribution Width, Delta Neutrophil Index, and Platelet Count to Predict Mortality in Patients With Severe Sepsis and Septic Shock

2018 ◽  
Vol 34 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Yong Chan Kim ◽  
Je Eun Song ◽  
Eun Jin Kim ◽  
Heun Choi ◽  
Woo Yong Jeong ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Platelet Count ◽  
Scoring System ◽  
Cell Distribution ◽  
Distribution Width ◽  
Sepsis And Septic Shock ◽  
New Scoring ◽  
Red Blood Cell Distribution ◽  
Delta Neutrophil Index

Purpose: The purpose of our study was to investigate whether a simple scoring system based on the red blood cell distribution width (RDW), delta neutrophil index (DNI), and platelet count was associated with the prognosis of patients with sepsis, and whether this scoring system was more useful than each individual parameter. Materials and Methods: We conducted a retrospective cohort study involving adult patients who received intensive therapy due to severe sepsis and septic shock from January 2010 to December 2015 at a tertiary teaching hospital in South Korea. Results: A total of 730 patients were included in this study. Each patient was rated on a scale of 0 to 3 according to the new scoring system using the platelet count, RDW, and DNI. Point values were assigned based on the following definitions: RDW > 14.5%, DNI > 5.0%, and platelet count < 150 000/mm3. The 28-day mortality rate was 12.6% (92/730). The nonsurvivors had higher scores than the survivors (2.05 ± 0.80 vs 1.06 ± 0.87, P < .001). In the multivariate Cox proportional hazard analysis, the scoring system was an independent predictor of the 28-day mortality. The scoring system was well calibrated ( P = .81 for the goodness-of-fit test) and discriminated (area under the receiver operating characteristic curve = 0.785). Conclusion: Our new scoring system using the RDW, DNI, and platelet count was useful for predicting the mortality in patients with severe sepsis and septic shock.

A Modified Simple Scoring System Using the Red Blood Cell Distribution Width, Delta Neutrophil Index, and Mean Platelet Volume-to-Platelet Count to Predict 28-Day Mortality in Patients With Sepsis

2020 ◽  
pp. 088506662093324
Author(s):  
Jun hyoung Kim ◽  
Yongseop Lee ◽  
Yun Suk Cho ◽  
Yu Jin Sohn ◽  
Jong Hoon Hyun ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Scoring System ◽  
Cell Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
New Scoring ◽  
Red Blood Cell Distribution ◽  
Delta Neutrophil Index

Background: Recently, a new scoring system was developed that uses the red blood cell distribution width (RDW), delta neutrophil index (DNI), and platelet count (PC) to predict mortality in patients with sepsis. We investigated whether a modified simple scoring system based on the RDW, DNI, and mean platelet volume-to-PC (MPV/PC) ratio could predict the mortality of patients with sepsis, and compared it to the previous scoring system. Methods: We conducted a retrospective cohort study of 264 adults who had been treated for sepsis in an emergency department between January 2016 and February 2019. Each patient was rated on a scale of 0 to 3 according to the modified scoring system. Point values were assigned based on RDW > 14.5%, DNI > 5.0%, and MPV/PC ratio >10.1. Results: The 28-day mortality rate was 14.4%. Those who died had higher scores than those who survived (mean: 1.55 ± 0.92 vs 0.93 ± 0.78, P < .001). The area under the curve for the new scoring system was higher than that of the previous scoring system (0.685 vs 0.645). Conclusion: The modified scoring system was a good predictor of the 28-day mortality and was more useful than the previous scoring system for predicting mortality in patients with sepsis.

scholarly journals An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock

Critical Care ◽  
2013 ◽  
Vol 17 (6) ◽  
pp. R282 ◽  
Author(s):  
Chan Ho Kim ◽  
Jung Tak Park ◽  
Eun Jin Kim ◽  
Jae Hyun Han ◽  
Ji Suk Han ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock

2013 ◽  
Vol 31 (6) ◽  
pp. 989-990 ◽  
Author(s):  
Sevket Balta ◽  
Sait Demirkol ◽  
Mustafa Hatipoglu, ◽  
Sukru Ardic ◽  
Zekeriya Arslan ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Sepsis And Septic Shock

Red cell distribution width is a prognostic factor in severe sepsis and septic shock

2013 ◽  
Vol 31 (3) ◽  
pp. 545-548 ◽  
Author(s):  
You Hwan Jo ◽  
Kyuseok Kim ◽  
Jae Hyuk Lee ◽  
Changwoo Kang ◽  
Taegyun Kim ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Prognostic Factor ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Sepsis And Septic Shock

scholarly journals The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

2019 ◽  
Vol 2 (1) ◽  
pp. 58-66
Author(s):  
Emanuel Moisă ◽  
Silvius Negoiţă ◽  
Dan Corneci
Keyword(s):  
Septic Shock ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hematological Parameter ◽  
Component Part ◽  
Cell Distribution ◽  
Prognosis Factor ◽  
Distribution Width ◽  
Severity Scores ◽  
Red Blood Cell Distribution

AbstractRed blood cell distribution width (RDW) is a hematological parameter usually measured with every complete blood count. Its place in daily practice is mainly in the differential diagnosis of anemia, but nowadays, researchers are focused on different approaches for the erythrocyte’s changes in function and morphology.Sepsis and its most advanced form, septic shock, induces profound disturbances into organ system’s function and morphology. The red blood cells physiology and structure are directly and indirectly altered by these im balances produced in sepsis. RDW was studied in many diseases, like acute heart failure, acute stroke, inflammatory bowel diseases, chronic lung diseases and cancer, but also in sepsis. Its changes are seen to be mainly associated with prognosis. Higher values of RDW are correlated with mortality and severity of illnes in septic and all-cause critically ill patients. RDW was studied also as an independent variable in different predictive scores and some studies suggest it should be introduced in the scores use on a daily basis in critical care settings and emergency departments.In this review we will focus on how RDW was associated with mortality and severity of illness in the recent literature, as an independent prognosis factor and as a component part in different predictive and severity scores.

Evaluation of red cell distribution width (RDW) as a septic marker in comparison with clinical scores and C-reactive protein

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ali Ahmed Naga ◽  
Mohammed Ismaeil Abdel Fattah ◽  
Walid Hamed Nofal ◽  
Mohammed Abd-elsalam AlMenshawe
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Distribution Width ◽  
Clinical Scores ◽  
Group I ◽  
Significant Difference ◽  
Sepsis And Septic Shock

Abstract Background Challenges of diagnosing and treating sepsis only seem more difficult as incidence increases, patients become older and sicker, and pathogenic organisms evolve. New understanding of inflammatory mediators and pathways, immunity, and genetic variability in this disease state suggests that the current definitions of SIRS, sepsis, severe sepsis, and septic shock are oversimplified. Objective The aim of our study is to evaluate the level of RDW, CRP and clinical scores "SOFA and APACHI" as markers in patients with sepsis and their levels on the outcome and resolution of sepsis in ICU. Methodology We conducted a prospective observational controlled study on 90 adult persons of both sex, 45 of them are adult patients and served as the study group (Group I), and the other 45 are healthy adult volunteers and served as the control group (Group II). The study group represented patients admitted to the ICU of Intensive Care Unit at Damanhour Medical National Institute who fulfilled the diagnostic criteria for sepsis, severe sepsis and septic shock on arrival to ICU according to the SCCM/ ESICM/ ACCP/ ATS/SIS International Sepsis Definitions Conference. Results. In the present study we found that CRP measured on admission was not a predictor of mortality, while that measured at day 5 and day 10 predicted mortality, where there was no statistically significant difference in CRP levels between survivors and non-survivors at the day of admission while there were statistically significant differences between survivors and non survivors according to CRP levels at day 5 (p = 0.001*) and at day 10 (p = 0.001*). It was found also that there were statistically significant differences between survivors and non-survivors according to RDW at day 1(p = 0.011*) and at day 5(p = 0.009*), at day 10 was found there was no statistically significant difference between survivors and non-survivors (p = 0.338). Conclusion RDW is a new promising cheap and readily available biomarker that can be able to diagnose patients with sepsis with accuracy comparable to CRP. Also, RDW at admission is able to predict mortality.

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