Artificial diffusion in the simulation of micromixers: A review

Author(s):  
Morteza Bayareh

False (artificial) diffusion provides an erroneous estimation of molecular diffusion during the simulation of liquid micromixing. The present review introduces discretization methods, numerical grid types, and numerical errors to address the effect of false diffusion on the prediction of mixing efficiency of microfluidic devices. False diffusivity is characterized by the grid Peclet number, grid type, and discretization scheme. This review demonstrates that most investigators have selected a grid resolution just for the grid independence test. It is revealed that the convergence criterion should not be quantitative values of mixing efficiency even when high-order schemes are employed to discretize the computational grid. Based on the previous publications in this field, a straightforward procedure is recommended to manage false diffusion in the numerical simulation of micromixers.

Micromachines ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1055
Author(s):  
Alireza Farahinia ◽  
Jafar Jamaati ◽  
Hamid Niazmand ◽  
Wenjun Zhang

One approach to achieve a homogeneous mixture in microfluidic systems in the quickest time and shortest possible length is to employ electroosmotic flow characteristics with heterogeneous surface properties. Mixing using electroosmotic flow inside microchannels with homogeneous walls is done primarily under the influence of molecular diffusion, which is not strong enough to mix the fluids thoroughly. However, surface chemistry technology can help create desired patterns on microchannel walls to generate significant rotational currents and improve mixing efficiency remarkably. This study analyzes the function of a heterogeneous zeta-potential patch located on a microchannel wall in creating mixing inside a microchannel affected by electroosmotic flow and determines the optimal length to achieve the desired mixing rate. The approximate Helmholtz–Smoluchowski model is suggested to reduce computational costs and simplify the solving process. The results show that the heterogeneity length and location of the zeta-potential patch affect the final mixing proficiency. It was also observed that the slip coefficient on the wall has a more significant effect than the Reynolds number change on improving the mixing efficiency of electroosmotic micromixers, benefiting the heterogeneous distribution of zeta-potential. In addition, using a channel with a heterogeneous zeta-potential patch covered by a slip surface did not lead to an adequate mixing in low Reynolds numbers. Therefore, a homogeneous channel without any heterogeneity would be a priority in such a range of Reynolds numbers. However, increasing the Reynolds number and the presence of a slip coefficient on the heterogeneous channel wall enhances the mixing efficiency relative to the homogeneous one. It should be noted, though, that increasing the slip coefficient will make the mixing efficiency decrease sharply in any situation, especially in high Reynolds numbers.


1982 ◽  
Vol 52 (3) ◽  
pp. 624-633 ◽  
Author(s):  
C. Bowes ◽  
G. Cumming ◽  
K. Horsfield ◽  
J. Loughhead ◽  
S. Preston

An asymmetrical model of the human pulmonary acinus is described, in which elements of volume are represented by nodes joined by conductors permitting convective flow and molecular diffusion. The method of analysis permits simultaneous convection, diffusion, and dimensional change in any direction and requires only simple boundary conditions. Inspiration of O2 into a resident gas of 79% N2 followed by expiration was simulated at two flows. On expiration the slope of the alveolar plateau was 1.7%, and the alveolar N2 mixing efficiency was 97.0%. A symmetrical but otherwise similar model gave a slope of zero and a mixing efficiency of 99.9%. The patterns of gas concentration within the asymmetrical acinus during the respiratory cycle confirm and extend previous observations on the interactions between simultaneous convection and diffusion in asymmetrical structures (16, 21, 22). Even though these in combination within alveolar duct asymmetry can account for the slope of the alveolar plateau, they are insufficient to account for the failure of complete gas mixing found in normal subjects.


Geophysics ◽  
2013 ◽  
Vol 78 (6) ◽  
pp. F17-F27 ◽  
Author(s):  
Erica Galetti ◽  
David Halliday ◽  
Andrew Curtis

Improvements in industrial seismic, seismological, acoustic, or interferometric theory and applications often result in quite subtle changes in sound quality, seismic images, or information which are nevertheless crucial for improved interpretation or experience. When evaluating new theories and algorithms using synthetic data, an important aspect of related research is therefore that numerical errors due to wavefield modeling are reduced to a minimum. We present a new MATLAB code based on the Foldy method that models theoretically exact, direct, and scattered parts of a wavefield. Its main advantage lies in the fact that while all multiple scattering interactions are taken into account, unlike finite-difference or finite-element methods, numerical dispersion errors are avoided. The method is therefore ideal for testing new theory in industrial seismics, seismology, acoustics, and in wavefield interferometry in particular because the latter is particularly sensitive to the dynamics of scattering interactions. We present the theory behind the Foldy acoustic modeling method and provide examples of its implementation. We also benchmark the code against a good finite-difference code. Because our Foldy code was written and optimized to test new theory in seismic interferometry, examples of its application to seismic interferometry are also presented, showing its validity and importance when exact modeling results are needed.


Ocean Science ◽  
2009 ◽  
Vol 5 (3) ◽  
pp. 271-283 ◽  
Author(s):  
R. Tailleux

Abstract. There exist two central measures of turbulent mixing in turbulent stratified fluids that are both caused by molecular diffusion: 1) the dissipation rate D(APE) of available potential energy APE; 2) the turbulent rate of change Wr, turbulent of background gravitational potential energy GPEr. So far, these two quantities have often been regarded as the same energy conversion, namely the irreversible conversion of APE into GPEr, owing to the well known exact equality D(APE)=Wr, turbulent for a Boussinesq fluid with a linear equation of state. Recently, however, Tailleux (2009) pointed out that the above equality no longer holds for a thermally-stratified compressible, with the ratio ξ=Wr, turbulent/D(APE) being generally lower than unity and sometimes even negative for water or seawater, and argued that D(APE) and Wr, turbulent actually represent two distinct types of energy conversion, respectively the dissipation of APE into one particular subcomponent of internal energy called the "dead" internal energy IE0, and the conversion between GPEr and a different subcomponent of internal energy called "exergy" IEexergy. In this paper, the behaviour of the ratio ξ is examined for different stratifications having all the same buoyancy frequency N vertical profile, but different vertical profiles of the parameter Υ=α P/(ρCp), where α is the thermal expansion coefficient, P the hydrostatic pressure, ρ the density, and Cp the specific heat capacity at constant pressure, the equation of state being that for seawater for different particular constant values of salinity. It is found that ξ and Wr, turbulent depend critically on the sign and magnitude of dΥ/dz, in contrast with D(APE), which appears largely unaffected by the latter. These results have important consequences for how the mixing efficiency should be defined and measured in practice, which are discussed.


2009 ◽  
Vol 6 (1) ◽  
pp. 371-387
Author(s):  
R. Tailleux

Abstract. There exist two central measures of turbulent diffusive mixing in turbulent stratified fluids, which are both caused by molecular diffusion: 1) the dissipation rate D(APE) of available potential energy APE; 2) the rate of change Wr,mixing of background gravitational potential energy GPEr. So far, these two quantities have often been regarded as representing the same kind of energy conversion, i.e., the irreversible conversion of APE into GPEr, owing to the well known result that D(APE)≈Wr,mixing in a Boussinesq fluid with a linear equation of state. Here, this idea is challenged by showing that while D(APE) remains largely unaffected by a nonlinear equation of state, Wr,mixing is in contrast strongly affected by the latter. This result is rationalized by using the recent results of Tailleux (2008), which argues that D(APE) represents the dissipation of APE into one particular subcomponent of internal energy called the "dead" internal energy IE0, whereas Wr,mixing represents the conversion between a different subcomponent of internal energy – called the "exergy" IEexergy – and GPEr. It follows that the concept of mixing efficiency, which represents the fraction of the stirring mechanical energy ultimately dissipated by molecular diffusion is related to D(APE), not Wr,mixing, which ensures that it should be largely unaffected by the nonlinear character of the equation of state, and therefore correctly described in the context of a Boussinesq fluid with a linear equation of state. The variations of GPEr, on the other hand, are sensitive to the linear or nonlinear character of the equation of state.


2016 ◽  
Vol 65 (1) ◽  
pp. 13-40
Author(s):  
Roman Kadaj

Abstract The paper presents empirical methodology of reducing various kinds of observations in geodetic network. A special case of reducing the observation concerns cartographic mapping. For numerical illustration and comparison of methods an application of the conformal Gauss-Krüger mapping was used. Empirical methods are an alternative to the classic differential and multi-stages methods. Numerical benefits concern in particular very long geodesics, created for example by GNSS vectors. In conventional methods the numerical errors of reduction values are significantly dependent on the length of the geodesic. The proposed empirical methods do not have this unfavorable characteristics. Reduction value is determined as a difference (or especially scaled difference) of the corresponding measures of geometric elements (distances, angles), wherein these measures are approximated independently in two spaces based on the known and corresponding approximate coordinates of the network points. Since in the iterative process of the network adjustment, coordinates of the points are systematically improved, approximated reductions also converge to certain optimal values.


1984 ◽  
Vol 56 (2) ◽  
pp. 418-425 ◽  
Author(s):  
M. Paiva ◽  
L. A. Engel

Alveolar gas concentrations were simulated in an asymmetrically branching model of a human lung acinus based on morphometric measurements. The structure was expansile so that convective flow into and out of every part was proportional to its volume. Despite the homogeneous volume change solution of a differential equation for simultaneous convection and molecular diffusion following a 1-liter breath of O2 at 0.5 l/s predicted substantial inhomogeneity of O2 concentrations. This was reflected in a twofold range of inspired gas per unit volume computed from O2 concentrations averaged throughout expiration. Even a 10-s breath hold at end inspiration did not result in uniform concentrations. Larger breaths, corresponding to a ventilation of 60 l/min, increased the degree of inhomogeneity 50%. Diffusive pendelluft at intra-acinar branch points during expiration produced a sloping alveolar plateau of 0.53% N2/l, i.e., much smaller than that measured from the whole lung in vivo. Similarly, an estimate of single-breath mixing efficiency also indicated a much smaller degree of inhomogeneity than inferred from measurements of expired gases at the mouth. The model analysis suggests that if anatomical data used are representative of a normal lung, then the intra-acinar gas inhomogeneity, although substantial, constitutes a small fraction of the overall impairment in gas mixing.


Micromachines ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 372
Author(s):  
Mahmut Burak Okuducu ◽  
Mustafa M. Aral

Passive micromixers are miniaturized instruments that are used to mix fluids in microfluidic systems. In microchannels, combination of laminar flows and small diffusion constants of mixing liquids produce a difficult mixing environment. In particular, in very low Reynolds number flows, e.g., Re < 10, diffusive mixing cannot be promoted unless a large interfacial area is formed between the fluids to be mixed. Therefore, the mixing distance increases substantially due to a slow diffusion process that governs fluid mixing. In this article, a novel 3-D passive micromixer design is developed to improve fluid mixing over a short distance. Computational Fluid Dynamics (CFD) simulations are used to investigate the performance of the micromixer numerically. The circular-shaped fluid overlapping (CSFO) micromixer design proposed is examined in several fluid flow, diffusivity, and injection conditions. The outcomes show that the CSFO geometry develops a large interfacial area between the fluid bodies. Thus, fluid mixing is accelerated in vertical and/or horizontal directions depending on the injection type applied. For the smallest molecular diffusion constant tested, the CSFO micromixer design provides more than 90% mixing efficiency in a distance between 260 and 470 µm. The maximum pressure drop in the micromixer is found to be less than 1.4 kPa in the highest flow conditioned examined.


2017 ◽  
Vol 823 ◽  
pp. 198-229 ◽  
Author(s):  
Qi Zhou ◽  
J. R. Taylor ◽  
C. P. Caulfield ◽  
P. F. Linden

The mixing properties of statically stable density interfaces subject to imposed vertical shear are studied using direct numerical simulations of stratified plane Couette flow. The simulations are designed to investigate possible self-maintaining mechanisms of sharp density interfaces motivated by Phillips’ argument (Deep-Sea Res., vol. 19, 1972, pp. 79–81) by which layers and interfaces can spontaneously form due to vertical variations of diapycnal flux. At the start of each simulation, a sharp density interface with the same initial thickness is introduced at the midplane between two flat, horizontal walls counter-moving at velocities$\pm U_{w}$. Particular attention is paid to the effects of varying Prandtl number$\mathit{Pr}\equiv \unicode[STIX]{x1D708}/\unicode[STIX]{x1D705}$, where$\unicode[STIX]{x1D708}$and$\unicode[STIX]{x1D705}$are the molecular kinematic viscosity and diffusivity respectively, over two orders of magnitude from 0.7, 7 and 70. Varying$\mathit{Pr}$enables the system to access a considerable range of characteristic turbulent Péclet numbers$\mathit{Pe}_{\ast }\equiv {\mathcal{U}}_{\ast }{\mathcal{L}}_{\ast }/\unicode[STIX]{x1D705}$, where${\mathcal{U}}_{\ast }$and${\mathcal{L}}_{\ast }$are characteristic velocity and length scales, respectively, of the motion which acts to ‘scour’ the density interface. The dynamics of the interface varies with the stability of the interface which is characterised by a bulk Richardson number$\mathit{Ri}\,\equiv \,b_{0}h/U_{w}^{2}$, where$b_{0}$is half the initial buoyancy difference across the interface and$h$is the half-height of the channel. Shear-induced turbulence occurs at small$\mathit{Ri}$, whereas internal waves propagating on the interface dominate at large$\mathit{Ri}$. For a highly stable (i.e. large$\mathit{Ri}$) interface at sufficiently large$\mathit{Pe}_{\ast }$, the complex interfacial dynamics allows the interface to remain sharp. This ‘self-sharpening’ is due to the combined effects of the ‘scouring’ induced by the turbulence external to the interface and comparatively weak molecular diffusion across the core region of the interface. The effective diapycnal diffusivity and irreversible buoyancy flux are quantified in the tracer-based reference coordinate proposed by Winters & D’Asaro (J. Fluid Mech., vol. 317, 1996, pp. 179–193) and Nakamura (J. Atmos. Sci., vol. 53, 1996, pp. 1524–1537), which enables a detailed investigation of the self-sharpening process by analysing the local budget of buoyancy gradient in the reference coordinate. We further discuss the dependence of the effective diffusivity and overall mixing efficiency on the characteristic parameters of the flow, such as the buoyancy Reynolds number and the local gradient Richardson number, and highlight the possible role of the molecular properties of fluids on diapycnal mixing.


Author(s):  
Aric M. Gillispie ◽  
Evan C. Lemley

The potential applications of micromixers continues to expand in the bio-sciences area. In particular, passive micromixers that may be used as part of point-of-care (POC) diagnostic testing devices are becoming commonplace and have application in developed, developing, and relatively undeveloped locales. Characterizing and improving mixing efficiency in these devices is an ongoing research effort. Micromixers are used in some lab-on-chip (LOC) devices where it is often necessary to combine two or more fluids into a mixed solution for testing or delivery. The simplest micromixer incorporates a tee junction to combine two fluid species in anti-parallel branches, with the mixed fluid leaving in a branch perpendicular to the incoming branches. Micromixers rely on two modes of mixing: chaotic advection and molecular diffusion. In micro-mixers flow is typically laminar, making chaotic advection occur only via induced secondary flows. Hence, micromixers, unless carefully designed, rely almost exclusively on molecular diffusion of fluid species. A well designed micromixer should exhibit significant chaotic advection; which is also a sign of large strain rates and large entropy generation rates. This paper describes the development of an analytical relationship for the entropy generation rate and the mixing efficiency as function of the outgoing branch Reynolds number. Though there has been extensive research on tee junctions, entropy generation, and the mixing efficiencies of a wide variety of micromixers, a functional relationship for the mixing efficiency and the entropy generation rate has not been established. We hypothesize a positive correlation between the mixing index and the entropy generation rate. The worked described here establishes a method and provides the results for such a relationship. A basic tee junction with square cross sections has been analyzed using computational fluid dynamics to determine the entropy generation rate and outgoing mixing efficiencies for Reynolds numbers ranging from 25–75. The mixing efficiency is determined at a location in the outgoing branch where the effects of molecular diffusive mixing is minimized and chaotic advective mixing is the focus. The entropy generation rate has been determined for the indicated range of Reynolds number and decomposed into its viscous and diffusive entropy terms. The functional relationships that have been developed are applicable for micromixer design and serve as a reference for more complex passive micromixer designs.


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