Cerebrospinal Fluid Proteins in Neurosyphilis and HIV Infection

1994 ◽  
Vol 5 (5) ◽  
pp. 310-317 ◽  
Author(s):  
G Keir
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Treponema Pallidum ◽  
Paper Briefly ◽  
Cerebrospinal Fluid Proteins ◽  
Immunodeficiency Virus ◽  
The Central Nervous System

This paper briefly reviews the factors which influence the concentrations of proteins, particularly immunoglobulins, within the CSF and how antibodies which are locally synthesized within the central nervous system can be detected by the laboratory. The use of nitrocellulose immunoblotting for the identification of antibodies which are specific to Treponema pallidum and Human Immunodeficiency Virus Type-1 are discussed.

scholarly journals Human immunodeficiency virus type 1 infection of the brain.

1993 ◽  
Vol 6 (4) ◽  
pp. 339-366 ◽  
Author(s):  
W J Atwood ◽  
J R Berger ◽  
R Kaderman ◽  
C S Tornatore ◽  
E O Major
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
Nervous System ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Early Years ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Hiv 1

Direct infection of the central nervous system by human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, was not appreciated in the early years of the AIDS epidemic. Neurological complications associated with AIDS were largely attributed to opportunistic infections that arose as a result of the immunocompromised state of the patient and to depression. In 1985, several groups succeeded in isolating HIV-1 directly from brain tissue. Also that year, the viral genome was completely sequenced, and HIV-1 was found to belong to a neurotropic subfamily of retrovirus known as the Lentivirinae. These findings clearly indicated that direct HIV-1 infection of the central nervous system played a role in the development of AIDS-related neurological disease. This review summarizes the clinical manifestations of HIV-1 infection of the central nervous system and the related neuropathology, the tropism of HIV-1 for specific cell types both within and outside of the nervous system, the possible mechanisms by which HIV-1 damages the nervous system, and the current strategies for diagnosis and treatment of HIV-1-associated neuropathology.

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