Contac 400: A Possible Cause of Aspiration Under Anaesthesia

D.J. Wilkinson

doi:10.1177/096032718700600615

Contac 400: A Possible Cause of Aspiration Under Anaesthesia

Human Toxicology ◽

10.1177/096032718700600615 ◽

1987 ◽

Vol 6 (6) ◽

pp. 529-531

Author(s):

D.J. Wilkinson

Keyword(s):

Over The Counter ◽

Counter Medication ◽

Life Threatening ◽

Anaesthetic Assessment ◽

Possible Cause

Patients often take proprietary medicines which they do not report to their anaesthetist. One such case is reported in which a self administered high dosage of such a medication can be linked with a potentially life threatening anaesthetic complication. Pre-anaesthetic assessment should include specific questioning on over-the-counter medication.

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A case of nimesulide induced toxic epidermal necrolysis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20201764 ◽

2020 ◽

Vol 9 (5) ◽

pp. 810

Author(s):

Suja Xaviar ◽

Mirunalini Ravichandran

Keyword(s):

Mortality Rate ◽

Toxic Epidermal Necrolysis ◽

Skin Disease ◽

The Body ◽

Drug Induced ◽

Over The Counter ◽

Life Threatening ◽

Cox 2 ◽

Adequate Management ◽

Possible Cause

Toxic epidermal necrolysis (TEN) is a rare life-threatening drug-induced mucocutaneous skin disease with a mortality rate of approximately 30%. Nimesulide is a preferential cyclo-oxygenase (COX-2) inhibitor which is frequently used for its antipyretic, anti-inflammatory and analgesic activity. Here, we report a case of nimesulide induced toxic epidermal necrolysis in a 57 years old male patient. This patient was admitted in the hospital with symptoms of epidermal sloughing and fluid filled blisters all over the body following over the counter intake of nimesulide for fever. The drug was promptly stopped, and patient was managed with steroids, antibiotics and other adequate supportive measures. The patient showed significant recovery following stoppage of drug and adequate management. This case highlights the importance of nimesulide and other NSAIDs as possible cause of TEN.

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Over-the-counter medication and acute life-threatening myocardial damage

International Journal of Cardiology ◽

10.1016/j.ijcard.2004.08.049 ◽

2005 ◽

Vol 102 (3) ◽

pp. 545-547 ◽

Cited By ~ 2

Author(s):

Masatsugu Nozoe ◽

Akira Namera ◽

Kazuaki Kohriyama ◽

Masao Takemoto

Keyword(s):

Myocardial Damage ◽

Over The Counter ◽

Counter Medication ◽

Life Threatening

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Use of Medication at the Roskilde (Denmark) Music Festival 2015 – A Prospective Observational Study of 15,133 Treated Attendees

Prehospital and Disaster Medicine ◽

10.1017/s1049023x19004606 ◽

2019 ◽

Vol 34 (04) ◽

pp. 407-414 ◽

Cited By ~ 1

Author(s):

Søren Stagelund ◽

Kenneth Geving Andersen ◽

Jesper Søe ◽

Michelle Roslind ◽

Kim Wildgaard

Keyword(s):

Prospective Observational Study ◽

Health Care Organization ◽

Care Organization ◽

Over The Counter ◽

Music Festivals ◽

Music Festival ◽

Large Numbers ◽

Counter Medication ◽

Medical Health Care ◽

Life Threatening

AbstractBackground:Outdoor music festivals (OMFs) attract large numbers of guests and benefit from the help of large numbers of volunteers. Studies have previously described the injury patterns at OMFs, but no studies have described the use of medication and sales from on-site pharmacies at a large OMF.Method:The usage of medication and prescriptions in the Medical Health Care Organization (MHCO), including sales from the on-site pharmacy, at the Roskilde (Denmark) Festival 2015 were prospectively recorded.Results:In excess of 130,000 attendees (guests and volunteers) participated in the Roskilde Festival 2015. The number of attendees contacting the MHCO was 15,133, of which 3,723 (25%) had a consultation with a doctor. Of all attendees evaluated by a doctor, 669 attendees received some form of medication in relation to the consultation. The MHCO administered and/or handed out a total of 6,494 units of prescription and over-the-counter medication, of which analgesics represented nearly 51%. Asthma was the condition with the highest proportion of attendees requiring pharmaceutical treatment, as 28 out of 48 (58%) received medication during the consultation. Sixty-five attendees received both medicine and a prescription. The MHCO handed out 562 prescriptions. In total, 609 prescriptions were redeemed at the on-site pharmacy. Antibiotics represented more than 78% of all redeemed prescriptions at the on-site pharmacy.Conclusion:The most utilized medications were analgesics and antibiotics. The data indicate a need for on-site prophylaxis using tetanus toxoid in combination with diphtheria toxoid vaccine and an on-site pharmacy. The content of the formulary at a mass-gathering event should be based on: evacuation time by ambulance/helicopter to hospitals with the level of competence needed; types of conditions to be treated on-site; level of competencies of festival medical staff; expected incidence and type of illness and injuries; and treatment of acute, life-threatening illnesses and or injuries.

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Cardiac Arrest Following the Administration of Intravenous Diphenhydramine for Sedation to an Infant With Congenital Heart Disease

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-26.3.311 ◽

2021 ◽

Vol 26 (3) ◽

pp. 311-314

Author(s):

Courtney L. Andersen ◽

Joseph D. Tobias

Keyword(s):

Cardiac Arrest ◽

Trisomy 21 ◽

First Generation ◽

Intravenous Route ◽

Allergic Reactions ◽

Over The Counter ◽

Respiratory Effects ◽

Counter Medication ◽

Life Threatening ◽

Pediatric Icu

Diphenhydramine (Benadryl) is a first-generation antihistamine that is used primarily to treat allergic reactions including anaphylaxis, urticaria, and allergic rhinitis. Despite its availability as an over-the-counter medication, toxicity may occur with its use especially when administered in large doses or via the intravenous route. We present a 3-month-old infant with Trisomy 21 who suffered a cardiac arrest immediately following administration of a single 1.25 mg/kg dose of intravenous diphenhydramine, prescribed for sedation in the Pediatric ICU setting. The potential cardiovascular and respiratory effects of diphenhydramine are presented, previous reports of life-threatening adverse effects reviewed, and options to limit these effects discussed.

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