scholarly journals Diet and lupus: what do the patients think?

Lupus ◽  
2019 ◽  
Vol 28 (6) ◽  
pp. 755-763 ◽  
Author(s):  
G A Robinson ◽  
T Mcdonnell ◽  
C Wincup ◽  
L Martin-Gutierrez ◽  
J Wilton ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Social Media ◽  
Lupus Erythematosus ◽  
Online Survey ◽  
Disease Risk ◽  
Therapeutic Option ◽  
Cardiovascular Disease Risk ◽  
Systemic Lupus ◽  
Effective Manner

Objectives Cardiovascular disease is the leading cause of mortality in patients with systemic lupus erythematosus. Therefore, using diet to control blood lipid levels and modify cardiovascular disease risk could be a promising therapeutic strategy to control disease symptoms. The primary objective of this study was to learn about systemic lupus erythematosus patient experiences with diet, including their opinion on considering diet as a therapeutic option. The secondary objective was to obtain this information in a cost- and time-effective manner. Methods A lay summary and a 15-question diet-based online survey were publicly available for 3 weeks. Social media was used to promote the survey through relevant charities, hospitals and research groups. Results A total of 300 responses were received, 284 from patients with systemic lupus erythematosus. Patients reported that there was a lack of clinical counselling regarding diet, with only 24% stating their doctor had spoken to them about diet. Despite this, 100% of patients stated they would change their diet if they knew it would help their symptoms and 83% would take part in a future diet-based clinical trial. Text analysis of patient research suggestions identified a particular interest in using diet to treat fatigue and manage disease flares. Conclusions This project successfully gathered patient information regarding diet and systemic lupus erythematosus over a short timeframe using an anonymous social media platform. The survey provided evidence that patients support further research and potential diet intervention studies investigating the effect of diet on the symptoms of systemic lupus erythematosus.

Dietary Inflammatory Index Score and Cardiovascular Disease Risk Markers in Women with Systemic Lupus Erythematosus

2020 ◽  
Vol 120 (2) ◽  
pp. 280-287 ◽  
Author(s):  
Gabriela Pocovi-Gerardino ◽  
María Correa-Rodríguez ◽  
Jose-Luis Callejas-Rubio ◽  
Raquel Ríos-Fernández ◽  
María Martín-Amada ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Lupus Erythematosus ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Index Score ◽  
Risk Markers ◽  
Dietary Inflammatory Index ◽  
Systemic Lupus ◽  
Inflammatory Index

scholarly journals Cardiovascular disease risk awareness in systemic lupus erythematosus patients

2008 ◽  
Vol 58 (5) ◽  
pp. 1458-1464 ◽  
Author(s):  
Lisabeth V. Scalzi ◽  
Stanley P. Ballou ◽  
Jean Y. Park ◽  
Susan Redline ◽  
H. Lester Kirchner
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Lupus Erythematosus ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Risk Awareness ◽  
Systemic Lupus

scholarly journals Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Leda Coelewij ◽  
Kirsty E. Waddington ◽  
George A. Robinson ◽  
Elvira Chocano ◽  
Thomas McDonnell ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Logistic Regression ◽  
Lupus Erythematosus ◽  
Serum Lipid ◽  
Free Cholesterol ◽  
Disease Risk ◽  
Subclinical Atherosclerosis ◽  
Cardiovascular Disease Risk ◽  
Systemic Lupus

Objective: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular disease. Standard serum lipid measurements in clinical practice do not predict cardiovascular disease risk in patients with SLE. More detailed analysis of lipoprotein taxonomy could identify better predictors of cardiovascular disease risk in SLE. Approach and Results: Eighty women with SLE and no history of cardiovascular disease underwent carotid and femoral ultrasound scans; 30 had atherosclerosis plaques (patients with SLE with subclinical plaque) and 50 had no plaques (patients with SLE with no subclinical plaque). Serum samples obtained at the time of the scan were analyzed using a lipoprotein-focused metabolomics platform assessing 228 metabolites by nuclear magnetic resonance spectroscopy. Data were analyzed using logistic regression and 5 binary classification models with 10-fold cross validation. Patients with SLE had global changes in complex lipoprotein profiles compared with healthy controls despite having clinical serum lipid levels within normal ranges. In the SLE cohort, univariate logistic regression identified 4 metabolites associated with subclinical plaque; 3 subclasses of VLDL (very low-density lipoprotein; free cholesterol in medium and large VLDL particles and phospholipids in chylomicrons and extremely large VLDL particles) and leucine. Together with age, these metabolites were also within the top features identified by the lasso logistic regression (with and without interactions) and random forest machine learning models. Logistic regression with interactions differentiated between patients with SLE with subclinical plaque and patients with SLE with no subclinical plaque groups with the greatest accuracy (0.800). Notably, free cholesterol in large VLDL particles and age differentiated between patients with SLE with subclinical plaque and patients with SLE with no subclinical plaque in all models. Conclusions: Serum metabolites are promising biomarkers to uncover and predict multimetabolic phenotypes of subclinical atherosclerosis in SLE.

Adipokines and Systemic Lupus Erythematosus: Relationship with Metabolic Syndrome and Cardiovascular Disease Risk Factors

2009 ◽  
Vol 36 (2) ◽  
pp. 295-297 ◽  
Author(s):  
MARTA VADACCA ◽  
DOMENICO MARGIOTTA ◽  
AMELIA RIGON ◽  
FABIO CACCIAPAGLIA ◽  
GIUSY COPPOLINO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Lupus Erythematosus ◽  
Disease Risk ◽  
Activity Index ◽  
Cardiovascular Disease Risk ◽  
Systemic Lupus ◽  
The Metabolic Syndrome

Objective.To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors.Methods.We enrolled 50 SLE patients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits.Results.MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLE patients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLE patients and controls.Conclusion.Leptin was increased in SLE patients and could play a role in SLE-related cardiovascular diseases.

scholarly journals QRISK3 improves detection of cardiovascular disease risk in patients with systemic lupus erythematosus

2018 ◽  
Vol 5 (1) ◽  
pp. e000272 ◽  
Author(s):  
Nicola Edwards ◽  
Alexander W W Langford-Smith ◽  
Benjamin J Parker ◽  
Ian N Bruce ◽  
John A Reynolds ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Lupus Erythematosus ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Systemic Lupus
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