Cardiac Rehabilitation in Patients with Peripheral Artery Disease—A Literature Review in COVID-19 Era

Cardiac rehabilitation (CR) is an integral part of the management of various cardiovascular disease such as coronary artery disease (CAD), peripheral artery disease (PAD), or chronic heart failure (CHF), with proven morbidity and mortality benefits. This article aims to review and summarize the scientific literature related to cardiac rehabilitation programs for patients with PAD and how they were adapted during the COVID-19 pandemic. The implementation of CR programs has been problematic since the COVID-19 pandemic due to social distancing and work-related restrictions. One of the main challenges for physicians and health systems alike has been the management of PAD patients. COVID-19 predisposes to coagulation disorders that can lead to severe thrombotic events. Home-based walking exercises are more accessible and easier to accept than supervised exercise programs. Cycling or other forms of exercise are more entertaining or challenging alternatives to exercise therapy. Besides treadmill exercises, upper- and lower-extremity ergometry also has great functional benefits, especially regarding walking endurance. Supervised exercise therapy has a positive impact on both functional capacity and also on the quality of life of such patients. The most effective manner to acquire this seems to be by combining revascularization therapy and supervised exercise. Rehabilitation programs proved to be a mandatory part of the integrative approach in these cases, increasing quality of life, and decreasing stress levels, depression, and anxiety.

Recycling of Post-Consumer Packaging Materials into New Food Packaging Applications—Critical Review of the European Approach and Future Perspectives

The European strategy for plastics, as part of the EU’s circular economy action plan, should support the reduction in plastic waste. One key element in this action plan is the improvement of the economics and quality of recycled plastics. In addition, an important goal is that by 2030, all plastics packaging placed on the EU market must either be reusable or can be recycled in a cost-effective manner. This means that, at the end, a closed-loop recycling of food packaging materials should be established. However, the use of recyclates must not result in less severe preventive consumer protection of food packaging materials. This may lead to a conservative evaluation of authorities on post-consumer recyclates in food packaging applications. On the other hand, over-conservatism might over-protect the consumer and generate insurmountable barriers to the application of post-consumer recyclates for food packaging and, hence, counteract the targets of circular economy. The objective of this review is to provide an insight into the evaluation of post-consumer recyclates applied in direct contact to food. Safety assessment criteria as developed by the European Food Safety Authority EFSA will be presented, explained, and critically discussed.

Micronutrients in Food Production: What Can We Learn from Natural Ecosystems?

Soil micronutrients limit crop productivity in many regions worldwide, and micronutrient deficiencies affect over two billion people globally. Microbial biofertilizers could combat these issues by inoculating arable soils with microorganisms that mobilize micronutrients, increasing their availability to crop plants in an environmentally sustainable and cost-effective manner. However, the widespread application of biofertilizers is limited by complex micronutrient–microbe–plant interactions, which reduce their effectiveness under field conditions. Here, we review the current state of seven micronutrients in food production. We examine the mechanisms underpinning microbial micronutrient mobilization in natural ecosystems and synthesize the state-of-knowledge to improve our overall understanding of biofertilizers in food crop production. We demonstrate that, although soil micronutrient concentrations are strongly influenced by soil conditions, land management practices can also substantially affect micronutrient availability and uptake by plants. The effectiveness of biofertilizers varies, but several lines of evidence indicate substantial benefits in co-applying biofertilizers with conventional inorganic or organic fertilizers. Studies of micronutrient cycling in natural ecosystems provide examples of microbial taxa capable of mobilizing multiple micronutrients whilst withstanding harsh environmental conditions. Research into the mechanisms of microbial nutrient mobilization in natural ecosystems could, therefore, yield effective biofertilizers to improve crop nutrition under global changes.

Cybersecurity, Data Privacy and Blockchain: A Review

In this paper, we identify and review key challenges to bridge the knowledge-gap between SME’s, companies, organisations, businesses, government institutions and the general public in adopting, promoting and utilising Blockchain technology. The challenges indicated are Cybersecurity and Data privacy in this instance. Additional challenges are set out supported by literature, in researching data security management systems and legal frameworks to ascertaining the types and varieties of valid encryption, data acquisition, policy and outcomes under ISO 27001 and the General Data Protection Regulations. Blockchain, a revolutionary method of storage and immutability, provides a robust storage strategy, and when coupled with a Smart Contract, gives users the ability to form partnerships, share information and consent via a legally-based system of carrying out business transactions in a secure digital domain. Globally, ethical and legal challenges significantly differ; consent and trust in the public and private sectors in deploying such defensive data management strategies, is directly related to the accountability and transparency systems in place to deliver certainty and justice. Therefore, investment and research in these areas is crucial to establishing a dialogue between nations to include health, finance and market strategies that should encompass all levels of society. A framework is proposed with elements to include Big Data, Machine Learning and Visualisation methods and techniques. Through the literature we identify a system necessary in carrying out experiments to detect, capture, process and store data. This includes isolating packet data to inform levels of Cybersecurity and privacy-related activities, and ensuring transparency demonstrated in a secure, smart and effective manner.

A Flexibility Market Platform for Electricity System Operators Using Blockchain Technology

The paper’s main objective is to demonstrate the trading and flexibility of services amongst TSOs, DSOs, and Prosumers in a transparent, secure, and cost-effective manner using Blockchain-based TSO-DSO flexibility marketplace (EFLEX). The aim is to look for ways to help DSOs/TSOs be more flexible and more directly engaged in managing energy flows on the network. EFLEX will streamline the needs of both TSO and DSO on the same platform. Based on the paper’s proposed services, the pilot service demonstration will be carried out in Bulgaria and Romania, and the main focus will be on congestion management, TSO-DSO Coordination, and Marketplace. The proposed objective is achieved by using Blockchain-based smart contracts and distributed ledger technology.

Augmenting recombinant antibody production in HEK293E cells: Optimising transfection and culture parameters

Background Optimising recombinant antibody production is important for cost-effective therapeutics and diagnostics. With impact on commercialisation, higher productivity beyond laboratory scales is highly sought, where efficient production can also accelerate antibody characterisations and investigations. Methods Investigating HEK293E cells for mammalian antibody production, various transfection and culture parameters were systematically analysed for antibody light chain production before evaluating them for whole antibody production. Transfection parameters investigated include seeding cell density, the concentration of the transfection reagent and DNA, complexation time, temperature, and volume, as well as culture parameters such as medium replacement, serum deprivation, use of cell maintenance antibiotic, incubation temperature, medium volume, post-transfection harvest day and common nutrient supplements. Results Using 2 mL adherent HEK293E cell culture transfections with 25 kDa linear Polyethylenimine in the most optimised parameters, we demonstrated a ~ 2-fold production increase for light chain alone and for whole antibody production reaching 536 and 49 μg respectively in a cost-effective manner. With the addition of peptone, κ light chain increased by ~ 4-fold to 1032 μg while whole antibody increased to a lesser extent by ~ 2.5-fold to 51 μg, with benefits potentially for antibodies limited by their light chains in production. Conclusions Our optimised findings show promise for a more efficient and convenient antibody production method through transfection and culture optimisations that can be incorporated to scale up processes and with potential transferability to other mammalian-based recombinant protein production using HEK293E cells. Statement of Significance Recombinant antibody production is crucial for antibody research and development. Systematically investigating transfection and culture parameters such as PEI/DNA concentrations, complexation time, volume, and temperature, supplements, etc., we demonstrated a ~ 4-fold light chain alone production increase to 1032 μg and a 2.5-fold whole antibody production increase to 51 μg from 2 mL transfections.

The Rating of Confusion in Supply Chain Dynamics in Food Business and Selecting the Most Ideal Capacity Strategy During COVID-19

Supply chain dynamics are seen as important components that directly affect supply chain performance, business processes, management functions, and efficiency for businesses. Every company in the supply chain needs other businesses to achieve the desired level of supply accurately, with the least cost and in an effective manner. Therefore, supply chain dynamics are seen as important components in terms of increasing competitiveness, increasing business performance, avoiding problems in workflows, and ensuring customer satisfaction, and also play critical roles in the provision of necessary information, materials, and services and improvement of process management. Also, capacity and capacity development strategies have vital importance, and firms need to apply right strategies in order to achieve success.In this study, it is aimed to rank the confusion in the supply chain dynamics and select the most ideal capacity strategy for food establishments with 10 or more employees operating in Giresun province during the COVID-19 process via SWARA and WASPAS methods.

Strategic Human Resource Management

Human resource management has become an integral part of management with the basic aim of maintaining better human relations at work place through the application and evaluation of organizational policies and programs so as to utilize human resources in an optimized and effective manner. In this context, this chapter focuses keenly on the various domains centering around human resource management. Initially a detailed theoretical background regarding this construct has been presented followed by highlighting the components and objectives of strategizing human resource management. Lastly, the models and perspectives pertaining to strategic human resource management have also been discussed considering their application and relevance in modern-day organizations.

The BIMSTEC Free Trade Area

The Bay of Bengal Initiative for Multi-Sectoral Technical and Economic Cooperation (BIMSTEC) is a regional cooperation between Bangladesh, India, Sri Lanka, Bhutan, Nepal, Myanmar, and Thailand since the liberalization of these economies. Member countries need to be more proactive for integrated regional cooperative hubs to enhance trade and investment opportunities in health and other sectors of the economy to cope with the pandemic and its impact. The aim of this chapter is to show how BIMSTEC, a regional cooperative body, can be a driver for socio-economic development, inter-regional trade, and investment opportunities for BIMSTEC countries and cope with COVID-19 and its impact. The BIMSTEC area is home to approximately 1.6 billion citizens accounting to 22% of the worlds inhabitants with a joint gross domestic product (GDP) of 2.7 trillion. Unemployment situation of ‘new poor' can be tackled through close cooperation among the BIMSTEC nations in an effective manner to achieve ‘pareto optimality' through trade and investment among member countries.

Blockchain

A blockchain is a specific database stored in an electronic form. The databases stored in a block are put in a chain. When new data is added, it will be put in a new block. The blockchain may be created for storing different kind of information in which the most popular use of blockchain is ledger for transactions. Anything of value can be put in a blockchain, and this will reduce risk factors and cost. The blockchain is a chain of blocks used to store public databases. The blockchain can be a powerful tool in business applications for sharing and updating data. The blockchain may be used for the business process for handling transaction-related problems in an effective manner. The blockchain is also helpful in developing an ecosystem between various stakeholders. The policies, benefits, and cost are serious risk factors.