On the role of finite mixture models in survival analysis

1994 ◽  
Vol 3 (3) ◽  
pp. 211-226 ◽  
Author(s):  
GJ McLachlan ◽  
DC McGiffin
Author(s):  
Geoffrey J. McLachlan ◽  
Sharon X. Lee ◽  
Suren I. Rathnayake

The important role of finite mixture models in the statistical analysis of data is underscored by the ever-increasing rate at which articles on mixture applications appear in the statistical and general scientific literature. The aim of this article is to provide an up-to-date account of the theory and methodological developments underlying the applications of finite mixture models. Because of their flexibility, mixture models are being increasingly exploited as a convenient, semiparametric way in which to model unknown distributional shapes. This is in addition to their obvious applications where there is group-structure in the data or where the aim is to explore the data for such structure, as in a cluster analysis. It has now been three decades since the publication of the monograph by McLachlan & Basford (1988) with an emphasis on the potential usefulness of mixture models for inference and clustering. Since then, mixture models have attracted the interest of many researchers and have found many new and interesting fields of application. Thus, the literature on mixture models has expanded enormously, and as a consequence, the bibliography here can only provide selected coverage.


PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260748
Author(s):  
Ibrahim Al-Sumaih ◽  
Michael Donnelly ◽  
Ciaran O’Neill

Background Recorded serum 25(OH)D in survey data varies with observed and unobserved respondent characteristics. The aim of this study was to expose latent population sub-groups and examine variation across groups regarding relationships between serum 25(OH)D and observable characteristics. Methods This study explored the role of unobserved heterogeneity on associations between surveyed 25(OH)D and various factors using a sample (n = 2,641) extracted from the Saudi Health Interview Survey (2013). Linear regression and finite mixture models (FMM) were estimated and compared. The number of latent classes in the FMM was chosen based on BIC score. Result Three latent classes were identified. Class I (39.82%), class II (41.03%), and class III (19.15%) with mean 25(OH)D levels of 22.79, 34.88, and 57.45 ng/ml respectively. Distinct patterns of associations with nutrition, behaviour and socio-demographic variables were recorded across classes that were not revealed in pooled linear regression. Conclusion FMM has the potential to provide additional insights on the relationship between 25(OH)D levels and observable characteristics. It should be more widely considered as a method of investigation in this area.


Risks ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 115
Author(s):  
Despoina Makariou ◽  
Pauline Barrieu ◽  
George Tzougas

The key purpose of this paper is to present an alternative viewpoint for combining expert opinions based on finite mixture models. Moreover, we consider that the components of the mixture are not necessarily assumed to be from the same parametric family. This approach can enable the agent to make informed decisions about the uncertain quantity of interest in a flexible manner that accounts for multiple sources of heterogeneity involved in the opinions expressed by the experts in terms of the parametric family, the parameters of each component density, and also the mixing weights. Finally, the proposed models are employed for numerically computing quantile-based risk measures in a collective decision-making context.


2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Javier Juan-Albarracín ◽  
Elies Fuster-Garcia ◽  
Alfons Juan ◽  
Juan M. García-Gómez

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