scholarly journals Canine Liver Iron, Copper, and Zinc Concentrations and Association with Histologic Lesions

2002 ◽  
Vol 14 (5) ◽  
pp. 396-402 ◽  
Author(s):  
Patricia C. Schultheiss ◽  
Cathy L. Bedwell ◽  
Dwayne W. Hamar ◽  
Martin J. Fettman
Keyword(s):  
Iron Concentration ◽  
Dry Weight ◽  
Liver Iron ◽  
Inflammatory Lesions ◽  
Liver Copper ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
High Liver ◽  
Iron Concentrations

Concentrations of iron, copper, and zinc were measured in livers of 95 dogs that were suspected of having liver disease. Iron concentrations ranged from 177 to 7,680 ppm (dry weight basis); 54 dogs had iron concentrations greater than the normal concentration of 1,200 ppm. Iron stores were present in Kupffer cells and macrophages but not hepatocytes. The dogs did not have lesions of hemochromatosis. Dogs with high liver iron tended to have high liver copper and inflammatory lesions. High liver copper concentrations usually were associated with hepatocellular necrosis and fibrosis. High liver zinc was found in only 5 animals and was accompanied by histologic inflammatory lesions in one. In humans, increased iron concentration in the liver exacerbates liver damage caused by a variety of insults, and the same may be true for dogs.

Evaluation of iron, copper and zinc concentrations in commercial foods formulated for healthy cats

2021 ◽  
pp. 1098612X2110262
Author(s):  
Stacie Summers ◽  
Jonathan Stockman ◽  
Jennifer A Larsen
Keyword(s):  
Food Products ◽  
Metabolizable Energy ◽  
Life Stages ◽  
Trace Mineral ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
Dry Food ◽  
Raw Foods ◽  
Mineral Concentrations

Objectives The aim of this study was to analyze iron, copper and zinc concentrations in commercial foods and compare among food formats (dry, canned, raw), foods marketed by age category (adult 1+ years and senior 7+ years) and foods intended for adult maintenance vs all life stages. Methods In total, 112 commercial non-therapeutic food products marketed for healthy adult and senior cats were purchased in the USA. Foods were analyzed for their proximate composition. Trace mineral concentrations were measured using inductively coupled argon plasma–optical emission spectroscopy and described on a calculated metabolizable energy basis using standard modified Atwater values. Results Measured iron (median 58.4 mg/1000 kcal [range 15.7–379.0]), copper (median 5.6 mg/1000 kcal [range 0.8–13.3]) and zinc (median 47.6 mg/1000 kcal [range 7.6–128.1]) concentrations were highly variable among cat foods. When all food products – regardless of their nutritional adequacy substantiation method – were compared with the Association of American Feed Control Officials regulatory minimums, 13/112 food products had a mineral deficiency, of which a majority (n = 11/13) were raw food products. Raw foods had significantly lower trace mineral concentrations compared with dry food products and, except for copper, canned food products. Cat foods marketed for senior cats had higher iron ( P = 0.019) and zinc ( P <0.0001) concentrations than foods marketed for adult cats. Foods intended for adult maintenance had higher iron ( P = 0.003) and zinc concentrations than foods intended for all life stages ( P <0.0001). Conclusions and relevance Iron, copper and zinc concentrations in commercial non-therapeutic foods for adult and senior cats are highly variable. A minority of foods – mainly raw food products – were deficient in these minerals. It is unknown if some foods with high trace mineral concentrations could have adverse effects as studies are needed to establish safe upper limits for dietary intake of trace minerals in healthy cats.

scholarly journals Concentration of Trace Metals (Lead, Iron, Copper and Zinc) In Crops Harvested in Some Oil Prospecting Locations in River State, Nigeria

2005 ◽  
Vol 5 (9) ◽  
pp. 01-21
Author(s):  
Alexander Hart ◽  
◽  
Oboh CA ◽  
Barimalaa IS ◽  
TG Sokari
Keyword(s):  
Trace Metals ◽  
State University ◽  
Industrial Base ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Port Harcourt ◽  
Zinc Concentrations ◽  
Hibiscus Esculentus ◽  
High Level ◽  
Rivers State

Concentrations of the trace metals lead, iron, copper and zinc were estimated in crops harvested in some oil prospecting locations in Rivers State, Nigeria. The locations were; Agbada-Aluu (AA), Ebocha (EB), Idu Ekpeye (IE), Obagi (OB) and Trans Amadi Layout (TA), with the Teaching and Research Farm of Rivers State University of Science and Technology, Port Harcourt as control. Crops investigated were cassava (Manihot esculenta), cocoyam (Colocasia esculenta), okra (Hibiscus esculentus), pumpkin leaves (Telfairia occidentalis) and waterleaf (Talinum traingulare). Results of the mean lead concentrations were from 1.1µg/g in cocoyam to 9.1 µg/g in okro, showing higher trends in the industrialized areas. While cocoyam had the lowest lead concentration, the concentration rest of the crops did not differ significantly from one another. Crops from locations TA, OB, IE and EB had significantly higher concentrations of lead, although IE, AA and TF were not significantly different from one another. Mean concentrations of iron were between 40 µg/g in cassava from TF, and 651 µg/g in pumpkin leaves from TA - the industrial base of Rivers State - reflecting a high level of pollution from the various industries in that location. Differences in concentration of iron in crops showed pumpkin leaves to have the highest level of iron, followed by the other green vegetables – waterleaf and okra - although no significant differences occurred between okra, cocoyam and cassava. Copper concentrations were between 4.4 µg/g in cocoyam from locations TF and 23 µg/g in pumpkin leaves from TA. Pumpkin leaves had the highest concentrations of copper, followed by okra, then waterleaf, with cocoyam and cassava having the least significant levels. Zinc concentrations in crops were between 29 µg/g in cocoyam from TF to 240 µg/g in pumpkin leaves from EB. Pumpkin leaves and okra contained the highest levels of the metal, followed by waterleaf, then cassava and finally cocoyam. In terms of location, TA, OB and EB had the highest concentrations in crops, the least occurring in TF and AA. These results reflect higher concentrations of metals in crops from the industrialized locations, with the green vegetables, particularly pumpkin leaves, having the highest uptake, while cocoyam invariably had the least. These findings give cause for concern, particularly as heavy metals are bio-accumulative in the system and portend a serious health risk to man and animals.

Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up

Blood ◽  
2011 ◽  
Vol 118 (4) ◽  
pp. 884-893 ◽  
Author(s):  
M. Domenica Cappellini ◽  
Mohamed Bejaoui ◽  
Leyla Agaoglu ◽  
Duran Canatan ◽  
Marcello Capra ◽  
...  
Keyword(s):  
Adverse Events ◽  
Iron Concentration ◽  
Iron Chelation ◽  
Dry Weight ◽  
Thalassemia Major ◽  
Efficacy And Safety ◽  
Liver Iron ◽  
Median Serum

Abstract Patients with β-thalassemia require lifelong iron chelation therapy from early childhood to prevent complications associated with transfusional iron overload. To evaluate long-term efficacy and safety of once-daily oral iron chelation with deferasirox, patients aged ≥ 2 years who completed a 1-year, phase 3, randomized trial entered a 4-year extension study, either continuing on deferasirox (deferasirox cohort) or switching from deferoxamine to deferasirox (crossover cohort). Of 555 patients who received ≥ 1 deferasirox dose, 66.8% completed the study; 43 patients (7.7%) discontinued because of adverse events. In patients with ≥ 4 years' deferasirox exposure who had liver biopsy, mean liver iron concentration significantly decreased by 7.8 ± 11.2 mg Fe/g dry weight (dw; n = 103; P < .001) and 3.1 ± 7.9 mg Fe/g dw (n = 68; P < .001) in the deferasirox and crossover cohorts, respectively. Median serum ferritin significantly decreased by 706 ng/mL (n = 196; P < .001) and 371 ng/mL (n = 147; P < .001), respectively, after ≥ 4 years' exposure. Investigator-assessed, drug-related adverse events, including increased blood creatinine (11.2%), abdominal pain (9.0%), and nausea (7.4%), were generally mild to moderate, transient, and reduced in frequency over time. No adverse effect was observed on pediatric growth or adolescent sexual development. This first prospective study of long-term deferasirox use in pediatric and adult patients with β-thalassemia suggests treatment for ≤ 5 years is generally well tolerated and effectively reduces iron burden. This trial was registered at www.clinicaltrials.gov as #NCT00171210.

Mineral absorption of diets containing natural carob fiber compared to cellulose, pectin and various combinations of these fibers Absorción de minerales de dietas que contienen fibra natural de algarrobas comparada con celulosa, pectina y varias combinaciones de estas fibras

2000 ◽  
Vol 6 (6) ◽  
pp. 463-471 ◽  
Author(s):  
M.P. Vaquero ◽  
L. Perez-Olleros ◽  
M. Garcia-Cuevas ◽  
M. Veldhuizen ◽  
B. Ruiz-Roso ◽  
...  
Keyword(s):  
Iron Absorption ◽  
Calcium Absorption ◽  
Iron Concentration ◽  
Liver Iron Concentration ◽  
Liver Iron ◽  
Final Body Weight ◽  
Mineral Absorption ◽  
Apparent Absorption ◽  
Zinc Concentrations ◽  
Calcium Magnesium

The influence of the consumption of natural carob fiber (NCF), an insoluble hypocholesterolemic fiber, as the unique dietary fiber or combined with cellulose (CEL) or pectin (PEC), on mineral bioavailability was studied. Six groups of rats were fed for 10 days diets containing 10% CEL, NCF, PEC or CEL+NCF, CEL+PEC and NCF+PEC mixtures at 50%. Food intake was lower with PEC than NCF and CEL+NCF, but final body weight was unaffected. Fecal weight showed significant differ ences in the following order: CEL, NCF, CEL+NCF > CEL+PEC, NCF+PEC > PEC. Percentage of calcium absorption was higher with CEL+PEC and NCF+PEC compared with the rest of fibers. Mag nesium absorption was also significantly enhanced in these two groups compared to NCF (p < 0.0004). Iron absorption did not show variations. Zinc apparent absorption was reduced by PEC, but the NCF+PEC mixture counterbalanced this effect. Liver iron was significantly lower with NCF+PEC than CEL, and liver iron concentration was significantly lower with NCF+PEC compared to CEL+PEC. Liver zinc was significantly higher with CEL+NCF than PEC while liver zinc concentrations were slightly higher with the former (p = 0.05 compared to NCF). The results indicate that NCF, compared to CEL and PEC, did not decrease the efficiency of calcium, magnesium and iron absorption in rats, while compared to PEC it increased zinc apparent absorption. Moreover, by combining NCF with PEC calcium and magnesium, absorptions enhanced in comparison with NCF alone, which was prob ably a result of the combination of soluble and insoluble fibers.

Iron Stores in Patients with Myelodysplasia and Aplastic Anemia.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3726-3726
Author(s):  
Peter Nielsen ◽  
Tim H. Bruemmendorf ◽  
Regine Grosse ◽  
Rainer Engelhardt ◽  
Nicolaus Kroeger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Iron Overload ◽  
Aplastic Anemia ◽  
Myelodysplastic Syndromes ◽  
Iron Concentration ◽  
Dry Weight ◽  
Iron Toxicity ◽  
Intervention Threshold ◽  
Liver Iron Concentration ◽  
Liver Iron

Abstract Patients with myelodysplastic syndromes (MDS), osteomyelofibrosis (OMF), or severe aplastic anemia (SAA) suffer from ineffective erythropoiesis due to pancytopenia, which is treated with red blood cell transfusion leading to iron overload. Especially in low-risk patients with mean survival times of > 5 years, potentially toxic levels of liver iron concentration (LIC) can be reached. We hypothesize that the higher morbidity seen in transfused patients may be influenced by iron toxicity. Following a meeting in Nagasaki 2005, a consensus statement on iron overload in myelodysplastic syndromes has been published, however, there is still no common agreement about the initiation of chelation treatment in MDS patients. In the present study, a total of 67 transfused patients with MDS (n = 20, age: 17 – 75 y), OMF (n = 4, age: 48 – 68 y), SAA (n = 43, age: 5 – 64 y) were measured by SQUID biomagnetic liver susceptometry (BLS) and their liver and spleen volumes were scanned by ultrasound at the Hamburg biosusceptometer. Less than 50 % were treated with DFO. LIC (μg/g-liver wet weight, conversion factor of about 6 for μg/g-dry weight) and volume data were retrospectively analyzed in comparison to ferritin values. Additionally, 15 patients (age: 8 – 55 y) between 1 and 78 months after hematopoietic cell transplantation (HCT) were measured and analyzed. LIC values ranged from 149 to 8404 with a median value of 2705 μg/g-liver, while serum ferritin (SF) concentrations were between 500 and 10396 μg/l with a median ratio of SF/LIC = 0.9 [(μg/l)/(μg/g-liver)] (range: 0.4 to 5.2). The Spearman rank correlation between SF and LIC was found to be highly significant (RS = 0.80, p < 0.0001), however, prediction by the linear regression LIC = (0.83± 0.08)·SF was poor (R2 = 0.5) as found also in other iron overload diseases. Although iron toxicity is a long-term risk factor, progression of hepatic fibrosis has been observed for LIC > 16 mg/g dry weight or 2667 μg/g-liver (Angelucci et al. Blood2002; 100:17–21) within 60 months and significant cardiac iron levels have been observed for LIC > 350 μmol/g or 3258 μg/g-liver (Jensen et al. Blood2003; 101:4632-9). The Angelucci threshold of hepatic fibrosis progression was exceeded by 51 % of our patients, while 39 % were exceeding the Jensen threshold of potential risk of cardiac iron toxicity. The total body iron burden is even higher as more than 50 % of the patients had hepatomegaly (median liver enlargement factor 1.2 of normal). A liver iron concentration of about 3000 μg/g-liver or 18 mg/g-dry weight has to be seen as latest intervention threshold for chelation treatment as MDS patients are affected by more than one risk factor. A more secure intervention threshold would be a LIC of 1000 μg/g-liver or 4 – 6 mg/g-dry weight, corresponding with a ferritin level of 900 μg/l for transfused MDS patients. Such a LIC value is not exceeded by most subjects with heterozygous HFE-associated hemochromatosis and is well tolerated without treatment during life-time. Non-invasive liver iron quantification offers a more reliable information on the individual range of iron loading in MDS which is also important for a more rational indication for a chelation treatment in a given patient.

scholarly journals Deferasirox Decreases Liver Iron Concentration in Iron-Overloaded Patients with Myelodysplastic Syndromes, Aplastic Anemia and Other Rare Anemias

2015 ◽  
Vol 134 (4) ◽  
pp. 233-242 ◽  
Author(s):  
Yutaka Kohgo ◽  
Akio Urabe ◽  
Yurdanur Kilinç ◽  
Leyla Agaoglu ◽  
Krzysztof Warzocha ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Myelodysplastic Syndromes ◽  
Iron Concentration ◽  
Dry Weight ◽  
Japanese Patients ◽  
Efficacy And Safety ◽  
Liver Iron Concentration ◽  
Open Label ◽  
Liver Iron ◽  
Therapeutic Goals

Iron overload in transfusion-dependent patients with rare anemias can be managed with chelation therapy. This study evaluated deferasirox efficacy and safety in patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemias. A 1-year, open-label, multicenter, single-arm, phase II trial was performed with deferasirox (10-40 mg/kg/day, based on transfusion frequency and therapeutic goals), including an optional 1-year extension. The primary end point was a change in liver iron concentration (LIC) after 1 year. Secondary end points included changes in efficacy and safety parameters (including ophthalmologic assessments) overall as well as in a Japanese subpopulation. Overall, 102 patients (42 with MDS, 29 with AA and 31 with other rare anemias) were enrolled; 57 continued into the extension. Mean absolute change in LIC was -10.9 mg Fe/g dry weight (d.w.) after 1 year (baseline: 24.5 mg Fe/g d.w.) and -13.5 mg Fe/g d.w. after 2 years. The most common drug-related adverse event was increased serum creatinine (23.5%), predominantly in MDS patients. Four patients had suspected drug-related ophthalmologic abnormalities. Outcomes in Japanese patients were generally consistent with the overall population. Results confirm deferasirox efficacy in patients with rare anemias, including a Japanese subpopulation. The safety profile was consistent with previous studies and ophthalmologic parameters generally agreed with baseline values (EUDRACT 2006-003337-32).

Iron, copper and zinc concentrations in human sweat and plasma; the effect of exercise

1988 ◽  
Vol 177 (1) ◽  
pp. 81-87 ◽  
Author(s):  
O.I. Aruoma ◽  
T. Reilly ◽  
D. MacLaren ◽  
B. Halliwell
Keyword(s):  
Human Sweat ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Zinc Concentrations
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