Concurrent lacrimal gland melanocytoma and ocular melanocytosis in a dog

Journal of Veterinary Diagnostic Investigation ◽

10.1177/10406387211045027 ◽

2021 ◽

pp. 104063872110450

Author(s):

Ikki Mitsui ◽

Seigi Nishimura

Keyword(s):

Intraocular Pressure ◽

Lacrimal Gland ◽

Ciliary Body ◽

Mammalian Species ◽

Final Diagnosis ◽

Mixed Breed ◽

Elevated Intraocular Pressure ◽

Mitotic Figures ◽

Rostral Portion ◽

Ocular Melanocytosis

A 9-y-5-mo-old, spayed female, mixed-breed dog with buphthalmia and elevated intraocular pressure in the left eye, consistent with glaucoma, was evaluated. Black-pigmented, slightly elevated tissue with irregular margins was noted on the dorsolateral aspect of the left globe. Ultrasonography detected a mass, later identified as lacrimal gland, adjacent to the globe and the thickened uvea. The surgically removed lacrimal gland was effaced by dense sheets of melanin-laden cells. Within the enucleated globe, numerous melanin-laden cells infiltrated and expanded the rostral two-thirds thickness of the cornea, the entire anterior uvea (iris and ciliary body), and a rostral portion of the choroid. Melanin-laden cells in the left lacrimal gland and globe showed no nuclear atypia or mitotic figures, and reacted to anti-S100 and anti–melan A antibodies by immunohistochemistry. Our final diagnosis was concurrent lacrimal gland melanocytoma and ocular melanocytosis. The trabecular meshwork of the eye was obliterated by melanin-laden cells, which was the likely cause of glaucoma in this patient. To our knowledge, melanocytoma affecting the lacrimal gland has not been reported previously in a non-human mammalian species. Veterinary clinicians are encouraged to include melanocytoma in the differential list when examining an enlarged lacrimal gland.

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Benign Pleomorphic Adenoma Arising from the Palpebral Lobe of the Lacrimal Gland Associated with Elevated Intraocular Pressure

Ophthalmologica ◽

10.1159/000027434 ◽

1999 ◽

Vol 213 (4) ◽

pp. 269-272 ◽

Cited By ~ 5

Author(s):

Tetsuya Yamada ◽

Tsuyoshi Kato ◽

Seiji Hayasaka ◽

Yoriko Hayasaka ◽

Chiharu Kadoi

Keyword(s):

Intraocular Pressure ◽

Pleomorphic Adenoma ◽

Lacrimal Gland ◽

Palpebral Lobe ◽

Elevated Intraocular Pressure

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Ciliary Body Melanocytoma with Anterior Segment Pigment Dispersion and Elevated Intraocular Pressure

Journal of Glaucoma ◽

10.1097/00061198-199904000-00008 ◽

1999 ◽

Vol 8 (2) ◽

pp. 129???133 ◽

Cited By ~ 15

Author(s):

Anjali M. Bhorade ◽

Deepak P. Edward ◽

Debra A. Goldstein

Keyword(s):

Intraocular Pressure ◽

Ciliary Body ◽

Anterior Segment ◽

Pigment Dispersion ◽

Elevated Intraocular Pressure

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Faculty Opinions recommendation of Risk of elevated intraocular pressure and glaucoma in patients with uveitis: results of the multicenter uveitis steroid treatment trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718001992.793479524 ◽

2013 ◽

Author(s):

Carlos Pavesio ◽

Claire Hooper

Keyword(s):

Intraocular Pressure ◽

Steroid Treatment ◽

Treatment Trial ◽

Elevated Intraocular Pressure

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Superficially Spreading Endocervical Adenocarcinoma in situ with Multifocal Microscopic Involvement of the Endometrial Surface: A Case Report with Emphasis on the Potential for Misdiagnosis Based on Endometrial Curettage Specimens

Case Reports in Oncology ◽

10.1159/000511568 ◽

2020 ◽

Vol 13 (3) ◽

pp. 1530-1536

Author(s):

Inwoo Hwang ◽

Jiyeon Lee ◽

Kyue-Hee Choi ◽

Jiheun Han ◽

Hyun-Soo Kim

Keyword(s):

Final Diagnosis ◽

Accurate Diagnosis ◽

Surface Epithelium ◽

Apoptotic Bodies ◽

Small Tumor ◽

Histological Features ◽

Endocervical Adenocarcinoma ◽

Tumor Tissues ◽

Mitotic Figures

Misdiagnosis of endocervical adenocarcinoma (EAC) as endometrial endometrioid carcinoma (EEC) is one of the major concerns when evaluating endometrial curettage specimens. It is difficult to differentiate EAC involving the endometrium from EEC, particularly when the specimens have only a few small tumor fragments. We report a case of endocervical adenocarcinoma <i>in situ</i> (AIS) with multifocal microscopic involvement of the endometrium. The endometrial curettage specimen obtained from an 82-year-old woman consisted of a large volume of blood and fibrin, with small endometrial tissue fragments showing microscopic foci of atypical glandular proliferation. Based on the presence of complex glands with stratified mucin-poor columnar epithelium and intermediate-grade nuclear atypia, a preoperative diagnosis of grade 1 EEC was made. However, the hysterectomy specimen revealed an endocervical AIS involving the endocervix and low uterine segment. Frequent mitotic figures and apoptotic bodies, characteristic of AIS, were present. The endometrium showed a few microscopic foci of atypical glandular proliferation involving the surface only. Their histological features were similar to those of the endocervical AIS. Immunohistochemically, the atypical glands exhibited block p16 positivity. The final diagnosis was a superficially spreading endocervical AIS with multifocal microscopic involvement of the endometrial surface epithelium. In summary, small tumor tissues in an endometrial curettage may lead to misdiagnosis of AIS or EAC as EEC, especially when the pathologists are unaware of the possibility of microscopic endometrial involvement of AIS or EAC. The origin of the tumor can be correctly determined based on a combination of histological features and immunostaining. Endocervical AIS involving the endometrium should be included in the differential diagnosis of neoplastic glandular lesions in endometrial curettage specimens. An accurate diagnosis in these cases is important because of its significant implications for clinical management.

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Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration

Scientific Reports ◽

10.1038/s41598-021-91832-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maiko Maruyama-Inoue ◽

Tatsuya Inoue ◽

Shaheeda Mohamed ◽

Yoko Kitajima ◽

Shoko Ikeda ◽

...

Keyword(s):

Risk Factors ◽

Intraocular Pressure ◽

Macular Degeneration ◽

Intravitreal Injection ◽

Odds Ratio ◽

Japanese Patients ◽

Age Related Macular Degeneration ◽

Age Related ◽

Elevated Intraocular Pressure ◽

History Of

AbstractThe purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP.

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Minimally Invasive Surgery for Intraocular Lens Removal and Intrascleral Intraocular Lens Fixation with Trabeculectomy in a Patient with Dislocated Intraocular Lens and Elevated Intraocular Pressure

Case Reports in Ophthalmology ◽

10.1159/000511593 ◽

2021 ◽

pp. 538-542

Author(s):

Yuko Mano ◽

Kei Mizobuchi ◽

Tomoyuki Watanabe ◽

Akira Watanabe ◽

Tadashi Nakano

Keyword(s):

Intraocular Pressure ◽

Intraocular Lens ◽

Combined Therapy ◽

Swept Source ◽

Needle Technique ◽

Elevated Intraocular Pressure ◽

Anterior Segments ◽

The Right ◽

End Stage

A 88-year-old female who was being treated for end-stage pseudoexfoliation syndrome was referred to our hospital for treatment of dislocated intraocular lens (IOL) and the elevated intraocular pressure (IOP) and in the right eye (RE). At the first visit to our hospital, best-corrected visual acuity (BCVA) was 0.2 in the RE and 0.02 in the left eye (LE). IOP was 47 mm Hg in the RE and 21 mm Hg in the LE. Slit-lamp examination showed no abnormalities in anterior segments and dislocated IOL in the RE. Fundus photograph showed optic disc pallor in both eyes. We performed the combined therapy of flanged intrascleral IOL fixation with the double-needle technique and trabeculectomy. Throughout the follow-up period, BCVA slightly improved from 0.2 to 0.4 in the RE. The angle of tilt of the IOL was 6.6, 7.9, and 8.7° as measured by swept-source optical coherence tomography at 1, 4, and 6 months after the surgery, respectively. The IOP remained less than 10 mm Hg without having to administer any other glaucoma medications. Furthermore, any complications associated with the surgery were not confirmed.

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