Health-Related Quality of Life in the Spironolactone to Reduce ICD Therapy (SPIRIT) Trial

To describe health related quality of life (HRQOL) and symptoms in the SPIRIT trial and determine effects of implantable cardioverter defibrillator (ICD) shocks on HRQOL over 24 months. Ninety participants aged 66 ± 10 years, 96% men, 75% with NYHA class II, with an ICD were randomized to spironolactone 25 mg ( N = 44) or placebo ( N = 46). HRQOL was measured every 6 months for 24 months using: Patient Concerns Assessment (PCA), Short Form Health Survey-Veterans Version (SF-36V), and Kansas City Cardiomyopathy Questionnaire (KCCQ). Linear mixed modeling compared changes in HRQOL over-time and ANCOVA compared HRQOL between those getting an ICD shock or not. Over 24-months, there were no differences in HRQOL between the spironolactone versus placebo groups. Those with at least one ICD shock reported significantly lower HRQOL and more symptoms at 6- and 24-months. Patients receiving one or more ICD shocks reported significant reductions in HRQOL and higher symptoms.

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Health-Related Quality of Life in the Spironolactone to Reduce ICD Therapy (SPIRIT) Trial

10.1101/2020.08.27.20016378 ◽

2020 ◽

Author(s):

Ana Carolina Sauer Liberato ◽

Merritt H Raitt ◽

Ignatius GE Zarraga ◽

Karen S MacMurdy ◽

Cynthia Dougherty

Keyword(s):

Quality Of Life ◽

Kansas City ◽

Short Form ◽

Nyha Class ◽

Health Related Quality ◽

Icd Therapy ◽

Related Quality ◽

Health Related ◽

Icd Shock

Purpose: The Spironolactone to Reduce ICD Therapy (SPIRIT) trial was designed to determine whether once daily spironolactone would: 1) reduce the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF), and 2) improve health related quality of life (HRQOL) and symptoms. The purpose of this paper is to describe the long term HRQOL outcomes in the SPIRIT trial and compare QOL in those who did or did not receive implantable cardioverter defibrillator (ICD) shocks during follow-up. Methods: Ninety participants age 66+10 years, 96% men, 75% with NYHA class II, with an ICD at moderately high risk for recurrent VT/VF were randomized to spironolactone 25mg (N=44) or placebo (N=46). HRQOL was measured every 6 months for 24 months using 3 instruments: Patient Concerns Assessment (PCA), Short Form Health Survey-Veterans Version (SF-36V), and the Kansas City Cardiomyopathy Questionnaire (KCCQ). Linear mixed modeling was used to compare changes in HRQOL across 24-months. ANCOVA was used to compare HRQOL between those getting an ICD shock or not. Results: Over 24-months, there were no differences in HRQOL between the spironolactone vs. placebo groups. Those who experienced at least 1 ICD shock vs. those with no ICD shocks, reported significantly lower HRQOL and more symptoms at 6-months and 24 months. Conclusions: Spironolactone had no significant impact on HRQOL. Patients receiving one or more ICD shocks reported significant reductions in HRQOL and higher symptoms.

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Association of Physical Morbidity and Health-Related Quality of Life in a Representative Sample of Older German People

European Journal of Health Psychology ◽

10.1027/2512-8442/a000019 ◽

2018 ◽

Vol 25 (4) ◽

pp. 140-151

Author(s):

Markus A. Wirtz ◽

Matthias Morfeld ◽

Elmar Brähler ◽

Andreas Hinz ◽

Heide Glaesmer

Keyword(s):

Quality Of Life ◽

Representative Sample ◽

Short Form ◽

Physical Symptoms ◽

German Population ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related

Abstract. The association between health-related quality of life (HRQoL; Short-Form Health Survey-12; SF-12) and patient-reported morbidity-related symptoms measured by the Patient Health Questionnaire-15 (PHQ-15) is analyzed in a representative sample of older people in the general German population. Data from 1,659 people aged 60 to 85 years were obtained. Latent class analysis identified six classes of patients, which optimally categorize clusters of physical symptoms the participants reported: musculoskeletal impairments (39.8%), healthy (25.7%), musculoskeletal and respiratory/cardiac impairments (12.8%), musculoskeletal and respiratory impairments, along with bowel and digestion problems (12.9%), general impairments (4.9%), and general impairments with no bowel and digestion problems (4.8%). The participants’ SF-12 Physical Health Scores (η2 = .39) and their Mental Health Scores (η2 = .28) are highly associated with these latent classes. These associations remain virtually identical after controlling for age. The results provide evidence that profiles of patient-reported physical impairments correspond strongly with reduced HRQoL independently from aging processes.

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Health-Related Quality of Life in Children with Developmental Disorders

Current Developmental Disorders Reports ◽

10.1007/s40474-021-00235-z ◽

2021 ◽

Author(s):

Marina M. Schoemaker ◽

Suzanne Houwen

Keyword(s):

Quality Of Life ◽

Developmental Disorders ◽

Developmental Coordination Disorder ◽

Autism Spectrum ◽

Future Research ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Lower Hrqol

Abstract Purpose of Review (1) To give an overview of what is currently known about health-related quality of life (HRQoL) in three common and co-occurring developmental disorders: attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and developmental coordination disorder (DCD), and (2) to provide directions for future research. Recent Findings HRQoL is compromised in all three developmental disorders, affecting various domains of HRQoL. However, some domains are more affected than others depending on the nature of the core deficits of the disorder. Overall, parents’ rate HRQoL of their children lower than the children themselves. Children with ASD and ADHD with co-occurring disorders have lower HRQoL compared to those with singular disorders. Future studies in DCD are needed to investigate the effect of co-occurring disorder in this population. Summary Children with developmental disorders have lower HRQoL than typically developing children. Future research should focus on the effects of co-occurring disorders on HRQoL and on protective factors that may increase HRQoL. HRQoL should be a part of clinical assessment, as it reveals the areas in life children are struggling with that could be targeted during intervention.

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Factors Affecting Health-Related Quality of Life After the Arterial Switch Operation

World Journal for Pediatric and Congenital Heart Surgery ◽

10.1177/2150135121990651 ◽

2021 ◽

Vol 12 (3) ◽

pp. 344-351

Author(s):

Julie Cleuziou ◽

Anna-Katharina Huber ◽

Martina Strbad ◽

Masamichi Ono ◽

Alfred Hager ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Arterial Switch Operation ◽

Health Related Quality ◽

Switch Operation ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

Cardiac Medication

Background: Long-term morbidity and mortality outcomes of the arterial switch operation (ASO) in patients with transposition of the great arteries and Taussig-Bing anomaly are excellent. With an increasing number of patients reaching adolescence and adulthood, more attention is directed toward quality of life. Our study aimed to determine the health-related quality of life (hrQoL) outcomes in patients after the ASO and identify factors influencing their hrQoL. Methods: In this cross-sectional study, hrQoL of patients after ASO was assessed with the German version of the Short Form-36 (SF-36) and the potential association of specified clinical factors was analyzed. Patients of at least 14 years of age who underwent ASO in our institution from 1983 were considered eligible. Results: Of the 355 questionnaires sent to eligible patients, 261 (73%) were available for analysis. Compared to the reference population, patients who had undergone ASO had a significantly higher score in all subscales of the SF-36 except for vitality ( P < .01). Patients with an implanted pacemaker ( P = .002), patients who required at least one reoperation ( P < .001), and patients currently taking cardiac medication ( P < .004) or oral anticoagulation ( P = .036) had lower physical component scores compared to patients without these factors. Conclusions: Patients’ self-assessed and self-reported hrQoL after ASO (using German version of the Short Form 36) is very good. In this population, hrQoL is influenced by reoperation, the need for a pacemaker, and current cardiac medication or anticoagulant use. The development of strategies designed to mitigate or minimize the requirements for, and/or impact of these factors may lead to better hrQoL in this patient population.

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Health-related quality of life prospectively evaluated by the 8-item short form after endovascular repair versus open surgery for abdominal aortic aneurysms

Heart and Vessels ◽

10.1007/s00380-017-0956-9 ◽

2017 ◽

Vol 32 (8) ◽

pp. 960-968 ◽

Cited By ~ 2

Author(s):

Takayoshi Kato ◽

Mototsugu Tamaki ◽

Tomohiro Tsunekawa ◽

Yusuke Motoji ◽

Akihiro Hirakawa ◽

...

Keyword(s):

Quality Of Life ◽

Open Surgery ◽

Short Form ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Health Related Quality ◽

Abdominal Aortic ◽

Related Quality ◽

Health Related

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Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing–remitting multiple sclerosis: findings from the CONFIRM study

Multiple Sclerosis Journal ◽

10.1177/1352458513507818 ◽

2013 ◽

Vol 20 (2) ◽

pp. 253-257 ◽

Cited By ~ 26

Author(s):

Mariko Kita ◽

Robert J Fox ◽

J Theodore Phillips ◽

Michael Hutchinson ◽

Eva Havrdova ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Short Form ◽

Dimethyl Fumarate ◽

Phase Iii ◽

Health Related Quality ◽

Relapsing Remitting ◽

Related Quality ◽

Health Related

Multiple sclerosis (MS) has a significant impact on health-related quality of life (HRQoL) with symptoms adversely affecting many aspects of everyday living. BG-12 (dimethyl fumarate) demonstrated significant efficacy in the phase III studies DEFINE and CONFIRM in patients with relapsing–remitting MS. In CONFIRM, HRQoL was worse in patients with greater disability at baseline, and who relapsed during the study, and improved with BG-12 treatment. Mean Short Form-36 Physical Component Summary scores for BG-12 increased over 2 years and scores for placebo decreased. Coupled with clinical and neuroradiological benefits, these HRQoL results further support BG-12 as an effective oral treatment for relapsing MS.

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Improving the measurement of health-related quality of life in adolescent with idiopathic scoliosis: The SRS-7, a Rasch-developed short form of the SRS-22 questionnaire

Research in Developmental Disabilities ◽

10.1016/j.ridd.2014.01.020 ◽

2014 ◽

Vol 35 (4) ◽

pp. 784-799 ◽

Cited By ~ 25

Author(s):

Antonio Caronni ◽

Fabio Zaina ◽

Stefano Negrini

Keyword(s):

Quality Of Life ◽

Idiopathic Scoliosis ◽

Short Form ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Individual social capital and health-related quality of life among older rural Chinese

Ageing and Society ◽

10.1017/s0144686x15001099 ◽

2015 ◽

Vol 37 (2) ◽

pp. 221-242 ◽

Cited By ~ 3

Author(s):

XIAOJIE SUN ◽

KUN LIU ◽

MARTIN WEBBER ◽

LIZHENG SHI

Keyword(s):

Quality Of Life ◽

Social Capital ◽

Short Form ◽

Health Related Quality ◽

Chinese People ◽

Individual Social Capital ◽

Related Quality ◽

Health Related ◽

Resource Generator

ABSTRACTNo study based on the Resource Generator has explored the association between individual social capital and health-related quality of life among older adults. This study aims to evaluate the validity and reliability of the adapted Resource Generator-China, and examine the association between individual social capital measured by the Resource Generator-China and health-related quality of life of older rural-dwelling Chinese people. A field survey including 975 rural-dwelling people aged between 60 and 75 years was conducted in three counties of the Shandong Province of China in 2013. Quality of life was measured by the Chinese version of the 36-Item Short Form Health Survey (SF-36): scores of Physical Component Summary and Mental Component Summary. Cumulative scale analyses were performed to analyse the homogeneity and reliability of the Resource Generator-China. We constructed generalised linear models by gender to examine the associations of social capital with health-related quality of life. Our findings suggest that the adapted instrument for older rural-dwelling Chinese people can be a reliable and valid measure of access to individual social capital. There were positive associations between individual social capital (total scores and sub-scale scores) and health-related quality of life. Individual social capital had a stronger association with mental health among women than men. Future studies should be improved through a longitudinal design with a larger and randomised sample covering large geographical rural areas in China.

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ASSESSMENT OF THE HEALTH-RELATED QUALITY OF LIFE IN OUTPATIENTS WITH DIABETES MELLITUS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2020.6.5 ◽

2019 ◽

pp. 35-42

Author(s):

Tri Vo Duc ◽

Ngoc Nguyen Phuoc Bich

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Health Related Quality ◽

Vas Score ◽

Related Quality ◽

Health Related ◽

The Mean ◽

Lower Hrqol ◽

Eq Vas

Background: The prevalence of diabetes mellitus (DM) has been increasing significantly in the world as well as in Viet Nam. DM is a serious and complex chronic disease that affects the physical health of the patients and lower health-related quality of life (HRQoL). Objectives: (1) To analyze the HRQoL in DM outpatients at Hue University of Medicine and Pharmacy Hospital. (2) To evaluate the associated factorsin outpatients with DM. Materials and method: A cross-sectional descriptive study was conducted on 253 outpatients at Hue University of Medicine and Pharmacy Hospital. EuroQoL-5 dimension-5 level (EQ-5D-5L) scale was used for the assessment of HRQoL. Results: The median of the EQ-5D index was 0.85(interquartile range (IQR) = 0.28). The mean of EQ-VAS score was 64.07 (SD=16.99). Aging was associated with lower HRQoL. Unemployed participants had the lowest HRQoL index compared to workers. Higher educational levels led to higher HRQoL. Patients withDM duration of over 10 years had lower HRQoL index than the other groups. Conclusion: The median of the EQ-5D index was 0.85 (IQR = 0.28). The mean of EQ-VAS score was 64.07 (SD=16.99). The HRQoL in diabetic patients was associated with age, occupation, level of education and DM duration. Key words: EQ-5D-5L, quality of life, diabetes mellitus.

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