scholarly journals Association of Serum Galectin-3-Binding Protein and Metabolic Syndrome in a Chinese Adult Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Shihan Zhen ◽  
Ruoxin Cai ◽  
Xuelian Yang ◽  
Yanan Ma ◽  
Deliang Wen
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Adipose Tissue ◽  
Binding Protein ◽  
Adult Population ◽  
Biological Marker ◽  
Immunofluorescent Staining ◽  
Enzyme Linked Immunosorbent Assay ◽  
Regression Analyses ◽  
Galectin 3

BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.

scholarly journals Prevalence and risk factors of cytomegalovirus infection among HIV-infected and HIV-exposed uninfected infants in Nigeria

2015 ◽  
Vol 9 (09) ◽  
pp. 977-987 ◽  
Author(s):  
Emmanuel Ademola Anigilaje ◽  
Joseph Othniel Dabit ◽  
Nnamdi Okechukwu Nweke ◽  
Augustine Aondohemba Agbedeh
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oropharyngeal Candidiasis ◽  
Regression Analyses ◽  
Cmv Infection ◽  
Young Infants ◽  
Hiv Exposed ◽  
Exposed Uninfected

Introduction: Cytomegalovirus (CMV) co-infection increases morbidity and mortality in human immunodeficiency virus (HIV) disease. There has been no study on CMV infection and its risk factors among Nigerian HIV-infected and/or HIV-exposed uninfected infants. Methodology: This was a cross-sectional cohort study at the Federal Medical Center, Makurdi, between January 2012 and March 2013. Acute CMV infection among consecutive three-month- old HIV-infected and HIV-exposed uninfected infants was determined using the enzyme-linked immunosorbent assay of the CMV immunoglobulin M (IgM). The relationship between acute CMV infections in the infants and the potential risk factors was tested using logistic regression analyses. Results: The prevalence of acute CMV infection was 41.4% (91/220), including 12.1% (11/91) and 87.9% (80/91) among the HIV-infected and the HIV-exposed uninfected infants, respectively. In multivariate logistic regression analyses, oropharyngeal candidiasis in the infants, HIV co-infection in the infants, maternal mastitis during breastfeeding, and the absence of maternal chronic CMV infections significantly increased the risk of acute CMV in the young infants. Conclusions: In our setting, concerted efforts to prevent and/or promptly treat oropharyngeal candidiasis and mastitis during breastfeeding may reduce the burden of CMV among HIV-infected and HIV-exposed uninfected infants. Public enlightenment on the mode of CMV transmission and its prevention is also important.

Breakfast consumption is inversely associated with metabolic syndrome in a sample of Iranian adults

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Breakfast Consumption

Abstract Background: Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and metabolic syndrome of adult population living in Yazd Greater Area, Iran. Methods: This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n= 2896) were analyzed using multiple logistic regression method. Results: Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of metabolic syndrome after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR)= 0.38, 95% confidence interval (CI)= 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69 % lower in breakfast consumers in contrast to non-consumers (OR=0.31, 95% CI= 0.11, 0.87). However, no significant relationship was observed between other dietary habits and MetS after adjustment for all potential confounders Conclusions: This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and metabolic syndrome, more researches especially population-based cohort studies are needed to be conducted.

scholarly journals Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

2019 ◽  
Vol 20 (23) ◽  
pp. 5981 ◽  
Author(s):  
Federico Carbone ◽  
Maria Stefania Lattanzio ◽  
Silvia Minetti ◽  
Anna Maria Ansaldo ◽  
Daniele Ferrara ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Epicardial Fat ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Ectopic Fat ◽  
Men And Women ◽  
Fat Depots ◽  
Hs Crp

Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender in the crosstalk between visceral and epicardial fat depots and the role of adipocytokines and high-sensitivity C-reactive protein (hs-CRP). A total of 141 outward patients (both men and women) with one or more defining criteria for metabolic syndrome (MetS) were consecutively enrolled. For all patients, demographic and clinical data were collected and ultrasound assessment of visceral adipose tissue (VFth) and epicardial fat (EFth) thickness was performed. Hs-CRP and adipocytokine levels were assessed by enzyme-linked immunosorbent assay (ELISA). Men were characterized by increased VFth and EFth (p-value < 0.001 and 0.014, respectively), whereas women showed higher levels of adiponectin and leptin (p-value < 0.001 for both). However, only in women VFth and EFth significantly correlated between them (p = 0.013) and also with leptin (p < 0.001 for both) and hs-CRP (p = 0.005 and p = 0.028, respectively). Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (p = 0.012 and 0.007, respectively). In conclusion, men and women present differences in epicardial fat deposition and systemic inflammation. An intriguing association between visceral/epicardial fat depots and chronic low-grade inflammation also emerged. In women Although a further validation in larger studies is needed, these findings suggest a critical role of sex in stratification of obese/dysmetabolic patients.

scholarly journals Dietary Habits and its Association with Metabolic Syndrome in a large sample of Iranian adults: a population-based study

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Inverse Effect

Abstract Background Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of adult population living in Yazd Greater Area, Iran.Methods This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n = 2896) were analyzed using multiple logistic regression method.Results The prevalence of the MetS among the participants was 32.2%. Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to non-consumers (OR = 0.31, 95% CI = 0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confoundersConclusions This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

scholarly journals Dietary Habits and its Association with Metabolic Syndrome in a large sample of Iranian adults: a population-based study

2020 ◽  
Author(s):  
Elnaz Lorzadeh ◽  
Zohreh Sadat Sangsefidi ◽  
Masoud Mirzaei ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Dietary Habits ◽  
Adult Population ◽  
Middle Eastern ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cross Sectional ◽  
Logistic Regression Method

Abstract Background Central obesity, insulin resistance, dyslipidemia and hypertension are the core components of metabolic syndrome (MetS) which is coincident with unhealthy dietary habits in the Middle-Eastern countries. The aim of this study was to explore the association between dietary habits and MetS of adult population living in Yazd Greater Area, Iran. Methods This is a cross-sectional study which uses the data of a population-based cohort study on Iranian adults, known as Yazd Health Study (YaHS). The relationship between dietary habits and metabolic syndrome among adults (n = 2896) were analyzed using multiple logistic regression method. Results The prevalence of the MetS among the participants was 32.2%. Outcomes from logistic regression examining show that breakfast consumption has a significant inverse effect on the occurrence of MetS after adjustment for age, education level, physical activity statue, history of chronic diseases and smoking (odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.14, 0.97). This effect remains significant even after adjustment for body mass index (BMI) and reveals that odds of having MetS is 69% lower in breakfast consumers in contrast to non-consumers (OR = 0.31, 95% CI = 0.11, 0.87). However, no significant relationship was observed between other dietary habits including consumption of sweetened drinks, sugar cubes, and fast foods and MetS after adjustment for all potential confounders Conclusions This study revealed that eating breakfast has an inverse relationship with metabolic syndrome. Finding out stronger evidence in relation between dietary habits and MetS, more researches especially population-based cohort studies are needed to be conducted.

Association of Monocytes to High-Density Lipoprotein Cholesterol Ratio With Metabolic Syndrome and Its Components

2021 ◽  
Vol 34 (8) ◽  
pp. 888-889
Author(s):  
Ting-jun Wang ◽  
Xiao-qi Cai ◽  
Jin Gong ◽  
Qun-fang Xie ◽  
Guo-yan Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Logistic Regression ◽  
High Density Lipoprotein ◽  
Receiver Operating Characteristic ◽  
High Density Lipoprotein Cholesterol ◽  
Operating Characteristic ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Regression Analyses ◽  
Cholesterol Ratio

Abstract Background To investigate the association of monocytes to high-density lipoprotein cholesterol ratio (MHR) with metabolic syndrome (MS) and its components. Methods A cross-sectional clinical study was conducted from February 2018 to January 2019 in the First Affiliated Hospital of Fujian Medical University. A total of 890 inpatients or outpatients aged 30–79 years old were enrolled, and their clinical data were collected. MS and its components were defined according to the National Cholesterol Education Program Adult Treatment Panel III (NECP-ATPIII) diagnostic criteria. Spearman correlation and logistic regression analyses were used to analyze the association of MHR with MS and its components. A receiver operating characteristic analysis was used to evaluate the diagnostic efficacy of MHR for MS. Results The monocyte counts and MHR were significantly higher in subjects with MS than those without MS (P &lt; 0.001). The percentage of subjects carrying 3 or more MS components increased with the increment of MHR tertiles (13.7%, 32.7%, and 44.6%, P &lt; 0.001). MHR was correlated with multiple metabolic components, including body mass index, waist circumstance, visceral fat content, total cholesterol, triglyceride, fasting plasma glucose, glycosylated hemoglobin, and systolic blood pressure (all P &lt; 0.001). Logistic regression analyses showed that MHR was independently associated with MS after adjusting for age, gender, multiple metabolic components, and the use of antihypertensive and antihyperglycemic medications. Compared with the lowest tertile of MHR, the risk of MS increased by 2.386 and 3.233 times in moderate (P = 0.010) and highest (P = 0.001) tertiles, respectively. Receiver operating characteristic curve analyses indicated that the best cutoff value of MHR was 6.59 × 105/mg for the diagnosis of MS, with a sensitivity of 75.2% and a specificity of 52.7%. Conclusions Elevated MHR is associated with an increased risk of MS and the accumulation of its components.

Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome

2008 ◽  
Vol 17 (6) ◽  
pp. 392-398 ◽  
Author(s):  
Burcak Vural ◽  
Fatmahan Atalar ◽  
Cavlan Ciftci ◽  
Ayse Demirkan ◽  
Belgin Susleyici-Duman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Epicardial Adipose Tissue ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis

2019 ◽  
Vol 312 (6) ◽  
pp. 453-458
Author(s):  
Anna Stochmal ◽  
Joanna Czuwara ◽  
Michał Zaremba ◽  
Lidia Rudnicka
Keyword(s):  
Adipose Tissue ◽  
Systemic Sclerosis ◽  
Serum Level ◽  
Elevated Serum ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Vascular Abnormalities ◽  
Endothelin 1 ◽  
Fibrotic Process ◽  
Galectin 3

Abstract Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by progressive fibrosis, vascular impairment and immune abnormalities. In recent years, adipokines (mediators synthetized by adipose tissue) have been indicated as a possible missing link in the pathogenesis of SSc. The aim of this study was to investigate the serum concentration of metabolic adipose tissue factors: adiponectin, resistin, leptin and endothelial proteins: endothelin-1, fractalkine and galectin-3 in patients with systemic sclerosis. The study included 100 patients with confirmed SSc diagnosis and 20 healthy individuals. The concentration of respective proteins was determined by enzyme-linked immunosorbent assay. The following markers showed statistically significant increased mean concentrations in patients with SSc in comparison to healthy control: resistin (13.41 vs 8.54 ng/mL; P = 0.0012), endothelin-1 (1.99 vs 1.31 pg/mL; P = 0.0072) and fractalkine (2.93 vs 1.68 ng/mL; P = 0.0007). Elevated serum levels of galectin-3 (4.54 vs 3.26 ng/mL; P = 0.0672) and leptin (19,542 vs 14,210 pg/mL; P = 0.1817) were observed. Decreased concentration of adiponectin was found in patients with SSc (5150 vs 8847 pg/mL; P = 0.0001). Fractalkine and galectin-3 levels were significantly higher in diffuse cutaneous SSc than limited cutaneous SSc subset (3.93 ng/mL vs 2.58 ng/mL, P = 0.0018; 6.86 ng/mL vs 3.78 ng/mL, P = 0.0008, respectively) and correlated positively with modified Rodnan Skin Score in total SSc patients (r = 0.376, P = 0.0009; r = 0.236, P = 0.018, respectively). In conclusion, an increased serum level of resistin associated with increased endothelin-1 and fractalkine level and decreased adiponectin level may indicate a significant role of the adipose tissue in the development and progression of vascular abnormalities in patients with systemic sclerosis. Fractalkine and galectin-3 may participate in promoting and exacerbating the fibrotic process in SSc.

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